Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody.

abstract：:The sustained release nature of ofloxacin microspheres--to eradicate bacterial biofilm associated with chronic infections from sensitive strains of bacteria--was determined both in vitro and in vivo. Ofloxacin microspheres were prepared by emulsion solvent evaporation procedure using poly(glycolic acid-co-dl-lactic ac...

journal_title：Drug delivery

authors： Abazinge M,Jackson T,Yang Q,Owusu-Ababio G

更新日期：2000-04-01 00:00:00

abstract：:We have shown that the epidural (EPI) delivery of morphine encapsulated in multivesicular liposomes (DepoFoam drug delivery system) produces a sustained clearance of morphine and a prolonged analgesia. We have sought to subsequently determine the likelihood of deleterious effects on local tissue of repetitive epidural...

journal_title：Drug delivery

authors： Yaksh TL,Provencher JC,Rathbun ML,Myers RR,Powell H,Richter P,Kohn FR

更新日期：2000-01-01 00:00:00

abstract：:High-density lipoprotein (HDL) is a reliable predictor for susceptibility to cardiovascular disease. Since apolipoprotein A-I (apoA-I) is the major protein of HDL, it is worthwhile to evaluate the potential of this protein to reduce the lipid burden of lesions observed in the clinic. While a large body of data emanate...

journal_title：Drug delivery

authors： Dass CR

更新日期：2000-07-01 00:00:00

abstract：:Despite the rapid development in medicinal and pharmaceutical technology, the targeting of drugs to phagocytic cells in macrophage-related diseases still remains a major unsolved problem. By using the mannosyl-fucosyl receptors on macrophages, attempts were made to target antileishmanial drugs encapsulated in mannosyl...

journal_title：Drug delivery

authors： Sinha J,Mukhopadhyay S,Das N,Basu MK

更新日期：2000-10-01 00:00:00

abstract：:Conventional and sterically stabilized liposomes derived from phosphatidylcholine or the antitumor agents, hexadecylphosphocholine and octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate, as bilayer forming constituents, containing bleomycin, were developed and tested. Liposomal encapsulation of bleomycin enhanced st...

journal_title：Drug delivery

authors： Arndt D,Zeisig R,Bechtel D,Fichtner I

更新日期：2001-01-01 00:00:00

abstract：:The aim of our work was to probe the mechanisms associated with induced matrix stiffening via textural analysis as a consequence of in situ electrolyte interactions within hydroxypropyl-methylcellulose (HPMC) and polyethylene oxide (PEO) matrices in relation to their role in controlling the release of highly soluble d...

journal_title：Drug delivery

authors： Pillay V,Fassihi R

更新日期：2001-04-01 00:00:00

abstract：:Many studies have shown that topical buccal therapy with steroid anti-inflammatory drugs is useful in controlling ulcerative and inflammatory mucosal diseases. This local treatment is based on the concept that a high activity of steroids can be produced at the site of administration and, at the same time, the degree o...

journal_title：Drug delivery

authors： Ceschel GC,Maffei P,Lombardi Borgia S,Ronchi C

更新日期：2001-07-01 00:00:00

abstract：:The passage of a drug through the skin is directly proportional to the concentration of the drug in the donor phase and to the permeability coefficient constant Kp. Kp is determined essentially by two factors: the dissolution of the drug in the stratum corneum (measured by the partition coefficient P) and the diffusio...

journal_title：Drug delivery

authors： Ceschel GC,Maffei P,Lombardi Borgia S

更新日期：2002-01-01 00:00:00

abstract：:Spherical polymeric microparticles have been prepared by a reverse phase suspension polymerization technique. The starting polymer was alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) was crosslinked in the presence of N,N'-dimethy...

journal_title：Drug delivery

authors： Pitarresi G,Pierro P,Giammona G,Muzzalupo R,Trombino S,Picci N

更新日期：2002-04-01 00:00:00

abstract：:The objective of our study was to compare the in vitro release kinetics of a sustained-release injectable microsphere formulation of the polypeptide drug, calcitonin (CT), to optimize the characteristics of drug release from poly-(lactide-co-glycolide) (PLGA) copolymer biodegradable microspheres. A modified solvent ev...

journal_title：Drug delivery

authors： Prabhu S,Sullivan JL,Betageri GV

更新日期：2002-07-01 00:00:00

abstract：:The aim of the present study is to develop colon-targeted drug delivery systems for ornidazole using guar gum as a carrier. The core formulation containing ornidazole was directly compressed. Compression-coated tablets of ornidazole containing various proportions of guar gum in the coat were prepared. All the formulat...

journal_title：Drug delivery

authors： Krishnaiah YS,Muzib YI,Rao GS,Bhaskar P,Satyanarayana V

更新日期：2003-04-01 00:00:00

abstract：:Transdermal drug delivery system of diltiazem hydrochloride was developed to obtain a prolonged controlled drug delivery. Both the matrix diffusion controlled (MDC) and membrane permeation controlled (MPC) systems were developed. The matrix diffusion controlled systems used various combinations of hydrophilic and lipo...

journal_title：Drug delivery

authors： Jain SK,Chourasia MK,Sabitha M,Jain R,Jain AK,Ashawat M,Jha AK

更新日期：2003-07-01 00:00:00

abstract：:Nitrogen mustard agents are widely used for the clinical treatment of cancers. A nitrogen mustard (N-mustard) agent was synthesized utilizing nicotinic acid as the carrier of the alkylating substituent (-OCH2CH2N(CH2CH2Cl)2) that forms an ester group (R-C(O)-OR) on a heterocyclic ring. The N-mustard agent is a solid a...

journal_title：Drug delivery

authors： Bartzatt RL

更新日期：2004-01-01 00:00:00

abstract：:The development of mucoadhesive formulations of buprenorphine for intended sublingual usage in the treatment of drug addiction is described. The formulations include mucoadhesive polymer films, with or without plasticizers, and mucoadhesive polymer tablets, with or without excipients that enhance drug release and/or i...

journal_title：Drug delivery

authors： Das NG,Das SK

更新日期：2004-03-01 00:00:00

abstract：:The objective of our study was to incorporate and evaluate Silymarin, a chemically defined natural hepatoprotective agent, in lipid microstructured systems. Various constituents of lipid microspheres--namely, internal oily core; surfactant such as soyabean lecithin; and cosurfactants such as span 20, tween 20, tween 8...

journal_title：Drug delivery

authors： Abrol S,Trehan A,Katare OP

更新日期：2004-05-01 00:00:00

abstract：:A delivery system consisting of the lipophilic fluorescent dye coumarin-6 embedded into polymer nanoparticles in a suppository base was formulated. Particle diameters of 400-1100 nm were produced by a salting-out method and measured by laser diffraction. Nanoparticles reach the systemic circulation via fenestrated cap...

journal_title：Drug delivery

authors： Eley JG,Pujari VD,McLane J

更新日期：2004-07-01 00:00:00

abstract：:Uptake of novel inherently fluorescent microspheres composed of a luminescent polyanhydride, poly[p-(carboxyethylformamido)-benzoic anhydride] (PCEFB), and poly(lactide-co-glycolide) (PLGA) (2:1, weight ratio) by the gastrointestinal tract was evaluated by fluorescent microscopy. Oral efficiency of the incorporated in...

journal_title：Drug delivery

authors： Li Y,Jiang HL,Jin JF,Zhu KJ

更新日期：2004-11-01 00:00:00

abstract：:Liposomal nerve growth factor (NGF) was used for the treatment of focal cerebral ischemia in a rat model. Positive charge inducing agents of sphingosine (SP) and stearylamine (S) were formulated in the liposomal NGF. Dose-response of intraventricular injection of liposomal NGF showed significant reduction in infarct v...

journal_title：Drug delivery

authors： Luk YO,Chen WY,Wong WJ,Hu HH,Hsu LC,Chern CM,Huang KJ,Law SL

更新日期：2004-09-01 00:00:00

abstract：:Polymeric micelles based on polyvinyl alcohol substituted with oleic acid were used as vehicles for progesterone and folic acid. The ability of this amphiphilic polymer to entrap lipophilic drugs and to generate stable micelles in aqueous neutral medium makes it a good candidate for drug delivery. The release of the l...

journal_title：Drug delivery

authors： Luppi B,Bigucci F,Cerchiara T,Andrisano V,Pucci V,Mandrioli R,Zecchi V

更新日期：2005-01-01 00:00:00

abstract：:Targeting of mechanochemically activated doxorubicin (MA DOXO) nanoparticles, conventional doxorubicin, and electromagnetic irradiation (EMI) at A-549 lung carcinoma cells in vitro was investigated. Conventional DOXO was micronized using an input energy of 20 W/g for 5 min resulting in positively charged MA DOXO parti...

journal_title：Drug delivery

authors： Orel VE,Kudryavets YI,Satz S,Bezdenezhnih NA,Danko ML,Khranovskaya NN,Romanov AV,Dzyatkovskaya NN,Burlaka AP

更新日期：2005-05-01 00:00:00

abstract：:The aim of this research is the preparation of acryloylated bovine serum albumin microspheres and the evaluation of their employment in drug delivery. The influence of preparation parameters on albumin microspheres and the chemicophysical properties of loaded drugs were investigated. In particular, we focused our atte...

journal_title：Drug delivery

authors： Iemma F,Spizzirri UG,Puoci F,Muzzalupo R,Trombino S,Picci N

更新日期：2005-07-01 00:00:00

abstract：:Bovine serum albumin nanospheres carrying cyclodextrin complexes for the delivery of progesterone were produced. Inclusion complexes composed of progesterone and hydroxypropyl-beta-cyclodextrin or dimethyl-beta-cyclodextrin were prepared by spray-drying or freeze-drying methods. Prog alone and its inclusion complexes ...

journal_title：Drug delivery

authors： Luppi B,Cerchiara T,Bigucci F,Caponio D,Zecchi V

更新日期：2005-09-01 00:00:00

abstract：:The aim of our present work was to establish the effect of the osmolality of the hypotonic buffer on the encapsulated amount and the in vitro properties of Amikacin-loaded erythrocytes. Amikacin was encapsulated in rat erythrocytes using a hypotonic dialysis method with hypotonic buffers of different osmolalities with...

journal_title：Drug delivery

authors： Millán CG,Castañeda AZ,López FG,Marinero ML,Lanao JM,Arévalo M

更新日期：2005-11-01 00:00:00

abstract：:The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release properties. Samples were characterized by measuring the swelling behavior and in vitro release...

journal_title：Drug delivery

authors： Stanojević M,Krusić MK,Filipović J,Parojcić J,Stupar M

更新日期：2006-01-01 00:00:00

abstract：:Lipospheres of carbamazepine were prepared by melt dispersion technique using Precifac ATO 5 in the various drug-lipid ratios. The resulting free-flowing lipospheres were evaluated with respect to surface morphology, particle size distribution, encapsulation efficiency, and in vitro release behavior. The effect of dru...

journal_title：Drug delivery

authors： Barakat NS,Yassin AE

更新日期：2006-03-01 00:00:00

abstract：:A noval cellulose acetate/chitosan multimicrospheres (CACM) was prepared by the method of w/o/w emulsion. The concentration of cellulose acetate (CA) and the ratio of CA/chitosan (CS) had influence on the CACM size, and appearance. Ranitidine hydrochloride loading, and releasing efficiency in vitro were investigated. ...

journal_title：Drug delivery

authors： Zhou HY,Chen XG,Liu CS,Meng XH,Liu CG,He J,Yu le J

更新日期：2006-07-01 00:00:00

abstract：:Recent studies have implicated the cytokine tumor necrosis factor-alpha (TNF-alpha) in the inflammation associated with Crohn's disease (CD). Thalidomide has been shown to decrease this inflammation by the suppression of TNF-alpha secretion. However, side effects associated with thalidomide have precluded its widespre...

journal_title：Drug delivery

authors： Metz T,Haque T,Chen H,Prakash S,Amre D,Das SK

更新日期：2006-09-01 00:00:00

abstract：:Pegylation, generally described as the molecular attachment of polyethylene glycols (PEGs) with different molecular weights to active drug molecules or surface treatment of drug-bearing particles with PEGs, is one of the most promising and extensively studied strategies with the goal of improving the pharmacokinetic b...

journal_title：Drug delivery

authors： Hamidi M,Azadi A,Rafiei P

更新日期：2006-11-01 00:00:00

abstract：:Chitosan phthalate polymer was synthesized and its microspheres were prepared by emulsion phase separation technique. The characterization of microspheres was determined by means of FTIR spectroscopy, electron microscopy, particle size, and zeta potential. The insulin was loaded to the microspheres by passive absorpti...

journal_title：Drug delivery

authors： Ubaidulla U,Sultana Y,Ahmed FJ,Khar RK,Panda AK

更新日期：2007-01-01 00:00:00

abstract：:The purpose of our research was to evaluate in vitro therapeutic efficacy of doxorubicin (DXR)-loaded immunoliposomes with Fab' fragments of the anti-CD74 antibody LL1 attached to the surface. LL1 is well suited for targeting purposes because it is internalized very fast by B-lymphoma cells. However, at in vivo applic...

journal_title：Drug delivery

authors： Lundberg BB,Griffiths G,Hansen HJ

更新日期：2007-03-01 00:00:00