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Synthesis and antitumor activity of tropolone derivatives. 5.

Abstract：

:As part of a study on the structure-activity relationship of antitumor-active tropolone derivatives, a series of bistropone analogues, related to potently active bistropolone 1a, were synthesized and tested for their antitumor activity in in vitro (KB cell) and in vivo (leukemia P388 in mice) systems. The methoxytropones 3 and 5, hydroxytropothione 10, and (N-methylamino)tropones 12 and 13 were inactive in both systems. Methoxytropone 6 exhibited weak activity, whose potency was equal to that of monotropolone 2a.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Yamato M,Hashigaki K,Sakai J,Takeuchi Y,Tsukagoshi S,Tashiro T,Tsuruo T

doi

10.1021/jm00390a022

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

1245-8

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

30

pub_type

杂志文章

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