A possible role of hypervariable region 1 quasispecies in escape of hepatitis C virus particles from neutralization.

abstract：:Mixed cryoglobulinaemia, when not secondary to other well-defined immunological disorders, is commonly associated with hepatitis C virus (HCV) infection. However, a minority of cases lack evidence of HCV infection and are, therefore, defined as 'true essential' mixed cryoglobulinaemias. We thoroughly investigated thre...

journal_title：Journal of viral hepatitis

authors： Casato M,Lilli D,Donato G,Granata M,Conti V,Del Giudice G,Rivanera D,Scagnolari C,Antonelli G,Fiorilli M

更新日期：2003-11-01 00:00:00

abstract：:Flares in chronic hepatitis B are often detrimental but sometimes lead to sustained immune control and disease remission. The aim of this study was to estimate the frequency of hepatitis flares which occur during and/or after cessation of nucleos(t)ide analogue (NA) therapy, and to assess their outcomes. In a single c...

journal_title：Journal of viral hepatitis

authors： Zhang NP,Reijnders JG,Perquin M,Hansen BE,Janssen HL

更新日期：2011-07-01 00:00:00

abstract：:GS-9857, an inhibitor of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A, demonstrates potent activity against HCV genotypes 1-6 and improved coverage against commonly encountered NS3 resistance-associated variants (RAVs). In this study, the safety, tolerability, antiviral activity and pharmacokinetics (PK...

journal_title：Journal of viral hepatitis

authors： Rodriguez-Torres M,Glass S,Hill J,Freilich B,Hassman D,Di Bisceglie AM,Taylor JG,Kirby BJ,Dvory-Sobol H,Yang JC,An D,Stamm LM,Brainard DM,Kim S,Krefetz D,Smith W,Marbury T,Lawitz E

更新日期：2016-08-01 00:00:00

abstract：:We aimed to compare the evolution of estimated glomerular filtration rate (eGFR) in HIV-, HIV-HBV- and HBV-infected patients treated with tenofovir disoproxil fumarate (TDF). Three groups of patients receiving TDF > 12 months were recruited: 194 HIV-infected patients, 85 HIV-HBV-coinfected patients and 50 HBV-infected...

journal_title：Journal of viral hepatitis

authors： Pradat P,Le Pogam MA,Okon JB,Trolliet P,Miailhes P,Brochier C,Maynard M,Bailly F,Zoulim F,Cotte L

更新日期：2013-09-01 00:00:00

abstract：:Chronic infection with the hepatitis C virus is a major health problem. Conventional therapy, with interferon-alpha is effective in only a minority of patients. The failure of current treatments has led to a major initiative to identify new antiviral agents. In the absence of a tissue culture model for hepatitis C inf...

journal_title：Journal of viral hepatitis

authors： Clarke BE

更新日期：1995-01-01 00:00:00

abstract：:We assessed the efficacy of prolonged interferon-alpha (IFN) therapy in children with chronic hepatitis caused by hepatitis delta virus (HDV) by treating 26 paediatric cases with IFN-alpha 2b (5 MU m-2, then 3 MU m-2 three times weekly for 12 (medium-term group MTG) or 24 months (long-term group, LTG). Compliance and ...

journal_title：Journal of viral hepatitis

authors： Di Marco V,Giacchino R,Timitilli A,Bortolotti F,Crivellaro C,Calzia R,Iannuzzi C,Prestileo T,Vajro P,Nebbia G,Stringhi C,Rosina F,Biassoni D,Callea F,Rizzetto M,Craxi A

更新日期：1996-05-01 00:00:00

abstract：:Approximately 30% of patients with chronic HCV infection have persistently normal ALT levels. Although formerly referred to as 'healthy' or 'asymptomatic' HCV carriers, and thus historically excluded from antiviral treatment, it has now become clear that the majority of these patients have some degree of histological ...

journal_title：Journal of viral hepatitis

authors： Puoti C,Guarisco R,Spilabotti L,Bellis L,Mitidieri Costanza O,Dell' Unto O,Elmo MG

更新日期：2012-04-01 00:00:00

abstract：:Reports have described a decrease in glomerular filtration rate (eGFR) associated with tenofovir disoproxil fumarate (TDF) use in HIV positive individuals. However, no study has examined renal function over a prolonged period in HIV/hepatitis B virus (HBV) co-infected patients. We assessed the long-term durability and...

journal_title：Journal of viral hepatitis

authors： Tan LK,Gilleece Y,Mandalia S,Murungi A,Grover D,Fisher M,Atkins M,Nelson M

更新日期：2009-07-01 00:00:00

abstract：:Despite the availability of effective therapy for hepatitis C virus (HCV) infection, there are little data on the uptake of treatment. We evaluated factors associated with HCV infection and the uptake of HCV treatment in a large community-based inner city cohort in Vancouver, Canada. The Community Health and Safety Ev...

journal_title：Journal of viral hepatitis

authors： Grebely J,Raffa JD,Lai C,Krajden M,Kerr T,Fischer B,Tyndall MW

更新日期：2009-05-01 00:00:00

abstract：:Although long-term antiviral treatment with nucleos(t)ide analogs (NAs) can lead to histological improvement in patients with chronic hepatitis B (CHB), a substantial proportion of patients still fail to achieve regression of fibrosis. Here, we investigated whether peginterferon alpha (Peg-IFNα） add-on therapy had ben...

journal_title：Journal of viral hepatitis

authors： Li G,Zhang Q,Yu Y,Qiu C,Zhang H,Zhang M,Song Z,Yang Y,Hong J,Lu J,Li N,Tang Q,Xu L,Wang X,Zhang W,Chen Z

更新日期：2019-07-01 00:00:00

abstract：:An estimated incidence of hepatocellular carcinoma (HCC) in Mongolia is currently one of the highest in the world. According to previous reports, the sero-prevalence of hepatitis B (HBV) and hepatitis C (HCV) viruses in general population of the country is very high (HBV, 10% and HCV, 15%, respectively). Moreover, the...

journal_title：Journal of viral hepatitis

authors： Kurbanov F,Tanaka Y,Elkady A,Oyunsuren T,Mizokami M

更新日期：2007-09-01 00:00:00

abstract：:Hepatitis B e antigen (HBeAg)-negative infections are an unusual form of chronic hepatitis B virus (HBV) infection in which viral replication and liver damage persist despite antibodies against HBeAg. This form of HBV may be associated with fulminant hepatitis. The molecular basis for an HBeAg-minus phenotype has been...

journal_title：Journal of viral hepatitis

authors： Miyakawa Y,Okamoto H,Mayumi M

更新日期：1997-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that regulates gene expression of inflammatory mediators in liver injury. Hepatitis B virus (HBV) suppresses the PPAR gamma-mediated transactivation in liver cancerous cell lines. However, the role of PPAR gamma in patients with chroni...

journal_title：Journal of viral hepatitis

authors： Zhao Q,Fan YC,Zhao J,Gao S,Zhao ZH,Wang K

更新日期：2013-06-01 00:00:00

abstract：:No studies have reported the long-term effects of entecavir switching in patients with multidrug resistance who developed resistance after lamivudine/adefovir sequential therapy. We evaluated the efficacy of 96 weeks of entecavir therapy in patients with resistance to lamivudine/adefovir sequential therapy. In total, ...

journal_title：Journal of viral hepatitis

authors： Kwak MS,Choi JW,Lee JS,Kim KA,Suh JH,Cho YS,Won SY,Park BK,Lee CK

更新日期：2011-10-01 00:00:00

abstract：SUMMARY:A simian hepatitis A virus (HAV) was identified retrospectively in a faecal sample from a rhesus monkey in India, inoculated in 1995 with a faecal suspension from a suspected patient of non-A to E hepatitis. The monkey was in captivity for 2 years in one of the experimental primate facilities in western India b...

journal_title：Journal of viral hepatitis

authors： Arankalle VA,Ramakrishnan J

更新日期：2009-03-01 00:00:00

abstract：:For hepatitis B virus (HBV)-related chronic infection under treatment by nucleos(t)ide analogues (NUCs), HBsAg clearance is the ultimate therapeutic goal but very infrequent. We investigated how HBV envelope protein variability could lead to differential HBsAg clearance on NUCs. For 12 HBV genotype D patients receivin...

journal_title：Journal of viral hepatitis

authors： Velay A,Jeulin H,Eschlimann M,Malvé B,Goehringer F,Bensenane M,Frippiat JP,Abraham P,Ismail AM,Murray JM,Combet C,Zoulim F,Bronowicki JP,Schvoerer E

更新日期：2016-05-01 00:00:00

abstract：:To study the correlation between total Hepatitis C virus (HCV) Core antigen (Ag) and HCV-RNA, and to assess the proficiency of HCV Core Ag testing in monitoring and predicting virologic response during and after pegylated interferon (PEG-IFN) and ribavirin combination therapy. A total of 307 samples from treated and u...

journal_title：Journal of viral hepatitis

authors： Maynard M,Pradat P,Berthillon P,Picchio G,Voirin N,Martinot M,Marcellin P,Trepo C

更新日期：2003-07-01 00:00:00

abstract：:The efficacy of lamivudine re-treatment in chronic hepatitis B (CHB) patients who relapse after HBeAg seroconversion with lamivudine has not been investigated. The aim of this study was to evaluate the efficacy of lamivudine re-treatment in relapsed patients. Among 192 patients who had achieved HBeAg seroconversion wi...

journal_title：Journal of viral hepatitis

authors： Shin JW,Park NH,Park JH,Park JH,Jeong ID,Bang SJ,Joo KR,Kim DH

更新日期：2005-07-01 00:00:00

abstract：:Although there are no dietary restrictions recommended in acute viral hepatitis (AVH), there is an altered food intake, probably because of perceptions and traditional nutritional practices, leading to sub-optimal intake and poorer clinical outcome. Therefore, we aimed to determine nutritional intake of AVH patients b...

journal_title：Journal of viral hepatitis

authors： Sathiaraj E,Chutke M,Mahurkar S,Nagaraja Rao P,Nageshwar Reddy D

更新日期：2010-05-01 00:00:00

abstract：:Transient elastometry (TE) could provide a more accurate evaluation of the frequency and risk factors of liver fibrosis in hepatitis C virus (HCV) infection than that based on biopsy. The aim of this study was to assess the prevalence of and factors associated with significant liver fibrosis in a large population of H...

journal_title：Journal of viral hepatitis

authors： Pineda JA,González J,Ortega E,Tural C,Macías J,Griffa L,Burgos A,Grafihco Study Team.

更新日期：2010-10-01 00:00:00

abstract：:The risk of perinatal transmission of hepatitis C virus (HCV) from a cohort of 95 human immunodeficiency virus (HIV)-negative intravenous drug users (IVDU) is described, 89 of whom were positive for antibodies to HCV (anti-HCV). Infection, defined as the presence of HCV RNA in a serum sample collected from an infant a...

journal_title：Journal of viral hepatitis

authors： Spencer JD,Latt N,Beeby PJ,Collins E,Saunders JB,McCaughan GW,Cossart YE

更新日期：1997-01-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV)-infected patients with liver failure have a poor prognosis, and no satisfactory biomarkers are available for diagnosis before the end-stage. We explored serum peptide profiling for diagnosis and prediction of progression to liver failure in HBV-infected patients. Serum samples (164) fro...

journal_title：Journal of viral hepatitis

authors： Han T,Liu H,Yu ZL,Li J,Wang L,Xiao SX,Li Y,Yu ML

更新日期：2010-03-01 00:00:00

abstract：:To assess the prevalence of hepatitis delta virus (H delta V) in northern India, 204 adult patients with acute and chronic liver disease who were positive for hepatitis B virus (HBV) markers were screened for anti-H delta V antibody by enzyme-linked immunosorbent assay (ELISA). Anti-H delta V antibodies were positive ...

journal_title：Journal of viral hepatitis

authors： Singh V,Goenka MK,Bhasin DK,Kochhar R,Singh K

更新日期：1995-01-01 00:00:00

abstract：:It is unknown whether dynamic changes of liver stiffness measurement (LSM) can predict the reversibility of fibrosis. Therefore, we evaluated the utility of LSM changes in predicting histological changes of fibrosis in patients with chronic hepatitis B (CHB) on antiviral therapy. In a prospective cohort of CHB patient...

journal_title：Journal of viral hepatitis

authors： Kong Y,Sun Y,Zhou J,Wu X,Chen Y,Piao H,Lu L,Ding H,Nan Y,Jiang W,Xu Y,Xie W,Li H,Feng B,Shi G,Chen G,Li H,Zheng H,Cheng J,Wang T,Liu H,Lv F,Shao C,Mao Y,Sun J,Chen T,Han T,Han Y,Wang L,Ou X,Zha

更新日期：2019-05-01 00:00:00

abstract：:Morbidity and mortality attributable to chronic hepatitis C virus (HCV) infection are increasing in many countries as the infected population ages. Models were developed for 15 countries to quantify and characterize the viremic population, as well as estimate the number of new infections and HCV related deaths from 20...

journal_title：Journal of viral hepatitis

authors： Hatzakis A,Chulanov V,Gadano AC,Bergin C,Ben-Ari Z,Mossong J,Schréter I,Baatarkhuu O,Acharya S,Aho I,Anand AC,Andersson MI,Arendt V,Arkkila P,Barclay K,Bessone F,Blach S,Blokhina N,Brunton CR,Choudhuri G,Cisneros

更新日期：2015-01-01 00:00:00

abstract：:Herpes simplex virus (HSV) hepatitis is a rare and potential life-threatening disease. The diagnosis of HSV hepatitis is hampered by its indifferent clinical presentation, which necessitates confirmatory laboratory data to identify HSV in the affected liver. However, liver biopsies are often contraindicated in the con...

journal_title：Journal of viral hepatitis

authors： Beersma MF,Verjans GM,Metselaar HJ,Osterhaus AD,Berrington WR,van Doornum GJ

更新日期：2011-04-01 00:00:00

abstract：:There are few extant studies on the prevalence of HBV infection in couples preparing for pregnancy. We assessed the prevalence of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in couples preparing for pregnancy in rural China, and the association between HBV prevalence and the statuses of HBsAg...

journal_title：Journal of viral hepatitis

authors： Liu J,Zhang S,Wang Q,Shen H,Zhang M,Zhang Y,Yan D,Liu M

更新日期：2017-08-01 00:00:00

abstract：:Primary or secondary failure of adefovir dipivoxil (ADV) therapy of chronic hepatitis B is not infrequent. The reasons for suboptimal responses are not well defined. In HIV and hepatitis C virus infection, failure of antiviral drug therapy has been linked with low blood drug levels. We have studied 20 well-defined pat...

journal_title：Journal of viral hepatitis

authors： Deterding K,Naesens L,Buti M,Janssen H,Kirschner J,Guerrero A,Reijnders J,Neyts J,Zoulim F,Wedemeyer H

更新日期：2011-07-01 00:00:00

abstract：:Hepatitis delta virus (HDV) is a serious cause of liver-related morbidity and mortality. Coexistent infection with HDV tends to aggravate the course of hepatitis B virus (HBV)-associated liver disease. The aim of this study was to determine the prevalence of HDV infection among patients chronically infected with HBV i...

journal_title：Journal of viral hepatitis

authors： Bahcecioglu IH,Aygun C,Gozel N,Poyrazoglu OK,Bulut Y,Yalniz M

更新日期：2011-07-01 00:00:00

abstract：:Hepatitis Be antigen (HBeAg)-negative chronic hepatitis B (CHB) is associated with hepatitis B virus (HBV) variants harbouring changes in the precore region. Most commonly, a G to A point mutation at nucleotide 1896 (m1896) creates a novel translation stop codon that prevents HBeAg production. In the Mediterranean reg...

journal_title：Journal of viral hepatitis

authors： Laras A,Koskinas J,Avgidis K,Hadziyannis SJ

更新日期：1998-07-01 00:00:00