Severe sepsis and septic shock: review of the literature and emergency department management guidelines.

Abstract:

:Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation.

journal_name

Ann Emerg Med

authors

Nguyen HB,Rivers EP,Abrahamian FM,Moran GJ,Abraham E,Trzeciak S,Huang DT,Osborn T,Stevens D,Talan DA,Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group.

doi

10.1016/j.annemergmed.2006.02.015

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

28-54

issue

1

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(06)00248-4

journal_volume

48

pub_type

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