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Evidence of linkage with HLA-DR in DRB1*15-negative families with multiple sclerosis.

Abstract：

:The importance of the HLA-DR locus to multiple sclerosis (MS) susceptibility was assessed in 542 sib pairs with MS and in their families. By genotyping 1,978 individuals for HLA-DRB1 alleles, we confirmed the well-established association of MS with HLA-DRB1*15 (HLA-DRB1*1501 and HLA-DRB5*0101), by the transmission/disequilibrium test (chi2=138.3; P<.0001). We obtained significant evidence of linkage throughout the whole data set (mlod=4.09; 59.9% sharing). Surprisingly, similar sharing was also observed in 58 families in which both parents lacked the DRB1*15 allele (mlod=1.56; 62.7% sharing; P=.0081). Our findings suggest that the notion that HLA-DRB1*15 is the sole major-histocompatibility-complex determinant of susceptibility in northern-European populations with MS may be incorrect. It remains possible that the association of MS with HLA-DRB1*15 is due to linkage disequilibrium with a nearby locus and/or to the presence of disease-influencing allele(s) in DRB1*15-negative haplotypes.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Ligers A,Dyment DA,Willer CJ,Sadovnick AD,Ebers G,Risch N,Hillert J,Canadian Collaborative Study Groups.

doi

10.1086/323480

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

900-3

issue

4

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)61147-1

journal_volume

69

pub_type

杂志文章

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