Abstract:
:ABO incompatibility is not considered a contraindication for allogeneic haematopoietic stem cell transplantation (HSCT) despite its association with several immunohaematological complications. At present, there is no general agreement concerning the best methods to reduce these problems. To survey current practice related to ABO-incompatible HSCT in Italy, a questionnaire was sent to all GITMO centres. Specific questions were addressed for management in pretransplant, peritransplant and post transplant phases. A comparison was made with the experience reported in the literature. In all, 74% of GITMO centres answered the questionnaire. A high degree of heterogeneity concerning the pretransplant tests, methods to overcome infusion of ABO-incompatible marrow and post transplant transfusion policy and monitoring was evident. For many of these aspects the literature does not contain unanimous guidelines. The considerable degree of heterogeneity that reflects, at least partially, the lack of consensus in the literature demonstrates that ABO incompatibility is still an open issue in the setting of HSCT and that further studies are needed for a more rationale approach and for the production of evidence-based guidelines.
journal_name
Bone Marrow Transplantjournal_title
Bone marrow transplantationauthors
Raimondi R,Soli M,Lamparelli T,Bacigalupo A,Arcese W,Belloni M,Rodeghiero F,Gruppo Italiano Trapianto di Midolla Osseo.doi
10.1038/sj.bmt.1704579subject
Has Abstractpub_date
2004-08-01 00:00:00pages
321-9issue
4eissn
0268-3369issn
1476-5365pii
1704579journal_volume
34pub_type
杂志文章,多中心研究abstract::In this study, outcomes for 575 adult ALL patients aged ≥45 years who underwent first allo-SCT in CR were analyzed according to the type of conditioning regimen (myeloablative conditioning (MAC) for 369 patients vs reduced-intensity conditioning (RIC) for 206 patients). Patients in the RIC group were older (median age...
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doi:10.1038/sj.bmt.1705311
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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pub_type: 杂志文章
doi:
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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