Abstract：
:Low-molecular-weight thiols play a central role in preventing oxidative damage caused by reactive oxygen species to maintain a reductive intracellular environment in bacteria. Therefore, targeting thiol-redox homeostasis is considered a promising antimicrobial strategy. Here, we synthesize histidine-stabilized gold nanoclusters (Au NCs), in which the histidine ligand has a weak affinity for gold, thus constructing an effective thiol scavenger by employing metal-thiol depletion chemicals. Au NCs exert excellent antimicrobial effects by consuming thiols and simultaneously causing the accumulation of reactive oxygen species in bacteria, resulting in severe oxidative stress. In a mouse skin wound model infected with ampicillin-resistant Escherichia coli pHSP70-EGFP, a low dose of Au NCs exerts a strong therapeutic effect on bacterial clearance and wound healing, indicating the effectiveness of this antimicrobial strategy for clinical application.
journal_name
Talantajournal_title
Talantaauthors
Meng J,Gao Y,Li W,Wang J,Chen Xdoi
10.1016/j.talanta.2021.122618keywords:
["Au NCs","Bacterial multidrug resistance","Histidine","Metal-thiol depletion chemicals","Thiol-redox homeostasis"]subject
Has Abstractpub_date
2021-11-01 00:00:00pages
122618eissn
0039-9140issn
1873-3573pii
S0039-9140(21)00539-7journal_volume
234pub_type
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