Abstract:
BACKGROUND AND PURPOSE:Ablation by cold (cryoablation) or radiofrequency energy (RFA), has been popularized for the treatment of small renal tumors. Regrettably, there currently is no reliable method of radiologically monitoring the propagation of RF lesions in real time. Ultrasonography enhanced by gas-filled microbubble contrast agents allows depiction of regions of tissue perfusion and has been described as a useful adjunct in diagnosing renal pseudotumors, improving prostate biopsy results, and confirming successful ablation of liver tumors. We hypothesized that contrast-enhanced ultrasonography (CEUS) would allow us to define, in real time, areas of cell death secondary to RFA and thus determine successful treatment. MATERIALS AND METHODS:Five female swine underwent initial laparoscopic exploration and creation of ipsilateral upper- and lower-pole renal RFA lesions. Lesion size was measured with standard gray-scale, Doppler, and microbubble CEUS. After 2 weeks, an identical procedure was performed on the contralateral kidney, including repeat sonographic measurements on the first kidney. All swine were then immediately sacrificed, and both kidneys (20 lesions) were harvested for pathologic analysis (hematoxylin-eosin and nicotinamide adenine dinucleotide stains). Radiographic lesion size was then compared with the gross and microscopic findings. RESULTS:The RFA lesions could not be imaged accurately in real time with standard gray-scale or Doppler sonography. However, microbubble CEUS was able to monitor parenchymal blood flow and, thus, the lesions (no blood flow) in real time. Hypoechoic lesions (no bubble enhancement) imaged during contrast sonography corresponded with regions of cell death as demonstrated on pathologic analysis. CONCLUSIONS:Microbubble CEUS is can monitor RFA lesions in real time. This novel imaging modality should allow more effective renal tumor ablation.
journal_name
J Endouroljournal_title
Journal of endourologyauthors
Slabaugh TK,Machaidze Z,Hennigar R,Ogan Kdoi
10.1089/end.2005.19.579subject
Has Abstractpub_date
2005-06-01 00:00:00pages
579-83issue
5eissn
0892-7790issn
1557-900Xjournal_volume
19pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Magnesium (Mg(2+)) has been shown to be a kidney stone inhibitor; however, the exact mechanism of its effect is unknown. Using theoretical models, the interactions of calcium and oxalate were examined in the presence of Mg(2+). METHODS:Molecular dynamics simulations were performed with NAMD and ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2013.0173
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Among patients with renal insufficiency secondary to autosomal dominant polycystic kidney disease (ADPKD), the onset of refractory urinary infection, hypertension, pain, or hematuria often necessitates a nephrectomy. However, the huge size of these kidneys makes a standard laparoscopic approach difficult, an...
journal_title:Journal of endourology
pub_type: 杂志文章,评审
doi:10.1089/089277904323056942
更新日期:2004-05-01 00:00:00
abstract::Looking for a virtually "scarless" surgery mini-laparoscopy (ML) could be a viable alternative to conventional laparoscopy. ML is a reproducible technique and allows for the preservation of the triangulation concept, the cornerstone of laparoscopic surgery. Drawback of ML could be the poor performance of miniaturized ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2015.0782
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The centrality-index (C-Index), preoperative aspects and dimensions used for anatomic (P.A.D.U.A.) classification, and radius.exophyic/endophytic.nearness.anterior/posterior.location (R.E.N.A.L.) nephrometry schemes were developed as standardized scoring systems (SS) to quantify anatomic characte...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2011.0301
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The treatment of bilateral urinary calculus disease is often staged, irrespective of the modality of the treatment. Bilateral simultaneous percutaneous nephrolithotomy (PCNL) is still considered by many to be adventurous and risky. We carried out this prospective study of bilateral PCNL under a s...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1089/end.2000.14.285
更新日期:2000-04-01 00:00:00
abstract::The appeal of laser therapy is rooted in its absence of complications relative to the gold standard of transurethral electroresection. As in any evaluation of a new medical intervention, efficacy must be weighed against the degree of complications that accompany it. Although there has been a relative paucity of litera...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.1995.9.183
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:To define factors associated with the failure of shockwave lithotripsy (SWL) in the treatment of ureteral stones. PATIENTS AND METHODS:We retrospectively studied 405 men and 283 women (mean age 52.6 years) who underwent SWL with a second-generation lithotripter in the period 1994 to 2001. We evaluated availabl...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277903765444302
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To evaluate the physical properties of urethral catheters that are predictive of ease of placement and risk of urethral trauma: Stiffness, buckling, and friction forces. MATERIALS AND METHODS:Eleven Bard Lubri-Sil and 10 Kendall Dover 16F Foley catheters were tested using a linear motion stage driven by a step...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2008.0503
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess if the presence of a lower pole stone (LPS) decreases the stone-free (SF) rate following retrograde intrarenal surgery (RIRS). The second purpose was to assess the result of RIRS for LPS and to identify predictors of SF status. PATIENTS AND METHODS:We retrospectively analyzed 205 procedures in 162 ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2013.0515
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Robot-assisted partial nephrectomy has emerged as a viable surgical treatment for patients with certain renal tumors. We hypothesized that extirpation of more complex tumors, as graded with the nephrometry score, would result in worse operative and postoperative outcomes when compared with tumors...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2011.0003
更新日期:2011-10-01 00:00:00
abstract::A 55-year-old man had a solid tumor in the right part of a horseshoe kidney. He had previously undergone open cholecystectomy and appendectomy with panperitonitis. Retroperitoneoscopic nephrectomy was performed, with rapid recovery and good short-term results. This appears to be the first case of endoscopic surgery on...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277903772036253
更新日期:2003-12-01 00:00:00
abstract:: Purpose: Kidney stone recurrence rates vary between patients. A patient's risk informs the frequency and intensity of preventative interventions. Clinicians routinely use clinical experience to estimate risk. We sought to compare clinician estimated recurrence risk with th...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2020.0978
更新日期:2020-11-16 00:00:00
abstract:: Introduction: This exploratory retrospective analysis examined any potential prognostic role of preoperative neutrophil lymphocyte ratio (NLR) for progression-free survival (PFS) and time to endoscopically verified upper tract or bladder recurrence-free survival (RFS) in u...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2020.0283
更新日期:2020-09-01 00:00:00
abstract::Inability to remove a urethral catheter after radical retropubic prostatectomy is an uncommon complication. We describe removal of a urethral catheter entrapped in vesicourethral anastomotic sutures, which was safely performed endoscopically using a holmium laser. ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2005.19.83
更新日期:2005-01-01 00:00:00
abstract::Ureteral stents find wide application in urology. The majority of patients with indwelling ureteral stents are at an increased risk of urinary tract infection. Stent encrustation and its associated complications lead to significant morbidity. This review critically evaluates various polymers that find their applicatio...
journal_title:Journal of endourology
pub_type: 历史文章,杂志文章,评审
doi:10.1089/end.2009.0516
更新日期:2010-02-01 00:00:00
abstract::Patients with large median prostate lobes undergoing robot-assisted radical prostatectomy are at potential risk of ureteric orifice injury, during posterior bladder neck transection and vesicourethral anastomosis reconstruction. We describe our technique of in situ robot-assisted ureteral stenting with double-pigtail ...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章
doi:10.1089/end.2009.0133
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:We evaluated the feasibility and effectiveness of percutaneous urinary diversion in patients with obstructive uropathy. PATIENTS AND METHODS:A total of 206 percutaneous nephrostomies (PCNs) (right-sided in 54, left in 56, and bilateral in 48) were performed in 102 male and 57 female patients 18 to 94 years ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2000.14.401
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Holmium:yttrium-aluminum-garnet (Ho:YAG) laser lithotripsy is the standard lithotrite in ureteroscopy. We investigated the influence of pulse frequency, energy and length on the fragmentation efficiency of Ho:YAG laser lithotripsy in non-floating artificial stones in vitro. MATERIALS AND METHODS...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2010.0115
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To determine the effects of previous open nephrolithotomy on the results and morbidity of subsequent percutaneous nephrolithotomy (PCNL). PATIENTS AND METHODS:Between March 2005 and January 2006, 89 patients underwent PCNL at our institution. We compared the patients who had had previous open surgery on the sa...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.0293
更新日期:2007-04-01 00:00:00
abstract:INTRODUCTION:Recent evidence would suggest a low rate of metabolic assessment in stone formers, even in those deemed as high risk. We wished to assess the attitudes and practice patterns of metabolic work up in North American members of the Endourological Society as part of the management of stone-forming patients. ME...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2015.0207
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The treatment of cystine stones is a clinical problem. This in vitro study was performed to establish an experimental system that enables standardized and reproducible investigations on chemolysis of cystine stones to look for an improvement of dissolution strategies. MATERIALS AND METHODS:Artif...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2000.14.451
更新日期:2000-06-01 00:00:00
abstract:INTRODUCTION:The use of a ureteral access sheath (UAS) may provide significant advantages, particularly, in the treatment of a large renal stone burden. However, in some patients, the passage of a UAS up the ureter is impossible. We prospectively evaluated the ability to insert a 14F UAS and analyzed the possible predi...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2014.0215
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To assess the effectiveness of palladium-103 brachytherapy in stage T1 and T2 adenocarcinoma of the prostate. PATIENTS AND METHODS:The charts of 1048 patients treated between 1991 and 1999 with transperineal realtime ultrasound-guided (103)Pd (Theraseed) implants were reviewed to assess the effects on serum pr...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2000.14.343
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To provide a realistic experience of lower urinary tract endoscopic procedures, we have developed and continue to expand a computer-based surgical simulator that incorporates a surgical tool interface with anatomic detail and haptic feedback. METHODS:Surface-based geometric data for the lower ur...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/089277902753716179
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Clinically significant post-transplantation lymphoceles are not uncommon. Surgical marsupialization with internal peritoneal drainage is the treatment of choice. We describe the successful laparoscopic formation of a peritoneal window for post-transplantation lymphocele drainage as an effective a...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.20.904
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Performance of laparoscopic surgery requires adequate hand-eye coordination. Video games are an effective way to judge one's hand-eye coordination, and practicing these games may improve one's skills. Our goal was to see if there is a correlation between skill in video games and skill in laparosc...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1089/end.2005.19.372
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic unilateral hematuria is characterized by intermittent or continuous gross hematuria that cannot be diagnosed using standard radiology and hematology methods. In the past, it was managed with partial or total nephrectomy. In the age of minimally invasive procedures, however, endoscopy has ...
journal_title:Journal of endourology
pub_type: 临床试验,杂志文章
doi:10.1089/end.2009.0064
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To evaluate forces exerted on a stone with different ureteroscopic irrigation systems that could impact stone migration during ureteroscopy. MATERIALS AND METHODS:A 3-mm steel simulated stone was welded to a 3F stone basket. The basket wire was then backloaded into the working channel of a 4.5F Wolf semirigid ...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2007.0260
更新日期:2008-03-01 00:00:00
abstract::During cryotherapy of the prostate, identification of probe tips that are misplaced into the bladder is often not readily apparent via transrectal ultrasonography. Ultimately, cystoscopy is needed to ensure this has not occurred before initiating a freeze. We describe the innovative use of continuous flexible cystosco...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2011.0417
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Adequate urine production and excretion may be important for clearance of stone fragments after extracorporeal shockwave lithotripsy (SWL). This study evaluated the impact of renal function, measured by preoperative serum creatinine concentration, on the efficacy of SWL. PATIENTS AND METHODS:Fro...
journal_title:Journal of endourology
pub_type: 杂志文章
doi:10.1089/end.2006.0319
更新日期:2007-05-01 00:00:00