Abstract:
:Endothelin-1 (ET-1) is enhanced and has been demonstrated to be a prognostic marker in patients with advanced stages of heart failure, acute ischaemic syndromes, myocardial infarction and pulmonary hypertension. Activation of the endothelin (ET) system is associated with adverse haemodynamic consequences in patients with congestive heart failure and results in coronary vasoconstriction in patients with coronary artery disease (CAD). Moreover, ET-1 raises blood pressure, induces vascular and myocardial hypertrophy and acts as the natural counterpart of nitric oxide (NO), which exerts vasodilating, antithrombotic and antiproliferative effects. This article reviews recently completed and ongoing clinical trials examining the effects of ET receptor antagonists in patients with heart failure, CAD, arterial hypertension and pulmonary hypertension.
journal_name
Expert Opin Investig Drugsjournal_title
Expert opinion on investigational drugsauthors
Neunteufl T,Berger R,Pacher Rdoi
10.1517/13543784.11.3.431subject
Has Abstractpub_date
2002-03-01 00:00:00pages
431-43issue
3eissn
1354-3784issn
1744-7658journal_volume
11pub_type
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journal_title:Expert opinion on investigational drugs
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