Ulcerative colitis in a patient with Wiskott-Aldrich syndrome.

Abstract:

:A 30-year-old man with underlying Wiskott-Aldrich syndrome, which is a rare X-linked congenital immunodeficiency syndrome characterized by recurrent infections, thrombopenia, eczema and hematopoietic malignancies, presented with bloody diarrhea. Endoscopic and histological evaluation was compatible with ulcerative colitis. Congenital immune defects are paralleled by enterocolitis mimicking inflammatory bowel disease in a substantial number of patients. Despite therapy with prednisolone and 5-ASA compounds, the patient described here experienced a relapse of the colitis twice. Subsequently a JC virus infection of the central nervous system was diagnosed, and he died due to progressive multifocal leukencephalopathy.

journal_name

Endoscopy

journal_title

Endoscopy

authors

Folwaczny C,Ruelfs C,Walther J,König A,Emmerich B

doi

10.1055/s-2002-34272

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

840-1

issue

10

eissn

0013-726X

issn

1438-8812

journal_volume

34

pub_type

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