Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.

abstract：:Arf6 and its effector AMAP1 are overexpressed in malignant breast cancer cells, and are involved in their invasion and metastasis. We recently revealed that GEP100, a guanine nucleotide exchanging factor, is responsible for the activation of Arf6 which induces invasion and metastasis. GEP100 associated directly with l...

journal_title：Cell adhesion & migration

authors： Sabe H,Hashimoto S,Morishige M,Hashimoto A,Ogawa E

更新日期：2008-04-01 00:00:00

abstract：:Cell migration is an integrated process that involves cell adhesion, protrusion and contraction. We recently used CAS (Crk-associated substrate, 130CAS)-deficient mouse embryo fibroblasts (MEFs) to examined contribution made to v-Crk to that process via its interaction with Rac1. v-Crk, the oncogene product of avian s...

journal_title：Cell adhesion & migration

authors： Yeo MG,Song WK

更新日期：2008-07-01 00:00:00

abstract：:Members of the integrin family of cell adhesion receptors are pivotal to the formation of complex tissues and organs in animals. They mediate cell adhesion by interacting with the extracellular matrix and by binding to intracellular linker proteins that connect to the cytoskeleton. We have recently identified a new an...

journal_title：Cell adhesion & migration

authors： Löer B,Hoch M

更新日期：2008-07-01 00:00:00

abstract：:Mechanical forces play an important role in the organization, growth and function of tissues. Dynamic extracellular environment affects cellular behavior modifying their orientation and their cytoskeleton. In this work, human fibroblasts have been subjected for three hours to increasing substrate deformations (1-25%) ...

journal_title：Cell adhesion & migration

authors： Boccafoschi F,Bosetti M,Gatti S,Cannas M

更新日期：2007-07-01 00:00:00

abstract：:Canonical WNT signals play an important role in hair follicle development. In addition to being crucial for epidermal appendage initiation, they control the interfollicular spacing pattern and contribute to the spatial orientation and largely parallel alignment of hair follicles. However, owing to the complexity of ca...

journal_title：Cell adhesion & migration

authors： Schlake T,Sick S

更新日期：2007-07-01 00:00:00

abstract：:The migration of neuronal growth cones, driving axon extension, is a fascinating process which has been subject of intense investigation over several decades. Many of the key underlying molecules, in particular adhesion proteins at the cell membrane which allow for target recognition and binding, and cytoskeleton fila...

journal_title：Cell adhesion & migration

authors： Thoumine O

更新日期：2008-10-01 00:00:00

abstract：:The cannabinoid signaling system is located during brain development in a position concordant with playing a modulatory function in the regulation of neuronal and glial cell proliferation and migration, survival of neural progenitors, axonal elongation and synaptogenesis and differentiation of oligodendrocytes and for...

journal_title：Cell adhesion & migration

authors： Gómez M,Hernández M,Fernández-Ruiz J

更新日期：2008-10-01 00:00:00

abstract：:Huntington disease (HD) is caused by a polyglutamine expansion in the protein huntingtin (Htt). Several studies suggest that Htt and huntingtin associated protein 1 (HAP1) participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. Understanding the function of HAP1 and its r...

journal_title：Cell adhesion & migration

authors： Wu LL,Zhou XF

更新日期：2009-01-01 00:00:00

abstract：:Brain tumors exhibit marked and aberrant blood vessel formation indicating angiogenic endothelial cells as a potential target for brain tumor treatment. The brain tumor blood vessels are used for nutrient delivery, and possibly for cancer cell migration. The process of angiogenesis is complex and involves multiple pla...

journal_title：Cell adhesion & migration

authors： Würdinger T,Tannous BA

更新日期：2009-04-01 00:00:00

abstract：:Chemokines are a class of inflammatory mediators which main function is to direct leukocyte migration through the binding to G protein-coupled receptors (GPCRs). In addition to these functional, signal-transducing chemokine receptors other types of receptors belonging to the chemokine GPCR family were identified. They...

journal_title：Cell adhesion & migration

authors： Borroni EM,Bonecchi R

更新日期：2009-04-01 00:00:00

abstract：:Constitutive overexpression of N-cadherin in mouse embryonic stem cells led to marked changes in the phenotype and adhesion properties of these cells. The changes included the formation of smaller embryonic bodies, elevated mRNA and total protein levels of N-cadherin, and increased amounts of p120 catenin and connexin...

journal_title：Cell adhesion & migration

authors： Karabekian Z,Gillum ND,Wong EW,Sarvazyan N

更新日期：2009-07-01 00:00:00

abstract：:Focal adhesions (FA) are bidirectional mechanical biosensors that allow cells to integrate intracellular and extracellular cues. Their function is tightly regulated by changes in molecular composition and also by variation in the spatio-temporal dynamics of FA components within this structure. A closely regulated turn...

journal_title：Cell adhesion & migration

authors： Goetz JG

更新日期：2009-04-01 00:00:00

abstract：:DOCK180 is an atypical guanine nucleotide exchange factor of Rac1 identified originally as one of the two major proteins bound to the SH3 domain of the Crk adaptor protein. DOCK180 induces tyrosine phosphorylation of p130(Cas), and recruits the Crk-p130(Cas) complex to focal adhesions. Recently, we searched for DOCK18...

journal_title：Cell adhesion & migration

authors： Kiyokawa E,Matsuda M

更新日期：2009-07-01 00:00:00

abstract：:Matrix metalloproteases (MMPs) are key regulatory molecules in the formation, remodeling and degradation of extracellular matrix (ECM) components in both physiological and pathological processes in many tissues. In skeletal muscle, MMPs play an important role in the homeostasis and maintenance of myofiber functional i...

journal_title：Cell adhesion & migration

authors： Chen X,Li Y

更新日期：2009-10-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that acts as a primary regulator of focal adhesion signaling to regulate cell proliferation, survival and migration. While FAK is known to directly influence many fundamental adhesion and growth factor signaling pathways important in cancer and FAK is overex...

journal_title：Cell adhesion & migration

authors： Provenzano PP,Keely PJ

更新日期：2009-10-01 00:00:00

abstract：:Cell adhesion, migration, proliferation and differentiation are tightly linked and coordinated cellular processes. Cell adhesion dependent gene expression is believed to contribute to such coordination. Focal adhesion kinase (FAK) and its related protein, PYK2 (proline rich tyrosine kinase 2), are a major family of ce...

journal_title：Cell adhesion & migration

authors： Mei L,Xiong WC

更新日期：2010-01-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) can be directed to differentiate into a number of endoderm cell types, however mature functional cells have yet to be produced in vitro. This suggests that there may be important factors that have yet to be described, which may be essential for the proper derivation of these cells. O...

journal_title：Cell adhesion & migration

authors： Wong JC,Gao SY,Lees JG,Best MB,Wang R,Tuch BE

更新日期：2010-01-01 00:00:00

abstract：:Cellular division is an ordered, tightly regulated process involving multiple checkpoints that assess extracellular growth signals, cell size and DNA integrity. Progression throughout the cell cycle is based on the activation of different CDK-cyclin complexes that prevent cells from entering into a new phase until tha...

journal_title：Cell adhesion & migration

authors： Eymin B,Gazzeri S

更新日期：2010-01-01 00:00:00

abstract：:The transmembrane (TM) domains of receptor tyrosine kinases (RTKs) play an active role in signaling. They contribute to the stability of full-length receptor dimers and to maintaining a signaling-competent dimeric receptor conformation. In an exciting new development, two structures of RTK TM domains have been solved,...

journal_title：Cell adhesion & migration

authors： Li E,Hristova K

更新日期：2010-04-01 00:00:00

abstract：:Systemic delivery of multipotent mesenchymal stem cells (MSC) may be of benefit in the treatment of neurological diseases, including multiple sclerosis (MS). Certainly, animal studies have demonstrated functional benefits following MSC transplantation, although the mechanisms by which MSCs migrate to lesions and stimu...

journal_title：Cell adhesion & migration

authors： Rice CM,Scolding NJ

更新日期：2010-04-01 00:00:00

abstract：:Cell invasion and metastasis mark the most lethal phase of cancer, but little is known about the key molecular events that initiate this crucial turning point. Low oxygen, or hypoxia, is thought to be one trigger for metastasis. Hypoxic conditions within the tumor mass are thought to activate signaling pathways that s...

journal_title：Cell adhesion & migration

authors： Djagaeva I,Doronkin S

更新日期：2010-07-01 00:00:00

abstract：:Cardiac neural crest cells originate as part of the postotic caudal rhombencephalic neural crest stream. Ectomesenchymal cells in this stream migrate to the circumpharyngeal ridge and then into the caudal pharyngeal arches where they condense to form first a sheath and then the smooth muscle tunics of the persisting p...

journal_title：Cell adhesion & migration

authors： Kirby ML,Hutson MR

更新日期：2010-10-01 00:00:00

abstract：:CD43/sialophorin/leukosialin, a common leukocyte antigen, is known as an inhibitor for cell adhesion. The ectodomain of CD43 is considered as a molecular barrier for cell adhesion, while the cytoplasmic domain has a binding site for Ezrin/Radixin/Moesin (ERM). We found expression of CD43 induced cell rounding, inhibit...

journal_title：Cell adhesion & migration

authors： Yamane J,Ohnishi H,Sasaki H,Narimatsu H,Ohgushi H,Tachibana K

更新日期：2011-03-01 00:00:00

abstract：:N-cadherin is a homophilic cell adhesion molecule that plays important roles in many aspects of neuronal development. In order to better understand the function of N-cadherin mediated cell-cell contact in activity-dependent dendrite development, we generated a number of new tools. EC1, consisting of the first extracel...

journal_title：Cell adhesion & migration

authors： Yu X

更新日期：2011-05-01 00:00:00

abstract：:The significance of the widespread downregulation of Rap1GAP in human tumors is unknown. In previous studies we demonstrated that silencing Rap1GAP expression in human colon cancer cells resulted in sustained increases in Rap activity, enhanced spreading on collagen and the weakening of cell-cell contacts. The latter ...

journal_title：Cell adhesion & migration

authors： Vuchak LA,Tsygankova OM,Meinkoth JL

更新日期：2011-07-01 00:00:00

abstract：:Research into conditions that improve axon regeneration has the potential to open a new door for treatment of brain injury caused by stroke and neurodegenerative diseases of aging, such as Alzheimer, by harnessing intrinsic neuronal ability to reorganize itself. Elucidating the molecular mechanisms of axon regeneratio...

journal_title：Cell adhesion & migration

authors： Chiu H,Alqadah A,Chuang CF,Chang C

更新日期：2011-09-01 00:00:00

abstract：:X-ray irradiation influences metastatic properties of tumor cells and, moreover, metastasis and cellular motility can be modified by members of the Eph receptor/ephrin family of receptor tyrosine kinases. We hypothesized that irradiation-induced changes in cellular properties relevant for metastasis in melanoma cells ...

journal_title：Cell adhesion & migration

authors： Mosch B,Pietzsch D,Pietzsch J

更新日期：2012-03-01 00:00:00

abstract：:Recently, we monitored green fluorescent protein (GFP)-expressing monocytes after injection at the entorhinal cortex lesion (ECL) site in mice. We followed their migration out of the central nervous system (CNS) along olfactory nerve fibers penetrating the lamina cribrosa, within the nasal mucosa, and their subsequent...

journal_title：Cell adhesion & migration

authors： Kaminski M,Bechmann I,Kiwit J,Glumm J

更新日期：2012-05-01 00:00:00

abstract：:Integrins are a family of α/β heterodimeric adhesion metalloprotein receptors and their functions are highly dependent on and regulated by different divalent cations. Recently advanced studies have revolutionized our perception of integrin metal ion-binding sites and their specific functions. Ligand binding to integri...

journal_title：Cell adhesion & migration

authors： Zhang K,Chen J

更新日期：2012-01-01 00:00:00

abstract：:Integrin receptors play important roles in cell adhesion and tumor metastasis. The coupling of mechanical sensing and biochemical ligation is known to collectively regulate the activation of integrin receptors. Recently, oligomerization of activated integrins has been considered as the primordial signature of cytoskel...

journal_title：Cell adhesion & migration

authors： Yu CH,Luo W,Sheetz MP

更新日期：2012-05-01 00:00:00