Abstract:
:Several subtypes of T cells are located in a tumor environment, each of which supplies their energy using different metabolic mechanisms. Since the cancer cells require high levels of glucose, the conditions of food poverty in the tumor environment can cause inactivation of immune cells, especially the T-effector cells, due to the need for glucose in the early stages of these cells activity. Different signaling pathways, such as PI3K-AKt-mTOR, MAPK, HIF-1α, etc., are activated or inactivated by the amount and type of energy source or oxygen levels that determine the fate of T cells in a cancerous environment. This review describes the metabolites in the tumor environment and their effects on the function of T cells. It also explains the signaling pathway of T cells in the tumor and normal conditions, due to the level of access to available metabolites and subtypes of T cells in the tumor environment.
journal_name
Curr Cancer Drug Targetsjournal_title
Current cancer drug targetsauthors
Iranparast S,Tayebi S,Ahmadpour F,Yousefi Bdoi
10.2174/1568009620666200720010647subject
Has Abstractpub_date
2020-01-01 00:00:00pages
741-756issue
10eissn
1568-0096issn
1873-5576pii
CCDT-EPUB-108302journal_volume
20pub_type
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journal_title:Current cancer drug targets
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