Abstract:
OBJECTIVES:The reason for the association between air pollution and risk of cardiovascular diseases is unknown. The hypothesis was examined that daily concentrations of air pollution are associated with daily concentrations of fibrinogen, a risk factor for cardiovascular disease. METHODS:Data on concentrations of plasma fibrinogen for 4982 male and 2223 female office workers, collected in a cross sectional survey in London between September 1991 and May 1993, were combined with data on concentrations of air pollution during the day of blood sampling and during the 3 preceding days. RESULTS:After adjustment for weather and other confounding factors, an increase in the 24 hour mean NO(2) during the previous day from the 10th to the 90th percentile (61.7 microg/m(3)) was associated with a 1.5% (95% confidence interval (95% CI) 0.4% to 2.5%) higher fibrinogen concentration. The respective increase for CO (1.6 mg/m(3)) was 1.5% (95% CI 0.5%, 2.5%). These associations tended to be stronger in the warm season (April to September). Significant associations were found for black smoke and particulate matter of diameter 10 microm (PM(10)) only in the warm season. No association with fibrinogen was found for SO(2) or ozone. CONCLUSIONS:The short term association between air pollution, possibly from traffic, and risk of cardiovascular events may be at least partly mediated through increased concentrations of plasma fibrinogen, possibly due to an inflammatory reaction caused by air pollution.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Pekkanen J,Brunner EJ,Anderson HR,Tiittanen P,Atkinson RWdoi
10.1136/oem.57.12.818subject
Has Abstractpub_date
2000-12-01 00:00:00pages
818-22issue
12eissn
1351-0711issn
1470-7926journal_volume
57pub_type
杂志文章abstract:AIMS:To determine obstacles for return-to-work in disability management of low back pain patients sicklisted for 3-4 months. METHODS:A cohort of 467 low back pain patients sicklisted for 3-4 months was recruited. A questionnaire was sent to their occupational physicians (OPs) concerning the medical management, obstacl...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.11.729
更新日期:2002-11-01 00:00:00
abstract::A survey was carried out on respiratory symptoms and skin prick test response to common allergens (atopy), storage mites, and occupational allergens among 226 bakers and pastry makers from 105 small businesses in northern Italy. Atopy was present in 54 workers (23.4%); 40 workers (17.7%) were skin positive to at least...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.8.548
更新日期:1994-08-01 00:00:00
abstract:AIM:To determine the prevalence of chronic fatigue syndrome (CFS)-like caseness in the working population. METHODS:Using data from the prospective Maastricht Cohort Study on Fatigue at Work, the prevalence and incidence of CFS-like cases (employees meeting research criteria for CFS) were determined among 5499 employee...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.008912
更新日期:2004-05-01 00:00:00
abstract::Respiratory symptoms and ventilatory capacity were studied in a group of 288 workers (259 women and 29 men) employed in a confectionery plant. A group of workers (96 women and 31 men) not exposed to confectionery manufacture were also studied as controls. The prevalence of chronic respiratory symptoms was higher in ex...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.7.435
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:Depressive symptoms are associated with sickness absence, work disability and unemployment, but little is known about worklife expectancy (WLE). This study investigates the impact of depressive symptoms on the WLE of a large sample of Danish employees. METHODS:We used occupational health survey data of 11 96...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-105961
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Fetal growth restriction has been inconsistently associated with maternal exposure to elevated levels of traffic-related air pollution. OBJECTIVE:We investigated the relationship between an individualised measure of fetal growth and maternal exposure to a specific marker for traffic-related air pollution. ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100509
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Commercial airline crew is one of the occupational groups with the highest exposures to ionising radiation. Crew members are also exposed to other physical risk factors and subject to potential disruption of circadian rhythms. METHODS:This study analyses mortality in a pooled cohort of 93 771 crew members f...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101395
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To explore the relationship between occupations and specific occupational exposures and oesophageal cancer (OC) by histological type. METHODS:A multicentre hospital-based case-control study was conducted in two Mediterranean provinces of Spain. Occupational, sociodemographic and lifestyle information was col...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2007.037929
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:Many residents in Beijing use disposable face masks in an attempt to protect their health from high particulate matter (PM) concentrations. Retail masks may be certified to local or international standards, but their real-life performance may not confer the exposure reduction potential that is marketed. This...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104765
更新日期:2018-06-01 00:00:00
abstract:AIMS:(1) To develop a transparent and broadly applicable method for assessing occupational safety and health (OSH) programmes or management systems; (2) to assess OSH programmes in a sample of manufacturing worksites; and (3) to determine whether a management focused occupational health intervention results in greater ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.011718
更新日期:2004-08-01 00:00:00
abstract:AIMS:To test whether (1) physically demanding work is less frequent for older than younger employees, and whether (2) the association of physically demanding work with decline of physical functioning is stronger for older employees than their younger counterparts. The gender differences in these associations were exami...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014035
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:The Stand Back study evaluated the feasibility and effects of a multicomponent intervention targeting reduced prolonged sitting and pain self-management in desk workers with chronic low back pain (LBP). METHODS:This randomised controlled trial recruited 27 individuals with chronic LBP, Oswestry Disability In...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2017-104732
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2016-104168
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:Night shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses' Health Study (NHS) and NHSII. METHODS:A total of ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106016
更新日期:2019-10-01 00:00:00
abstract::Complex and dynamic physiologic processes underlie the exposure-response relations that occupational and environmental epidemiologists study. Simple summary measures of exposure such as the average, cumulative exposure, or duration of exposure, can be applied suitably in exposure-response analyses in many instances. H...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.030031
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH g...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.045500
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:(1) To investigate the association between temperature and work-related injuries and (2) to identify groups of workers at high risk of work-related injuries in hot environments in Adelaide, South Australia. METHODS:Workers' compensation claims in Adelaide, South Australia for 2001-2010 were used. The relati...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101584
更新日期:2014-04-01 00:00:00
abstract::: Physically demanding occupations (ie, military, firefighter, law enforcement) often use fitness tests for job selection or retention. Despite numerous individual studies, the relationship of these tests to job performance is not always clear. : This review examined the relationship by aggregating previously reported...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/oemed-2016-103684
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:Occupational dust exposure has been associated with accelerated lung function decline, which in turn is associated with overall morbidity and mortality. In the current study, we assess potential benefits on lung function of hypothetical interventions that would reduce occupational exposure to fine particulate...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-105908
更新日期:2019-12-01 00:00:00
abstract::Male Wistar rats were exposed to two types of magnesium sulphate whiskers by inhalation for six hours a day, five days a week, for four weeks (sub-chronic study), or for one year (chronic study) to clarify the biological effects of the whiskers. There were few whiskers detected in the rat lungs even at one day after t...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.7.492
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:The pathogenesis of cataract is influenced by a number of factors including oxidative stress. Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors. It is important for detoxification of xenobiotics in order to protect tissues from oxidative damage...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.022343
更新日期:2006-07-01 00:00:00
abstract:INTRODUCTION:The current definition of chronic obstructive pulmonary disease (COPD) associates persistent airflow limitation and chronic respiratory symptoms. Agricultural work has been associated with an increased risk of developing COPD, but the prevalence and definition of the disease vary greatly between studies. T...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oemed-2018-105310
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To examine the relation between exposure to acid anhydrides and the risk of developing immediate skin prick test responses to acid anhydride human serum albumin (AA-HSA) conjugates or work related respiratory symptoms; to assess whether these relations are modified by atopy or smoking. METHODS:A cohort of 5...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.10.684
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVES:To investigate the relation with a case-control study between symptomatic osteochondrosis or spondylosis of the lumbar spine and cumulative occupational exposure to lifting or carrying and to working postures with extreme forward bending. METHODS:From two practices and four clinics were recruited 229 male p...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.11.735
更新日期:2001-11-01 00:00:00
abstract::Four workers chronically exposed to elemental mental mercury in a lampsocket manufacturing factory were studied. The clinical manifestations were severe in one, mild in another, and suspicious in the remaining two. Correlation between severity of clinical features and increased urinary mercury concentrations was found...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.4.267
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVES:To describe the relation with age of risk of reported injury after a fall among women at work in two countries, the United Kingdom and Sweden, with particular emphasis on fractures, and to interpret these data. METHODS:Rates of accidents compiled under the national reporting regulations of each country duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.11.785
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:To better understand the relations between occupational exposure, blood antioxidant enzyme activities, total plasma antioxidant concentration, and the severity of coal workers' pneumoconiosis (CWP). METHODS:Blood samples were obtained from miners without CWP exposed to low dust concentrations for > or = 4 y...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.8.533
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVES:This paper describes findings from the study of chronic bronchitis (CB) incidence after occupational exposure to ionising radiation among workers employed at Russian Mayak Production Association (PA) during 1948 and 1982 and followed up until 2008 based on 'Mayak Worker Dosimetry System 2008'. METHODS:Analy...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-103283
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:To determine the mortality from non-respiratory cancers by work area among active and retired male workers of the German rubber industry. METHODS:A cohort of 11,633 male German workers was followed up for mortality from 1 January 1981 to 31 December 1991. Cohort members were active (n = 7536) or retired (n ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.5.325
更新日期:1998-05-01 00:00:00
abstract::Worldwide, millions of office workers use a computer. Reports of adverse health effects due to computer use have received considerable media attention. This systematic review summarises the evidence for a relationship between the duration of work time spent using the computer and the incidence of hand-arm and neck-sho...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.2006.026468
更新日期:2007-04-01 00:00:00