Radiation Treatment Deintensification for HPV-Associated Oropharyngeal Cancer.

abstract：:Neovascular age-related macular degeneration is the most common cause of severe irreversible blindness in the Western world in people older than age 50. Laser photocoagulation is the only proven treatment for this disease; however, fewer than 20% of patients are eligible for this treatment because the majority of chor...

journal_title：Seminars in radiation oncology

authors： Berson AM,Finger PT,Chakravarthy U

更新日期：1999-04-01 00:00:00

abstract：:In the broad field of radiation therapy optimization, both simple and complex problems have their origins in the interaction of the radiation beams with the biological structures of normal and malignant tissues of the human body. Therefore, it is no great surprise that many treatment optimization problems are best han...

journal_title：Seminars in radiation oncology

authors： Brahme A

更新日期：1999-01-01 00:00:00

abstract：:The rationale for the use of paclitaxel to treat brain tumors includes impressive activity in a wide array of chemotherapy-resistant solid tumors, in vitro and in vivo evidence of cytotoxicity against primary brain tumors, and a paucity of effective alternative agents. A review of published studies evaluating paclitax...

journal_title：Seminars in radiation oncology

authors： Glantz MJ,Chamberlain MC,Chang SM,Prados MD,Cole BF

更新日期：1999-04-01 00:00:00

abstract：:The goal of these National Cancer Institute-sponsored phase I trials is to determine the feasibility, toxicity, and pharmacokinetics of continuous-infusion (24 hr/d, 7 d/wk, 7 weeks total) intravenous paclitaxel combined with standard, curative-intent thoracic radiation therapy (XRT) for previously untreated, locally ...

journal_title：Seminars in radiation oncology

authors： Dowell JE,Sinard R,Yardley DA,Aviles V,Machtay M,Weber RS,Weinstein GS,Chalian AA,Carbone DP,Rosenthal DI

更新日期：1999-04-01 00:00:00

abstract：:Postmastectomy radiotherapy decreases threefold the risk of locoregional recurrences according to the results of many randomized trials and overviews. This risk is mainly related to the number of involved axillary nodes (ie, about 25%, 35%, and 55% at 10 years when 1 to 3, 4 to 9, and 10 or more nodes are involved). I...

journal_title：Seminars in radiation oncology

authors： Arriagada R,Rutqvist LE,Lê MG

更新日期：1999-07-01 00:00:00

abstract：:The treatment of cervical cancer has become increasingly sophisticated with evidence-based guidelines generated from randomized trials directing combined modality programs. The radiotherapeutic guidelines have been derived largely from single institutional experiences coupled with data from the Patterns of Care Studie...

journal_title：Seminars in radiation oncology

authors： Lanciano R

更新日期：2000-01-01 00:00:00

abstract：:The current data involving the use of prostate-specific antigen (PSA) in the radiotherapeutic management of localized prostatic cancer is reviewed. Controversies and ongoing debate notwithstanding, a number of general conclusions have been made. (1) PSA as a screening test has increased prostate cancer detection rates...

journal_title：Seminars in radiation oncology

authors： Russell KJ,Boileau MA

更新日期：1993-07-01 00:00:00

abstract：:Brachytherapy is a useful addition to external beam irradiation in the treatment of patients with head and neck cancer. Removeable implants are especially important in the treatment of neoplasms of the oral cavity (tongue, floor of mouth, buccal mucosa), orophrynx (tonsil, palate, and base tongue) and nasopharynx (int...

journal_title：Seminars in radiation oncology

authors： Goffinet DR

更新日期：1993-10-01 00:00:00

abstract：:This article reviews prospective randomized phase III studies that use chemotherapy and irradiation for the treatment of patients with carcinoma of the uterine cervix. Neoadjuvant chemotherapy has been administered in four separate trials. None of these has shown a benefit to neoadjuvant therapy compared with irradiat...

journal_title：Seminars in radiation oncology

authors： Grigsby PW

更新日期：1994-01-01 00:00:00

abstract：:The changes in normal tissues caused by radiotherapy must be monitored and recorded with the same care as is given to that of tumor control. The EORTC/RTOG system, the Chassagne glossary, and the new system recording the individual elements of morbidity have been used for this purpose and are valuable in clinical rese...

journal_title：Seminars in radiation oncology

authors： Dische S

更新日期：1994-04-01 00:00:00

abstract：:Recent studies in nonmetastatic cancer of the esophagus have shown improved local control and survival by the use of combined chemotherapy and radiation therapy compared with radiation only. This has been achieved by accepting an increased incidence of acute side effects, usually mucositis or myelosuppression, seconda...

journal_title：Seminars in radiation oncology

authors： Gaspar LE

更新日期：1994-07-01 00:00:00

abstract：:Dose-time-volume relationships are probably the most heatedly debated single item in radiation oncology, with virtually no clinical or radiobiologic aspect of this subject that is not contentious in some way. There is even less agreement among oncologists about the treatment of patients with metastatic breast cancer. ...

journal_title：Seminars in radiation oncology

authors： Kagan AR

更新日期：1994-10-01 00:00:00

abstract：:There have been significant advances in the treatment of small cell lung cancer during the past two decades. Systemic chemotherapy for extensive disease and combined modality therapy for limited small cell lung cancer has improved both quality and quantity of survival. In extensive disease, although the median surviva...

journal_title：Seminars in radiation oncology

authors： Einhorn LH 3rd

更新日期：1995-01-01 00:00:00

abstract：:This article reviews suggested recommendations and procedures for quality assurance and safety tests of computer-controlled medical accelerators and the associated high-tech ancillary devices such as asymmetric collimators, dynamic wedge, multileaf collimators, and on-line electronic portal imaging devices for treatme...

journal_title：Seminars in radiation oncology

authors： Purdy JA,Klein EE,Low DA

更新日期：1995-04-01 00:00:00

abstract：:Radiosurgery is a technique to deliver (in most cases) a single fraction of ionizing radiation, usually in the range of 10 to 25 Gy, to a precisely localized intracranial volume of pathological tissue. The radiobiological principles that govern the practice of single-fraction radiosurgery differ from those of conventi...

journal_title：Seminars in radiation oncology

authors： Shaw EG,Coffey RJ,Dinapoli RP

更新日期：1995-07-01 00:00:00

abstract：:This study demonstrates by an updated analysis of an ongoing prospective study that tumor oxygenation, as measured with a validated standardized polarographic needle electrode method before treatment, powerfully predicts the prognosis of patients receiving radiotherapy for intermediate and advanced stage cancer of the...

journal_title：Seminars in radiation oncology

authors： Höckel M,Schlenger K,Mitze M,Schäffer U,Vaupel P

更新日期：1996-01-01 00:00:00

abstract：:Radiotherapy represents one of the primary modalities in the treatment of patients with carcinoma of the lung. Despite significant medical advancements, the outcome of therapy (local control and survival) in patients with unresectable disease is still very disappointing. Although there are some indications in the lite...

journal_title：Seminars in radiation oncology

authors： Emami B

更新日期：1996-04-01 00:00:00

abstract：:Recommendations for the treatment of "poor prognosis" stages I and II Hodgkin's disease (HD) depend on the extent of staging. For centers that favor exploratory laparotomy and splenectomy, the standard treatment after negative surgical staging remains subtotal lymphoid irradiation. However, most centers recommend excl...

journal_title：Seminars in radiation oncology

authors： Cosset JM,Fermé C,Noordijk EM,Dubray BM,Thirion P,Henry-Amar M

更新日期：1996-07-01 00:00:00

abstract：:A knowledge of the biochemical and molecular basis of sensitivity to ionizing radiation can provide useful information regarding carcinogenesis, cancer susceptibility, and patient responses to radiotherapy. Various factors can influence radiosensitivity, including the induction, processing and manifestation of DNA dam...

journal_title：Seminars in radiation oncology

authors： Leadon SA

更新日期：1996-10-01 00:00:00

abstract：:An effective information system is an essential prerequisite to delivering quality patient care at competitive costs. From scheduling and billing to complex treatment machine control and verification, the quality of the information system strongly affects the efficiency and accuracy with which patient care is delivere...

journal_title：Seminars in radiation oncology

authors： Herman MG,Williams AL,Dicello JF

更新日期：1997-01-01 00:00:00

abstract：:The Patterns of Care Study (PCS) surveys for Hodgkin's disease have documented important correlations between treatment processes and patient outcome. Nationwide improvements in radiotherapy for Hodgkin's disease since 1973, such as routine use of extended fields (subtotal lymphoid irradiation) in patients with early ...

journal_title：Seminars in radiation oncology

authors： Smitt MC,Buzydlowski J,Hoppe RT

更新日期：1997-04-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a malignant tumor with a variety of clinical presentations requiring varied therapeutic approaches. Radiotherapy plays an important role in the treatment of many children with RMS arising in genitourinary (GU) sites. Although the majority of these children present with locally advanced diseas...

journal_title：Seminars in radiation oncology

authors： Breneman JC

更新日期：1997-07-01 00:00:00

abstract：:Combination chemotherapy has not been shown to be superior to single-agent 5-fluorouracil (5-FU) in the treatment of metastatic pancreatic cancer. Initial studies from Duke University suggest a role for radiation in the management of locally unresectable presentations of this disease. In vivo studies showed that 5-FU ...

journal_title：Seminars in radiation oncology

authors： Chakravarthy A,Abrams RA

更新日期：1997-10-01 00:00:00

abstract：:Radioimmunotherapy (RIT) is a promising new therapy for the treatment of a variety of malignancies. General principles of RIT are discussed, including important considerations in the selection of monoclonal antibodies (MAb) and radionuclides for RIT. Results of clinical trials using RIT for the treatment of lymphoma, ...

journal_title：Seminars in radiation oncology

authors： Knox SJ,Meredith RF

更新日期：2000-04-01 00:00:00

abstract：:For patients with stage I or II non-small cell lung cancer (NSCLC), surgical resection is considered the standard of care. Although surgery achieves long-term survival in many patients, a significant proportion experience locoregional or distant recurrence. Five-year survival rates after resection for stage I and II N...

journal_title：Seminars in radiation oncology

authors： Pisters KM

更新日期：2000-10-01 00:00:00

abstract：:Under the current World Health Organization (WHO) classification, gliomas can be divided into diffuse variants such as astrocytoma, oligodendroglioma, and mixed oligo-astrocytoma versus more discrete subtypes such as pilocytic astrocytoma and other less common entities. These tumors have been assigned histologic grade...

journal_title：Seminars in radiation oncology

authors： Fuller CE,Perry A

更新日期：2001-04-01 00:00:00

abstract：:Highly conformal fields have become achievable in routine clinical practice. The optimal shape of the resultant dose distributions depends on information that is not currently available. This missing information is the dose-volume response of the normal tissues at risk. These functions are now the subject of aggressiv...

journal_title：Seminars in radiation oncology

authors： Schultheiss TE

更新日期：2001-07-01 00:00:00

abstract：:Local recurrence after a definitive course of radiation therapy remains a significant clinical problem and represents a common pattern of failure for many solid tumors. The sensitivity of tumor cells to the cytotoxicity of ionizing radiation is thought to be one of the major determinants of local control for tumors in...

journal_title：Seminars in radiation oncology

authors： Jones HA,Hahn SM,Bernhard E,McKenna WG

更新日期：2001-10-01 00:00:00

abstract：:Within the past decade, focus on radiation to prevent restenosis has moved from a concept developed in the animal laboratory to a clinical treatment. The initial evaluation of coronary artery radiation therapy focused on changes in the function of the artery or lesion formation following overstretch balloon injury in ...

journal_title：Seminars in radiation oncology

authors： Crocker I,Robinson KA

更新日期：2002-01-01 00:00:00

abstract：:The authors discuss the results of 3 studies of their group reflecting the possible role of amifostine in simultaneous radiochemotherapy (RCT) of advanced head and neck cancer. In a controlled phase II trial (1995 through 1996), 39 patients were included in this pilot investigation. A control group (n = 14) received s...

journal_title：Seminars in radiation oncology

authors： Büntzel J,Glatzel M,Kuttner K,Weinaug R,Fröhlich D

更新日期：2002-01-01 00:00:00