Abstract:
:Recently, we published data of a 2 year randomized controlled study in which the effects of continuous versus symptomatic bronchodilator treatment in patients with moderate asthma or chronic bronchitis were investigated. The results showed that FEV1 decline in the continuously treated group was significantly larger than in the symptomatically treated group (72 versus 20 ml/year, P < 0.05). We reanalysed these data in order to investigate the hypothesis that the continuous use of bronchodilators may mask a rapid decline in lung function. Lung function decline was assessed by regression analysis of seven FEV1 measurements. Respiratory symptoms were assessed by means of the MRC questionnaire every 12 months, and they were also recorded by the patients in a weekly report. Of the participating patients 144 completed the study. Increased lung function decline in the continuously treated group was not reflected in a significant deterioration of the symptoms. Moreover, the decline in FEV1 showed no correlation at all with changes in respiratory symptoms in continuously treated patients (r = -0.03, P = 0.80), whereas in the symptomatically treated group, there was a better relation (r = -0.32, P = 0.003) to changes in respiratory symptoms. These results show that continuous bronchodilation may indeed mask the worsening of the disease. This lack of awareness of deterioration of the disease is probably caused by the continuous symptom relief of bronchodilators. It may be misleading to both patients and physicians.
journal_name
Fam Practjournal_title
Family practiceauthors
van Schayck CP,Folgering H,den Otter JJ,Tirimanna P,van Weel Cdoi
10.1093/fampra/9.4.397subject
Has Abstractpub_date
1992-12-01 00:00:00pages
397-404issue
4eissn
0263-2136issn
1460-2229journal_volume
9pub_type
临床试验,杂志文章,随机对照试验相关文献
FAMILY PRACTICE文献大全abstract:BACKGROUND:About 45.2 million people were displaced from their homes in 2012 due to persecution, political conflict, generalized violence and human rights violations. Refugees who endure violence are at increased risk of developing chronic psychiatric disorders such as posttraumatic stress disorder and major depression...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmu017
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Smokers vary in their readiness to try stopping smoking, but there currently are no objective tools for identifying smokers' consulting behaviours which indicate their level of motivation to try stopping smoking. OBJECTIVE:The aim of this study was to investigate the construct validity and inter-observer re...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/19.2.154
更新日期:2002-04-01 00:00:00
abstract::In November 1991 69% of a random sample of 998 Danish general practitioners (GPs) participated in a survey by anonymously filling in a mailed questionnaire concerning the way in which they use health education in their practices. Among the participating GPs, 97% used health education material. The study showed differe...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/11.1.35
更新日期:1994-03-01 00:00:00
abstract:Background:The reason why patients contact a care provider, the reason for encounter (RFE), reflects patients' personal needs and expectations regarding medical care. RFEs can be symptoms or complaints, but can also be requests for diagnostic or therapeutic interventions. Objectives:Over the past 30 years, we aim to a...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmy031
更新日期:2018-12-12 00:00:00
abstract:PURPOSE:Chilean patients with type 2 diabetes mellitus (T2DM) have a low rate of blood sugar control. We studied the effectiveness of a culturally sensitive family oriented intervention designed to improve metabolic control in primary care patients with uncontrolled T2DM. METHODS:Patients with T2DM from three primary ...
journal_title:Family practice
pub_type: 杂志文章,多中心研究
doi:10.1093/fampra/cmq069
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Little is known about the frequency with which information from the Internet is presented by patients within primary care consultations or the subsequent impact that it may have on those consultations. OBJECTIVES:The aims of this study were to describe the frequency with which Internet information was prese...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmh215
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Both treatment guidelines and the amount of antibiotics used for acute otitis media (AOM) vary across western countries. Parental expectations and their awareness of antimicrobial use and resistance, which may also be influenced by the guidelines, are not yet completely known. OBJECTIVE:To compare parental ...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmp055
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:To improve earlier presentation with potential symptoms of cancer, accurate data are needed on how people respond to these symptoms. It is currently unclear how self-reported medical help-seeking for symptoms associated with cancer by people from the community correspond to what is recorded in their general ...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmz047
更新日期:2020-02-19 00:00:00
abstract::With current moves towards an emphasis on the 'whole' patient rather than fragmenting the person into organ systems research methods need to be developed which reflect that emphasis and direct us in our endeavour as clinicians. It is possible to have a descriptive science of human behaviour which can be based upon cli...
journal_title:Family practice
pub_type: 临床试验,杂志文章,评审
doi:10.1093/fampra/4.4.311
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:The safety of non-steroids anti-inflammatory drugs (NSAIDs) in the context of pharyngitis is doubtful with contradictory results in the literature. OBJECTIVE:To evaluate the risk of peritonsillar abscess (PTA) associated to NSAIDs consumption during a pharyngitis episode observed in primary care. METHOD:A ...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmy111
更新日期:2019-07-31 00:00:00
abstract:BACKGROUND:Recent guidelines for treatment of hypertension advocate a multifactorial approach based on absolute risk of a cardiovascular event. However, this does not take any account of individual patient values or preferences for health outcomes that result from having hypertension. OBJECTIVE:Our aim was to investig...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/18.3.309
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:It is unclear whether discharging patients from renal clinic to primary care is safe. AIM:To determine the characteristics, primary care monitoring and renal outcomes of patients discharged from renal clinic. DESIGN AND SETTING:A retrospective study of 2236 adults discharged from a tertiary renal clinic be...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmz055
更新日期:2020-03-25 00:00:00
abstract:BACKGROUND:In 2010, a new telephone service, NHS 111, was piloted to improve access to urgent care in England. A unique feature is the use of non-clinical call takers who triage calls with computerized decision support and have access to clinical advisors when necessary. Aim. To explore users' acceptability of NHS 111....
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmt078
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Despite its public health significance, data about depression in general practice are often unavailable. OBJECTIVE:To study (i) the incidence of GP-diagnosed depression during 2008, (ii) associations between patient characteristics, appraised severity and initiated treatment, (iii) GPs' usual care compared ...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cms024
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to estimate the frequency of albuminuria in patients with and without diabetes mellitus, answering the question: 'How relevant for general practice are epidemiological findings that albuminuria is a significant risk indicator for the development of cardiovascular syndromes?'. METHO...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/16.6.580
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:A movement is emerging to encourage health providers and health organizations to take action on the social determinants of health. However, few evidence-based interventions exist. Digital tools have not been examined in depth. OBJECTIVE:To assess the acceptability and feasibility of integrating, within rout...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmy129
更新日期:2019-10-08 00:00:00
abstract::Before implementing a guideline, reassurance is needed that the guideline is valid, reproducible and reliable. A method for assessing guideline validity has now been developed for general use. Guideline producers need to consider suitable strategies for implementing their guidelines. When designing and evaluating a gu...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/17.suppl_1.s3
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Evaluation of health care contacts from first events alone often misses large amounts of potentially important data and may produce different results than evaluation of all data including recurrent events. OBJECTIVE:We aim to bring the different methodological approaches for analysing longitudinal health ca...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cml012
更新日期:2006-08-01 00:00:00
abstract::Cancer of the colon is the second most common malignancy in North America and screening methods are needed for diagnosing the lesions at an early stage. Faecal occult blood screening is a method of secondary prevention which is particularly adaptable to the family practice setting. In order to test the feasibility of ...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/3.4.246
更新日期:1986-12-01 00:00:00
abstract:Introduction:We must study alternatives to structure an effective diabetic retinopathy screening program for Brazilian public health system. Objectives:Evaluate the diagnostic performance of retinal digital photography for diabetic retinopathy screening in primary care, accuracy of the family physician in diabetic ret...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmx020
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Studies examining the impact nurse prescribing have largely focused on the efficacy of the service. It was suggested in pro-prescribing policy arguments that extending the nursing role to include prescribing would increase job satisfaction. This assertion has not been fully explored. OBJECTIVES:To investiga...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmr077
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Patient experience and satisfaction are important indicators of quality in health care. Little is known about where to prioritize efforts to improve patient satisfaction. OBJECTIVES:To investigate patient satisfaction with primary care, as part of the Quality and Costs of Primary Care in Europe study in Eng...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmw004
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:In the UK, the GP contract requires annual consultations and offers of home visits to the elderly. However, as many as 50% of elderly people refuse the offer of a health screen. OBJECTIVE:To describe the characteristics of elderly people who declined the offer of an annual home visit. METHOD:All elderly pe...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/13.1.22
更新日期:1996-02-01 00:00:00
abstract:Background:Singapore's health care system is strained by the health care needs of a rapidly aging population. The unprecedented collaboration between a public hospital and a private family practice to set up the Family Medicine Clinic (FMC) to co-manage patients with chronic disease is an example of efforts to shift ca...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmy007
更新日期:2018-09-18 00:00:00
abstract::Doctors in different countries completed a questionnaire relating to the importance they attributed to eight possible sources of information about a new drug, their estimation of patients' expectations of the doctor prescribing drugs under specific circumstances and their therapeutic response to common clinical genera...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/4.2.123
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Primary physicians care for most patients with irritable bowel syndrome (IBS), but data on their attitudes and knowledge about the disorder are limited to research in the UK. OBJECTIVE:The purpose of the present study was to assess US family practitioners' attitudes and knowledge about IBS and determine the...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmg608
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:In Brazil, there continues to be an excessive use of emergency services by patients with elective medical problems. Those patients who report having a primary care physician are less likely to utilize the emergency department for non-urgent consultations. OBJECTIVE:The objective of this study was to compare...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/19.2.207
更新日期:2002-04-01 00:00:00
abstract::To determine whether patients read and remembered health promotion messages displayed in waiting rooms, 600 patients in a UK general practice were given a self-complete questionnaire. Two notice-boards carried between 1 to 4 topics over four study periods. Three-hundred and twenty-seven (55%) of subjects responded. Tw...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/11.3.292
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:The North Trent scheme to address the problem of GPs whose performance gives cause for concern was implemented in 1997. This paper describes the structure and process of the scheme and evaluates the main outcomes. METHODS:We used non-participant observation and semi-structured interviews with representative...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/18.2.123
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Recent guidelines on obesity management promote integrated care. There is little knowledge about local opportunities and barriers, faced by health care professionals and patients, that affect implementation of an integrated national health care standard in a local setting. Our aim is to understand experience...
journal_title:Family practice
pub_type: 杂志文章
doi:10.1093/fampra/cmr072
更新日期:2012-04-01 00:00:00