Abstract:
:Cutaneous GVHD is histologically similar to eruptions induced by drugs containing a sulfhydryl group. The levels of interleukin-2 and interleukin-2 receptor were determined in a group of patients undergoing bone marrow transplantation (BMT) without graft-versus-host disease or any other complications and in a group with cutaneous graft-versus-host disease (GVHD) alone. In patients who only developed cutaneous GVHD, both interleukin-2 and inter-leukin-2 receptor levels were elevated when the disease was evident. As the elevation of these parameters became more marked, the grade of cutaneous graft versus-host disease also increased. In some patients, only one of the two parameters was elevated and the grade of graft-versus-host disease was low or no skin manifestations were seen. These findings suggest that interleukin-2 and interleukin-2 receptor act together in the development of cutaneous GVHD. This study also showed that the mechanism of cutaneous GVHD resembles that involved in the induction of eruptions by sulfhydryl-containing drugs.
journal_name
Hematologyjournal_title
Hematology (Amsterdam, Netherlands)authors
Takatsuka H,Takemoto Y,Yamada S,Mori A,Wada H,Fujimori Y,Okamoto T,Kanamaru A,Kakishita Edoi
10.1080/10245330290020135subject
Has Abstractpub_date
2002-02-01 00:00:00pages
55-7issue
1eissn
1024-5332issn
1607-8454pii
XPWJK3B48DVF2D2Fjournal_volume
7pub_type
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