Abstract:
:The regulation of cell growth is fundamental to the maintenance of health: disturbed regulation can result in neoplasia. Genes in normal cells (protooncogenes) code for proteins involved in the regulation of cell growth and differentiation; abnormalities in these genes (oncogenes) or their expression are often involved in the development of cancer. This paper summarises the essentials of the complex cell growth regulatory mechanisms, their genetic control, and their disturbances in neoplasia, emphasising the role of cancer-promoting (oncogenes) and suppressing genes (onco-suppressors or anti-oncogenes), especially in relation to oral carcinoma, and discusses the possible role of viruses as one cause of neoplasia.
journal_name
Br Dent Jjournal_title
British dental journalauthors
Scully Cdoi
10.1038/sj.bdj.4807936subject
Has Abstractpub_date
1992-07-25 00:00:00pages
53-9issue
2eissn
0007-0610issn
1476-5373pii
4807936journal_volume
173pub_type
杂志文章,评审abstract::Periodontal disease continues to be a major concern for dentists and patients. This paper reports the findings of the 1998 UK Adult Dental Health survey in relation to plaque, calculus, periodontal pocketing and loss of attachment. It is apparent from this study that moderate periodontal disease remains commonplace am...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4801135
更新日期:2001-08-25 00:00:00
abstract::The prevalence of overweight and obesity is rising in many developed and developing countries and, most worryingly, among children. Within the EU, Scotland has the highest prevalence, more than twice that of the Netherlands, and in England almost a quarter of children now enter primary school either overweight or obes...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2012.1009
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Malignant tumours of the nasal cavity and paranasal sinuses are rare and late presentation of a maxillary sinus tumour is common due to the vague nature of the symptoms which can delay diagnosis. METHODS:We report a female with a maxillary sinus tumour who was initially diagnosed with chronic idiopathic faci...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2012.468
更新日期:2012-06-08 00:00:00
abstract::A report is presented of a study which was carried out to investigate the standard of impressions for anterior crowns received at a commercial dental laboratory in Great Britain. Aspects examined were the type of tray and its suitability to the impression technique used, fixation of the impression to the tray, the met...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808129
更新日期:1993-04-10 00:00:00
abstract::It is now more than one year since the Specialist List in Orthodontics closed on 30 June 2000. I therefore felt it appropriate that I should give my views on the list, having probably had more experience in this process than any other dentist in the UK. ...
journal_title:British dental journal
pub_type: 社论
doi:10.1038/sj.bdj.4801168a
更新日期:2001-09-22 00:00:00
abstract::Objectives The objectives of the prospective study were to establish the prevalence of distal caries (DC) in the mandibular second molar and to assess the outcomes of these diseased teeth in our population. Further aims were to identify associated risk factors and to design a protocol for prevention.Methods Clinical a...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2016.677
更新日期:2016-09-23 00:00:00
abstract::It has been suggested that small doses of opioid drugs given prior to surgery can reduce postoperative pain. This study was designed to compare the effectiveness of a paracetamol/codeine combination and paracetamol alone in preventing the pain following surgical removal of impacted third molar teeth under general anae...
journal_title:British dental journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.bdj.4809081
更新日期:1996-05-11 00:00:00
abstract::In another article in this series the authors' preference for screw retained implant supported restorations was presented together with a literature review and rationale.(1) There remain situations when screw retention is not possible due to implant position, implant trajectory, aesthetics or function. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4814205
更新日期:2006-11-11 00:00:00
abstract::There are international grumbles from those perturbed by an impending identity crisis within oral and maxillofacial surgery (OMFS). This unrest is further compounded by scattered suggestions that a name change may prove beneficial in raising the profile of OMFS. The purpose of this paper is to consider novel methods o...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2010.1180
更新日期:2011-01-08 00:00:00
abstract::This clinical article describes and discusses a technique, using a preoperative occlusal matrix, whereby the occlusal morphology of a tooth may be replicated when placing a posterior resin composite. Two clinical cases are described. The technique offers the clinician considerable time saving for required occlusal adj...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2009.215
更新日期:2009-03-28 00:00:00
abstract::Introduction Invasive cervical resorption (ICR) has an unknown aetiology, yet it exhibits very aggressive behaviour compared with typical external root resorption, posing a high risk of tooth loss.Aim To investigate the number of patients at the Dublin Cleft Prosthodontic Department with an oro-facial cleft who experi...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2017.405
更新日期:2017-05-12 00:00:00
abstract::The effect of filtration on water fluoride level was investigated in a study using commercially available filters. Testing was carried out in London (low fluoride), Braintree (optimum fluoride, naturally occurring) and Birmingham (optimum fluoride, artificially adjusted). It was found that none of the filters removed ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809159
更新日期:1996-07-20 00:00:00
abstract::The British Orthodontic Society (BOS) recently published a number of news articles aimed at drawing attention to its 'Hold that Smile' campaign which promotes lifelong retainer wear. The BOS's stated intention is to 'generate a viral #HoldthatSmile campaign in order to build awareness of its message that retainers are...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2018.227
更新日期:2018-04-13 00:00:00
abstract::Aqueous sodium hypochlorite (bleach) solution is widely used in dental practice during root canal treatment. Although it is generally regarded as being very safe, potentially severe complications can occur when it comes into contact with soft tissue. This paper discusses the use of sodium hypochlorite in dental treatm...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/bdj.2007.374
更新日期:2007-05-12 00:00:00
abstract::A case is described of a patient who appeared to belong to the category labelled 'resistant' to local analgesia, in whom use of a 5% lignocaine solution with 1 in 100,000 adrenaline allowed painless routine dental treatment to be carried out. A discussion of the case, and the various other opinions which were consider...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4807371
更新日期:1990-11-24 00:00:00
abstract:INTRODUCTION:This paper reports participation of dentists in continuing professional development (CPD) and factors affecting participation. METHOD:All general dental practitioners (GDPs) in three deaneries in England were surveyed. The overall response rate was 54% (n = 2082); by deanery it was 68% West Midlands, 45% ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4802413
更新日期:2003-01-11 00:00:00
abstract::The International Caries Consensus Collaboration (ICCC) presented recommendations on terminology, on carious tissue removal and on managing cavitated carious lesions. It identified 'dental caries' as the name of the disease that dentists should manage, and the importance of controlling the activity of existing cavitat...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.672
更新日期:2017-08-11 00:00:00
abstract::The Shirley Glasstone Hughes Trust Fund was set up in 1990 in order to fund 'prizes or scholarships for dental research' and since 1991 it has provided grants for dental research projects. Between 2005 and 2006, the Trust reviewed the outcomes of its funding over the previous 15 years in order to assess the relevance ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2009.727
更新日期:2009-08-22 00:00:00
abstract:AIMS:The aims of this study were to articulate the concept of preparedness of dental graduates for foundation training programme in the United Kingdom and identify the essential attributes of preparedness. METHODS:A qualitative approach using semi-structured interviews was used to explore the concept of preparedness. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2014.648
更新日期:2014-08-01 00:00:00
abstract::An introduction to the practical application of acupuncture in dentistry is presented in the light of current research. It is concluded that acupuncture could supplement conventional treatment modalities. Its value in the treatment of temporomandibular dysfunction syndrome and facial pain has been well documented and ...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.4800704
更新日期:2000-08-12 00:00:00
abstract:OBJECTIVE:To report on the dental health of three-year-old children in Greater Glasgow, and to examine the amount of dental caries associated with deprivation in this young age group. DESIGN:Dental inspections in nursery schools. SUBJECTS AND METHODS:The national inspection programme using BASCD criteria was extended...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2010.723
更新日期:2010-08-28 00:00:00
abstract::Implant surgery protocols differ slightly with individual systems. However, basic surgical principles are required to ensure successful osseointegration of the implant in the correct location which allows good aesthetics and loading. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4800294
更新日期:1999-10-23 00:00:00
abstract::Part IV of this series introduced the idea that the value a patient places on an outcome has an important influence on the decision making process. This article considers this concept further. It argues that dentists should assess a patient's preferences and consider these before deciding on a treatment option. The ar...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808720
更新日期:1995-03-25 00:00:00
abstract::The objective of this case report is to illustrate the diagnosis and classification of periodontitis according to the 2017 classification system as recommended in the British Society of Periodontology (BSP) implementation plan. We describe two cases in the form of a pair of siblings, who developed periodontitis very e...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2019.2
更新日期:2019-01-11 00:00:00
abstract:OBJECTIVES:To investigate the short- and long-term career aspirations and barriers to postgraduate study of recently qualified vocational dental practitioners (VDPs). METHOD:One hundred and eight vocational dental practitioners in London were asked to complete a questionnaire survey. RESULTS:The questionnaires were c...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.779
更新日期:2007-09-01 00:00:00
abstract::The authors assert that those with oral lichen planus should be screened for hepatitis C infection to expedite diagnosis. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.449
更新日期:2017-05-26 00:00:00
abstract:OBJECTIVES:To investigate whether a standard Resuscitation Council (UK) ALS course is appropriate for primary care dentists or whether a course should be specifically designed for dentists. DESIGN:Opinions canvassed by pre-course expectation and post-course evaluation questionnaires. SUBJECTS:23 West Pennine primary ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4800523
更新日期:2000-05-13 00:00:00
abstract:OBJECTIVES:To assess changes in dental team knowledge and awareness about domestic violence following attendance at a brief training intervention. MATERIALS AND METHODS:Seventy-five dental hospital staff at the University of Manchester Dental Hospital attended a two-hour session delivered by Manchester's City Wide NHS...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4814232
更新日期:2006-11-25 00:00:00
abstract::The difference between paediatric dentistry and most other branches of dentistry is that in the child the occlusion is changing. Consequently 'Good Occlusal Practice' in children is a matter of making the right clinical decisions for the future occlusion. The clinician needs to be able to predict the influence that di...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4801261a
更新日期:2001-12-22 00:00:00
abstract::There are certain advantages to restoring a complete arch simultaneously, however, attempting to do this requires that the dentist maintains control during all stages of treatment. Maintaining control alleviates the preassure of time, which in turn allows for precision to be obtained at all clinical and laboratory sta...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2008.3
更新日期:2008-01-26 00:00:00