Abstract:
:Recombination was measured across nine intervals in the human beta-globin gene cluster by single-sperm analysis. A recombination fraction of approximately 0.9% was calculated across an approximately 11 kb region using a new method to estimate recombination fractions from single-sperm typing data. No recombination was detected in an adjacent approximately 90 kb region that extends upstream of the beta-globin cluster. These data are consistent with previous estimates based on population genetic analysis, and suggest a recombination rate of nearly two orders of magnitude greater than the genome average of approximately 1 cM/Mb. Because recombination hot spots will destroy linkage disequilibrium across small physical regions, knowledge about the location and strength of such hot spots could be extremely valuable for genetic association studies.
journal_name
Hum Mol Genetjournal_title
Human molecular geneticsauthors
Schneider JA,Peto TE,Boone RA,Boyce AJ,Clegg JBdoi
10.1093/hmg/11.3.207subject
Has Abstractpub_date
2002-02-01 00:00:00pages
207-15issue
3eissn
0964-6906issn
1460-2083journal_volume
11pub_type
杂志文章abstract::A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study. ERAP1 is highly polymorphic with strong linkage disequilibrium evident across the gene. We therefore conduc...
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更新日期:1998-11-01 00:00:00
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