Abstract:
:The D/I (deletion, D, insertion, I) polymorphism of the angiotensin-converting enzyme (ACE) gene has been extensively studied for its association with a number of cardiovascular and other disease states. However, its potential association with differential clinical efficacy of ACE inhibitors (ACE-I) administered to patients who had suffered a myocardial infarction (MI), i.e. the prevention of left ventricular (LV) remodeling, has so far not been specifically studied. The aim of the study was to investigate whether the D/I polymorphism of the ACE gene is associated with the incidence of post-MI LV remodeling in patients drawn from the 'Healing and Early Afterload Reducing Therapy' (HEART) Study. The ACE D/I polymorphism was characterized by the polymerase chain reaction (PCR) in 265 subjects from the 'Healing and Early Afterload Reducing Therapy' Study, a double-blind, placebo-controlled trial with the objective of determining whether early or delayed administration of the ACE-I, ramipril, in patients with acute anterior wall MI would be optimal in reducing LV enlargement. Selected frequencies for the ACE D and I alleles were 0.59 and 0.41 (placebo-high dose group), 0.56 and 0.44 (low dose-low dose group), and, 0.60 and 0.40 (high dose-high dose group), respectively. All observed genotype frequencies were in Hardy-Weinberg equilibrium. There was no evidence for an association between genotype and outcome regarding LV size or function, nor with the initial blood pressure response after ACE-I administration (adjusted for covariates). Our data provide no evidence for an association of the ACE D/I polymorphism with the risk of LV remodeling post-MI in the presence of ACE-I therapy, and therefore do not suggest that differential clinical efficacy of ACE-inhibitors is related to this genetic marker.
journal_name
Clin Genetjournal_title
Clinical geneticsauthors
Zee RY,Solomon SD,Ajani UA,Pfeffer MA,Lindpaintner K,Heart investigators.doi
10.1034/j.1399-0004.2002.610104.xsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
21-5issue
1eissn
0009-9163issn
1399-0004pii
cge610104journal_volume
61pub_type
临床试验,杂志文章abstract::In an epidemiological study, infants identified at birth as having sex chromosome anomalies are enrolled in a voluntary, long term evaluations program. Case histories are presented of the first four boys in the series to have a 47,XXY karyotype. They have been followed from birth for 6 to 9 years, with physical and ps...
journal_title:Clinical genetics
pub_type: 杂志文章
doi:10.1111/j.1399-0004.1975.tb00357.x
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Array-comparative genomic hybridization (array-CGH) is a widely used technique to detect copy number variants (CNVs) associated with developmental delay/intellectual disability (DD/ID). AIMS:Identification of genomic disorders in DD/ID. MATERIALS AND METHODS:We performed a comprehensive array-CGH investiga...
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journal_title:Clinical genetics
pub_type: 杂志文章,评审
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abstract::Mutation of SLC26A4 is the most common cause of prelingual hearing loss in East Asia. Patients with SLC26A4 mutations have variable phenotypes ranging from non-syndromic hearing loss to Pendred syndrome. Here, we analyzed the correlation between genotype and various inner ear phenotypes and found a possible underlying...
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journal_title:Clinical genetics
pub_type: 杂志文章
doi:10.1111/j.1399-0004.1976.tb01573.x
更新日期:1976-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1399-0004.1978.tb04136.x
更新日期:1978-05-01 00:00:00
abstract::Disorders of the Ras/mitogen-activated protein kinase (MAPK) pathway have an overlapping skeletal phenotype (e.g. scoliosis, osteopenia). The Ras proteins regulate cell proliferation and differentiation and neurofibromatosis type 1 (NF1) individuals have osteoclast hyperactivity and increased bone resorption as measur...
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journal_title:Clinical genetics
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更新日期:1997-06-01 00:00:00
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journal_title:Clinical genetics
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:1975-07-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:1983-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
doi:10.1111/j.1399-0004.1988.tb03480.x
更新日期:1988-06-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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更新日期:1997-11-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:1981-05-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:1979-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-04-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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journal_title:Clinical genetics
pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
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