Eculizumab therapy in paroxysmal nocturnal haemoglobinuria patient undergoing aortic valve surgery.

Abstract:

:Paroxysmal nocturnal haemoglobinuria is a rare disorder characterized by haemolytic anaemia and pancytopaenia. The use of cardiopulmonary bypass can lead to a haemolytic crisis in patients with paroxysmal nocturnal haemoglobinuria due to activation of complement-mediated haemolysis. We report the successful management of a 69-year-old man undergoing aortic valve replacement with standard heparin-protamine protocol by using eculizumab, a monoclonal antibody of complement factor C5. The surgery was performed without triggering a haemolytic crisis, and the patient was discharged from the hospital without major complications.

authors

Kusadokoro S,Kimura N,Hori D,Yamaguchi A

doi

10.1093/icvts/ivz020

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

994-995

issue

6

eissn

1569-9293

issn

1569-9285

pii

5306104

journal_volume

28

pub_type

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