Involvement of autophagy in diosgenin‑induced megakaryocyte differentiation in human erythroleukemia cells.

abstract：:Space travel exposes astronauts to a plethora of potentially detrimental conditions, such as cosmic radiation and microgravity. As both factors are hard to simulate on Earth, present knowledge remains limited. However, this knowledge is of vital importance, making space flight experiments a necessity for determining t...

journal_title：Molecular medicine reports

authors： Dieriks B,De Vos WH,Moreels M,Ghardi M,Hennekam R,Broers JL,Baatout S,van Oostveldt P

更新日期：2011-01-01 00:00:00

abstract：:The mechanisms by which thyroid stimulating hormone (TSH) regulates the expression and activity of sodium iodide symporter (NIS) through cAMP-PKA have been partially elucidated by many studies. However, the effects of the TSH-mediated PLC-IP3 signaling pathway on the expression of NIS and how intracellular iodinated c...

journal_title：Molecular medicine reports

authors： Huang H,Shi Y,Lin L,Li X,Li L,Lin X,Xu D

更新日期：2011-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix (ECM) molecules. ECM degradation is associated with tumor metastasis and angiogenesis. Therefore, the regulation of MMPs is of potential benefit in the treatment of various diseases, including cancer. A-kinase anchoring ...

journal_title：Molecular medicine reports

authors： Lee SW,Jung KH,Jeong CH,Seo JH,Yoon DK,Suh JK,Kim KW,Kim WJ

更新日期：2011-01-01 00:00:00

abstract：:Defects or deficiencies in red cell membrane skeletal proteins often undermine the integrity and stability of the plasma membrane, and consequently cause hereditary hemolytic anemias. Genetic and biochemical studies have revealed a complicated picture of the organization of the membrane skeleton, within which α-/β-spe...

journal_title：Molecular medicine reports

authors： Zhang DQ,Wang YP,Wang WH,Sui XM,Jiang JQ,Jiang XM,Xu ZS,Liu YG

更新日期：2011-07-01 00:00:00

abstract：:Van der Woude syndrome (VWS) is an autosomal dominant inherited disease characterized by lower lip pits, cleft lip and/or cleft palate. Missense, nonsense and frameshift mutations in IRF6 have been revealed to be responsible for VWS in European, Asian, North American and Brazilian populations. However, the mutations r...

journal_title：Molecular medicine reports

authors： Birkeland AC,Larrabee Y,Kent DT,Flores C,Su GH,Lee JH,Haddad J Jr

更新日期：2011-03-01 00:00:00

abstract：:It is recognized that catechin possesses beneficial properties for bone metabolism. We previously revealed that triiodothyronine (T₃)-activated p38 mitogen-activated protein (MAP) kinase, but not p44/p42 MAP kinase, is involved in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells. In the present study, we...

journal_title：Molecular medicine reports

authors： Kato K,Otsuka T,Adachi S,Matsushima-Nishiwaki R,Natsume H,Kozawa O,Tokuda H

更新日期：2011-03-01 00:00:00

abstract：:Gefitinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, has been clinically demonstrated to be effective in certain cancer cell types. In the present study, using the yeast Saccharomyces cerevisiae as a model, gefitinib-induced apoptotic cell death was demonstrated. Gefitinib i...

journal_title：Molecular medicine reports

authors： Wu J,Min R,Wu M,Chen W

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study was to evaluate the application of quantum dots (QDs) and the FITC labeling technique in Tca8113 cells, and to compare the fluorescence intensity and photostability of these techniques. First, using one-colour confocal microscopy, QDs and FITC were applied separately to tag HSP70 in Tca8113 strai...

journal_title：Molecular medicine reports

authors： Zhao JJ,Chen J,Wang ZP,Pan J,Huang YH

更新日期：2011-05-01 00:00:00

abstract：:Tumor protein p53 (TP53) is the best-known tumor suppressor gene and plays a crucial role in carcinogenesis. The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. Therefore, we investigated the effect...

journal_title：Molecular medicine reports

authors： Sonoyama T,Sakai A,Mita Y,Yasuda Y,Kawamoto H,Yagi T,Yoshioka M,Mimura T,Nakachi K,Ouchida M,Yamamoto K,Shimizu K

更新日期：2011-05-01 00:00:00

abstract：:Diallyl disulfide (DADS), a sulfur compound derived from garlic, has been shown to have protective effects against colon carcinogenesis in several studies performed in rodent models. However, its molecular mechanism of action remains unclear. This study was designed to confirm the anti-proliferative activity of DADS a...

journal_title：Molecular medicine reports

authors： Huang YS,Xie N,Su Q,Su J,Huang C,Liao QJ

更新日期：2011-05-01 00:00:00

abstract：:Galanin is a 29 amino acid neuropeptide that is widely distributed in the nervous system and acts by binding to three G protein-coupled receptors (GalR1, GalR2 and GalR3). In the literature, the presence of galanin has been reported in nerve fibers innervating the rat carotid body; however, direct evidence of the diff...

journal_title：Molecular medicine reports

authors： Porzionato A,Macchi V,Barzon L,Masi G,Belloni A,Parenti A,Palù G,De Caro R

更新日期：2010-01-01 00:00:00

abstract：:Nerve growth factor (NGF) as an autocrine or paracrine growth factor plays a critical role in the pathogenesis and progression of human pancreatic cancer. NGF is synthesized as a proform (proNGF) that, when cleaved, releases mature ligand (mNGF). proNGF and mNGF bind to high-affinity tyrosine kinase receptor A (TrkA) ...

journal_title：Molecular medicine reports

authors： Wang ZY,Ding Y,Miki T,Warita K,Matsumoto Y,Takeuchi Y,Wang SJ,Feng JG,Liu W,Wang YD,Wang XL,Wang YH,Liu Y,Shan BE

更新日期：2010-01-01 00:00:00

abstract：:In our previous study, we showed that basic fibroblast growth factor (bFGF) stimulates the synthesis of vascular endothelial growth factor (VEGF) via the activation of p44/p42 mitogen-activated protein (MAP) kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in osteoblast-like MC3T3-E1 cells...

journal_title：Molecular medicine reports

authors： Tokuda H,Adachi S,Matsushima-Nishiwaki R,Hanai Y,Takai S,Harada A,Kozawa O

更新日期：2010-01-01 00:00:00

abstract：:Sphingosine-1 phosphate receptor (S1PR) has come to the fore as a mediator of extracellular signaling through its interaction with G-protein-coupled receptors, which results in the induction of peripheral T-cell depletion. The mechanisms involved in renal ischemia-reperfusion (I/R) injury are complex, but appear to in...

journal_title：Molecular medicine reports

authors： Matsuyama M,Funao K,Kuratsukuri K,Tanaka T,Kawahito Y,Sano H,Chargui J,Touraine JL,Yoshimura N,Yoshimura R

更新日期：2010-03-01 00:00:00

abstract：:The existence of possible threshold dose levels of genotoxic carcinogens for carcinogenesis is of particular interest for human risk assessment. Recently, no observed effect levels (NOELs) for various hepatocarcinogens have been reported. However, reports on threshold levels for lung carcinogenesis have hitherto been ...

journal_title：Molecular medicine reports

authors： Suzuki S,Yokohira M,Hashimoto N,Saoo K,Matsuda Y,Yamakawa K,Nakano Y,Kuno T,Imaida K

更新日期：2010-03-01 00:00:00

abstract：:In ketone body metabolism, hepatocyte-specific silencing of the succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene appears to be physiologically important to avoid a futile cycle in the liver, whereas the SCOT gene is expressed in extrahepatic tissues. It is not possible to explain hepatocyte-specific silencing by ci...

journal_title：Molecular medicine reports

authors： Fukao T,Zhang G,Matsuo N,Kondo N

更新日期：2010-03-01 00:00:00

abstract：:Cirsium japonicum is a wild perennial herb that has been used as an anti-hemorrhagic, anti-hypertensive and uretic agent in traditional Chinese medicine. Recently, it was reported that C. japonicum inhibits the growth of implanted cancer cells. However, the molecular mechanisms underlying the anti-cancer properties of...

journal_title：Molecular medicine reports

authors： Kim DY,Kang SH,Ghil SH

更新日期：2010-05-01 00:00:00

abstract：:Nasal polyposis (NP) is a chronic inflammatory disease of the nasal mucosa characterized by the infiltration of inflammatory cells, mainly eosinophils. Although nasal polyposis occurs in 4% of the population, its physiopathology remains unclear. The aim of this study was to identify and characterize differentially exp...

journal_title：Molecular medicine reports

authors： Babeto E,De Freitas Calmon M,Scarin Provazzi PJ,Colombo J,Cordeiro JA,Bonilha JL,Fernandes AM,Rahal P

更新日期：2010-05-01 00:00:00

abstract：:Accumulating evidence suggests that dendritic cells (DCs) play a crucial role in the generation and progression of atherosclerosis (ATS), a lipid-related immuno-inflammatory disease. DCs have the ability to process and present antigens (mainly oxidized low-density lipoproteins, heat shock proteins and fragments of nec...

journal_title：Molecular medicine reports

authors： Puddu P,Puddu GM,Cravero E,Muscari S,Muscari A

更新日期：2010-07-01 00:00:00

abstract：:Proteasome inhibitors and histone deacetylase (HDAC) inhibitors are two promising groups of anti-cancer agents. In this study, we examined the apoptotic effects of the proteasome inhibitor bortezomib and HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) in human cervical carcinoma HeLa cells. Compared to treatment...

journal_title：Molecular medicine reports

authors： Jiang Y,Wang Y,Su Z,Yang L,Guo W,Liu W,Zuo J

更新日期：2010-07-01 00:00:00

abstract：:Two abietane and one labdane type diterpenoids were isolated from the methanol extracts of Torreya nucifera pulp and investigated for their ability to inhibit the growth of human cancer cells. Among the three compounds, the labdane compound kayadiol was found to have the most effective inhibitory effect against a wide...

journal_title：Molecular medicine reports

authors： Chen SP,Dong M,Kita K,Shi QW,Cong B,Guo WZ,Sugaya S,Sugita K,Suzuki N

更新日期：2010-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are collectively capable of cleaving virtually all extracellular matrix (ECM) substrates and play an important role in diverse physiological and pathological processes. The activity of MMPs is controlled at multiple levels, and the tra...

journal_title：Molecular medicine reports

authors： Munhoz FB,Godoy-Santos AL,Santos MC

更新日期：2010-09-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of Beclin 1 knockdown on spontaneous and vitamin K3 (VK3)-regulated autophagy, survival and apoptosis in human hepatocarcinoma SMMC-7721 cells, and to explore the potential mechanisms underlying the action of Beclin 1 knockdown in the processes of autophagy a...

journal_title：Molecular medicine reports

authors： Yang C,Han LO

更新日期：2010-09-01 00:00:00

abstract：:The demographic features and prognostic profiles of breast cancer patients with nipple discharge (ND) have not been well elucidated in previous studies. We therefore performed a retrospective study of female unilateral breast cancer patients that underwent surgery. According to the initial symptoms at diagnosis, a tot...

journal_title：Molecular medicine reports

authors： Yin WJ,Di GH,Liu GY,Wu J,Lu JS,Han QX,Shen ZZ,Shao ZM

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to investigate whether the JAK-STAT pathway participates in the processes of proliferation and differentiation induced by connective tissue growth factor (CTGF) in human hypertrophic scar fibroblasts (hHSF). hHSF were grown as primary cultures, then treated with or without CTGF. Western blott...

journal_title：Molecular medicine reports

authors： Tao L,Liu J,Li Z,Dai X,Li S

更新日期：2010-11-01 00:00:00

abstract：:Let-7g miRNAs, short non-coding RNAs approximately 21 nucleotides long, repress protein translation by binding to the 3'UTR of target mRNAs. Aberrant expression of let-7g is associated with the poor prognosis of lung cancer patients. Compared to normal lung cells, let-7g expression is absent in non-small cell lung can...

journal_title：Molecular medicine reports

authors： Park S,Minai-Tehrani A,Xu CX,Chang SH,Woo MA,Noh MS,Lee ES,Lim HT,An GH,Lee KH,Sung HJ,Beck GR,Cho MH

更新日期：2010-11-01 00:00:00

abstract：:In the present study, we investigated the effect of the taxol resistance gene 1 (TXR1) on taxol resistance in gastric cancer (GC). Immunohistochemistry was performed in order to assess the expression pattern of TXR1 in paraffin-embedded specimens of 107 GC patients who underwent radical D2 gastrectomy with long-term f...

journal_title：Molecular medicine reports

authors： Bai ZG,Qu X,Han W,Ma XM,Zhao XM,Zhang ZT

更新日期：2010-11-01 00:00:00

abstract：:Antitumor activities have been reported for the aromatics Tonalide (6-acetyl-1,1,2,4,4,7-hexamethyl-tetrahydronaphthalene, AHTN) and Pearlide (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-γ-2-benzopyran, HHCB), which are contained in detergents. In this study, their carcinostatic activities in Ehrlich ascit...

journal_title：Molecular medicine reports

authors： Asada R,Kageyama K,Tanaka H,Mimura H,Miwa N

更新日期：2009-01-01 00:00:00

abstract：:The statins, a family of cholesterol-lowering drugs, are known to block the formation of isoprenoids. They thus affect the small GTPase Rho, which requires attachment to cell membranes for proper signaling activity. Chimaerins are GTPase-activating proteins (GAPs) that accelerate GTP hydrolysis from Rac, another GTPas...

journal_title：Molecular medicine reports

authors： Menna PL,Parera RL,Cardama GA,Alonso DF,Gomez DE,Farina HG

更新日期：2009-01-01 00:00:00

abstract：:The metabolism of arachidonic acid by either cyclooxygenase or lipoxygenase is believed to play an important role in carcinogenesis. Leukotriene (LT) D4 is a pro-inflammatory mediator derived from arachidonic acid through various enzymatic steps, and 5-lipoxygenase is an important factor in generating LTD4. We investi...

journal_title：Molecular medicine reports

authors： Matsuyama M,Funao K,Kawahito Y,Sano H,Chargui J,Touraine JL,Nakatani T,Yoshimura R

更新日期：2009-03-01 00:00:00