Abstract:
:The Ligand Design (LUDI) approach has been used in order to design leucine aminopeptidase inhibitors, predict their activity and analyze their interactions with the enzyme. The investigation was based on the crystal structure of bovine lens leucine aminopeptidase (LAP) complexed with its inhibitor--the phosphonic acid analogue of leucine (LeuP). More than 50 potential leucine aminopeptidase inhibitors have been obtained, including the most potent aminophosphonic LAP inhibitors with experimentally known activity, which have been the subject of more detailed studies. A reasonable agreement between theoretical and experimental activities has been obtained for most of the studied inhibitors. Our results confirm that LUDI is a powerful tool for the design of enzyme inhibitors as well as in the prediction of their activity. In addition, for inhibitor-active site interactions dominated by the electrostatic effects it is possible to improve binding energy estimates by using a more accurate description of inhibitor charge distribution.
journal_name
J Comput Aided Mol Desjournal_title
Journal of computer-aided molecular designauthors
Grembecka J,Sokalski WA,Kafarski Pdoi
10.1023/a:1008189716955subject
Has Abstractpub_date
2000-08-01 00:00:00pages
531-44issue
6eissn
0920-654Xissn
1573-4951journal_volume
14pub_type
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journal_title:Journal of computer-aided molecular design
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