Abstract:
:Since the 1st discovery of transcriptional enhancers in 1981, their textbook definition has remained largely unchanged in the past 37 years. With the emergence of high-throughput assays and genome editing, which are switching the paradigm from bottom-up discovery and testing of individual enhancers to top-down profiling of enhancer activities genome-wide, it has become increasingly evidenced that this classical definition has left substantial gray areas in different aspects. Here we survey a representative set of recent research articles and report the definitions of enhancers they have adopted. The results reveal that a wide spectrum of definitions is used usually without the definition stated explicitly, which could lead to difficulties in data interpretation and downstream analyses. Based on these findings, we discuss the practical implications and suggestions for future studies.
journal_name
Brief Bioinformjournal_title
Briefings in bioinformaticsauthors
Ho EY,Cao Q,Gu M,Chan RW,Wu Q,Gerstein M,Yip KYdoi
10.1093/bib/bbz030subject
Has Abstractpub_date
2020-05-21 00:00:00pages
836-850issue
3eissn
1467-5463issn
1477-4054pii
5381766journal_volume
21pub_type
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