Myeloid-derived suppressor cells in obesity-associated periodontal disease: A conceptual model.

Abstract:

:Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeth. Severe periodontitis is highly prevalent-affecting 10%-15% of adults-and carries several negative comorbidities, thus reducing quality of life. Although a clear relationship exists between severity of obesity and incidence of periodontal disease, the biologic mechanisms that support this link are incompletely understood. In this conceptual appraisal, a new "two-hit" model is presented to explain obesity-exacerbated periodontal bone loss. This proposed model recognizes a previously unappreciated aspect of myeloid-derived suppressor cell population expansion, differentiation, and activity that can participate directly in periodontal bone loss, providing new mechanistic and translational perspectives.

journal_name

Periodontol 2000

journal_title

Periodontology 2000

authors

Kwack KH,Maglaras V,Thiyagarajan R,Zhang L,Kirkwood KL

doi

10.1111/prd.12384

keywords:

["bone","inflammation","myeloid-derived suppressor cells","obesity","osteoclasts","periodontitis"]

subject

Has Abstract

pub_date

2021-10-01 00:00:00

pages

268-275

issue

1

eissn

0906-6713

issn

1600-0757

journal_volume

87

pub_type

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