Abstract:
:This paper reviews the clinical pharmacology, efficacy and safety of the novel antipsychotic drug aripiprazole. All published citations regarding aripiprazole were reviewed using a Medline((R)) search (completed for citations through mid-year, 2002). In addition, abstracts from recent scientific meetings presenting data not yet published (nor peer-reviewed) were reviewed. Aripiprazole has a unique mechanism of action as a dopamine D2 partial agonist, serotonin 5-HT(1A) partial agonist and serotonin 5-HT(2A) antagonist. Like other new antipsychotics, aripiprazole has the profile of an atypical agent, with efficacy in the treatment of positive and negative symptoms of psychosis as well as mood symptoms, a low rate of neurological side effects and no significant adverse effect on serum prolactin concentrations. In addition, aripiprazole was not associated with significant weight gain or QTc prolongation in both acute and long-term treatment trials.
journal_name
Expert Opin Investig Drugsjournal_title
Expert opinion on investigational drugsauthors
Keck PE Jr,McElroy SLdoi
10.1517/13543784.12.4.655subject
Has Abstractpub_date
2003-04-01 00:00:00pages
655-62issue
4eissn
1354-3784issn
1744-7658journal_volume
12pub_type
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journal_title:Expert opinion on investigational drugs
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