Abstract:
:9-Aminocamptothecin (9-AC) is a water-insoluble camptothecin derivative that demonstrated broad activity in pre-clinical studies. In vitro, greater anti-tumor efficacy can be achieved with prolonged administration. A minor response was observed in gastric cancer in a phase I study. We conducted a phase II study of 9-AC in 15 patients with previously untreated metastatic gastric cancer and adenocarcinoma of the gastroesophageal junction. 9-AC was administered at a dose of 25 microg/m(2)/h over 120 hours (3000 microg/m(2) over 5 days) on two consecutive weeks every 21 days. Fourteen patients were evaluable for response. There were no objective responses. Three patients had stable disease lasting a median of 3.4 months (range 1.6-4.3 months). Median time to progression was 1.4 months; median survival was 5.2 months. Grade 3 neutropenia developed in 20% of patients, and anemia in 7%. Grade 3 nausea and fatigue each developed in 7% of patients. We conclude that 9-AC given by 120-hour continuous infusion demonstrates no clinical activity in patients with metastatic gastric cancer.
journal_name
Invest New Drugsjournal_title
Investigational new drugsauthors
Kindler HL,Avadhani A,Wade-Oliver K,Karrison T,Mani S,Vokes EEdoi
10.1023/B:DRUG.0000026259.28395.c2subject
Has Abstractpub_date
2004-08-01 00:00:00pages
323-7issue
3eissn
0167-6997issn
1573-0646pii
5269629journal_volume
22pub_type
临床试验,杂志文章,多中心研究abstract:BACKGROUND:Lactoferrin is an iron-binding glycoprotein first identified in breast milk as a protein product of mammary epithelial cells. Its immunomodulatory functions include activation of NK and lymphokine-activated killer cells and enhancement of PMN and macrophage cytotoxicity. Studies in animal models have shown p...
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journal_title:Investigational new drugs
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journal_title:Investigational new drugs
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Investigational new drugs
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:Investigational new drugs
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Investigational new drugs
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-02-01 00:00:00
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journal_title:Investigational new drugs
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pub_type: 杂志文章
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journal_title:Investigational new drugs
pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Investigational new drugs
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00