Abstract：
:Kidney stone disease is a common disorder in Western countries that is associated with significant suffering, morbidity, and cost for the healthcare system. Numerous studies have demonstrated familial aggregation of nephrolithiasis and a twin study estimated the heritability to be 56%. Over the past decade, genome-wide association studies have uncovered several sequence variants that confer increased risk of common complex kidney stone disease. The first reported variants were observed at the CLDN14 locus in the Icelandic population. This finding has since been replicated in other populations. The CLDN14 gene is expressed in tight junctions of the thick ascending limb of the loop of Henle, where the protein is believed to play a role in regulation of calcium transport. More recent studies have uncovered variants at the ALPL, SLC34A1, CASR, and TRPV5 loci, the first two genes playing a role in renal handling of phosphate, while the latter two are involved in calcium homeostasis. Although genetic data have provided insights into the molecular basis of kidney stone disease, much remains to be learned about the contribution of genetic factors to stone formation. Nevertheless, the progress made in recent years indicates that exciting times lie ahead in genetic research on kidney stone disease.
journal_name
Urolithiasisjournal_title
Urolithiasisauthors
Palsson R,Indridason OS,Edvardsson VO,Oddsson Adoi
10.1007/s00240-018-1094-2subject
Has Abstractpub_date
2019-02-01 00:00:00pages
11-21issue
1eissn
2194-7228issn
2194-7236pii
10.1007/s00240-018-1094-2journal_volume
47pub_type
杂志文章,评审相关文献
Urolithiasis文献大全abstract：:Pediatric population has increasing incidence of renal calculus and it is estimated to be around 50/10,000 population. The treatment of choice for large and complex stone in anomalous kidney is percutaneous nephrolithotomy (PCNL). The fate of insignificant residual fragment after PCNL in pediatric patients is not well...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-017-0980-3
更新日期：2018-06-01 00:00:00
abstract：:In this review, aspects on the importance of information on urine composition and selection of the most appropriate regimen for prevention of recurrence are discussed. For patients with urolithiasis the treatment is facilitated by urine analysis with estimates of supersaturation levels. Despite lack of strong scientif...
journal_title：Urolithiasis
pub_type： 杂志文章,评审
doi：10.1007/s00240-015-0840-y
更新日期：2016-02-01 00:00:00
abstract：:The objective is to establish whether a pattern of intestinal dysbiosis exists in calcium oxalate (CaOx) lithiasis and, if so, to identify its characteristics and explore whether there are differences in the pattern between CaOx dihydrate (COD) and monohydrate (COM) lithiasis. With this aim 24 patients diagnosed with ...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-020-01181-y
更新日期：2020-08-01 00:00:00
abstract：:To evaluate the role of preoperative procalcitonin (PCT) levels in predicting postoperative fever after mini-percutaneous nephrolithotomy (mini-PCNL) in patients with a negative baseline urine culture. Between January 2014 and October 2017, 329 patients with a negative baseline urine culture and who underwent mini-PCN...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-019-01115-3
更新日期：2019-10-01 00:00:00
abstract：:Urinary stones and urine composition are the first steps in the process of recurrence prevention, but data concerning the association between the two compositions are scarce in Chinese children with urolithiasis. We retrospectively analyzed the records of children (age range 0-18 years) with urolithiasis in our center...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-016-0910-9
更新日期：2017-06-01 00:00:00
abstract：:The goal of this study was to investigate recent changes in stone composition and patient demographics to identify factors influencing stone formation for the purpose of reducing the incidence of urolithiasis and preventing stone recurrence. This retrospective analysis includes patients who underwent percutaneous neph...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-019-01151-z
更新日期：2020-08-01 00:00:00
abstract：:Cystinuria is an autosomal inherited disorder of renal reabsorption of cystine, arginine, lysine, and ornithine. Increased urinary excretion of cystine results in the formation of kidney stones. Considering the few studies on the genetic basis of the cystinuria in the Middle East and the population-specific distributi...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-015-0794-0
更新日期：2015-10-01 00:00:00
abstract：:Measurement of oxalate in the blood is essential for monitoring primary hyperoxaluria patients with progressive renal impairment and on dialysis prior to transplantation. As no external quality assurance scheme is available for this analyte, we conducted a sample exchange scheme between six laboratories specifically i...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-020-01197-4
更新日期：2020-12-01 00:00:00
abstract：:The goal of this study was to investigate metabolic risk factors in pediatric stone formers in an emerging economy. A prospective, data collection enrolled 250 children age <1-15 years at our center. Risk factors were evaluated by gender and in age groups <1-5, 6-10 and 11-15 years. Patients were evaluated for demogra...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-016-0922-5
更新日期：2017-08-01 00:00:00
abstract：:To evaluate the possible role of ureteral wall thickness (UWT) assessment in the prediction of the success for stent placement in cases with obstructing ureteric stones. 227 adult patients with a single unilateral obstructing ureteral stone requiring internal ureteral stent placement were included. In addition to ston...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-020-01233-3
更新日期：2021-01-02 00:00:00
abstract：:The concept of adipose tissue as an organ unto itself represents a new medical construct; already differences in the volume of perirenal fat around a tumor-bearing kidney have been described. We hypothesized that renal calculi may have similar impact on perirenal fat or alternatively abnormalities in urinary metabolit...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-018-1047-9
更新日期：2018-11-01 00:00:00
abstract：:There is a lack of studies looking at the longitudinal follow-up of patients with cystine stones. We wanted to assess the journey of cystinuric patients through our specialist metabolic stone clinic to improve the understanding of episodes, interventions and current outcomes in this patient cohort. After ethical appro...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-018-1059-5
更新日期：2019-04-01 00:00:00
abstract：:The association between mean stone density (MSD) and ureteroscopic lithotripsy outcome remains controversial. MSD automatically measured by 3D images of stones (3D-MSD) was recently reported to be more useful than manual measuring methods for predicting outcomes of shock-wave lithotripsy. This study aims to investigat...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-020-01178-7
更新日期：2020-12-01 00:00:00
abstract：:We performed a randomized, prospective study to assess the possible role of combined a1D-receptor antagonist naftopidil and nonsteroidal anti-inflammatory hormones celecoxib for the spontaneous expulsion of distal ureteral stones. Patients were randomized to one of the three treatment groups. Treatment group 1 patient...
journal_title：Urolithiasis
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00240-014-0708-6
更新日期：2014-12-01 00:00:00
abstract：:Symptomatic prostatic calculi are a rare clinical entity with wide range of management options, however, there is no agreement about the preferred method for treating these symptomatic calculi. In this study we describe our experience of transurethral management of symptomatic prostatic calculi using holmium-YAG laser...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-013-0571-x
更新日期：2013-08-01 00:00:00
abstract：:The objective of the study is to evaluate the safety, efficacy and outcome of multiple tracts percutaneous nephrolithotomy (PCNL) assisted by LithoClast master (the third-generation Electro Medical System) in one session for the treatment of staghorn calculi. From October 2011 to March 2013, 117 patients with staghorn...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-013-0632-1
更新日期：2014-04-01 00:00:00
abstract：:Urinary stone disease is a common, often recurrent disease, that can have a negative impact on patients' health-related quality of life (HRQoL), often effecting working, productive members of society. The literature lacks data from structured, qualitative research which could give unique insight into patients' HRQoL. ...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-019-01142-0
更新日期：2020-06-01 00:00:00
abstract：:Use of extracorporeal lithotripsy is declining in North America and many European countries despite international guidelines advocating it as a first-line therapy. Traditionally, lithotripsy is thought to have poor efficacy at treating lower pole renal stones. We evaluated the success rates of lithotripsy for lower po...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-013-0549-8
更新日期：2013-06-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of seasonal variation and climate parameters on urinary tract stone attack and investigate whether stone attack is increased sharply at a specific point. Nationwide data of total urinary tract stone attack numbers per month between January 2006 and December 2010 were ob...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-014-0741-5
更新日期：2015-02-01 00:00:00
abstract：:Shock wave lithotripsy (SWL) is an established treatment for renal stones. Although non-invasive, it can cause significant pain and anxiety during the procedure. Our purpose was to review the literature to look at the effect of complimentary therapy in patients undergoing SWL and whether it led to a reduction in the r...
journal_title：Urolithiasis
pub_type： 杂志文章,评审
doi：10.1007/s00240-014-0655-2
更新日期：2014-06-01 00:00:00
abstract：:Textbooks describe three narrowest anatomic sites in the ureter as the most likely places for ureteral calculi to lodge, these are: the pelvi-ureteric junction (PUJ), the point where the ureters cross over the iliac vessels and the ureterovesical junction (UVJ). The purpose of this study is to determine whether calcul...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-013-0605-4
更新日期：2014-02-01 00:00:00
abstract：:This study aims to describe the rate and characteristics of transient renal impairment in unilateral ureteric stone patients without chronic kidney disease (CKD) and to identify factors that may have influenced renal function of these patients. Unilateral ureteric stone patients who visited our hospital's emergency de...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-016-0904-7
更新日期：2017-06-01 00:00:00
abstract：:The aim of the study was to compare percutaneous nephrolithotomy (PCNL) and staged retrograde flexible ureteroscopy (FURS) methods used in the treatment of kidney stones of 2 cm or more in diameter. The study comprised a total of 60 patients with a diagnosis of kidney pelvic stones more than 2 cm in diameter, for whom...
journal_title：Urolithiasis
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00240-015-0768-2
更新日期：2015-06-01 00:00:00
abstract：:The objective of this study was to present the outcomes of comparative clinical study of microperc versus mini-percutaneous nephrolithotomy (mini-PNL) in the treatment of lower calyx stones of 10-20 mm. Patients with lower calyx stones treated with microperc (Group-1) or mini-PNL (Group-2) between 2011 and 2014 were r...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-015-0804-2
更新日期：2016-04-01 00:00:00
abstract：:This study aimed to investigate the effectiveness and reliability of micro-percutaneous nephrolithotomy (micro-PNL) for the management of kidney stones in pediatric patients. This retrospective study included 24 infants that underwent micro-PNL for renal stones between March 2012 and April 2015. The inclusion criteria...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-015-0807-z
更新日期：2016-04-01 00:00:00
abstract：:Kidney stone is a chronic metabolic disease that caused by many factors, especially by the metabolic disturbances of urine compositions, but the metabolic profiling of the urine from kidney stone patients remains poorly explored. In the present study, 1H NMR spectroscopy and multivariate pattern recognition analytical...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-019-01132-2
更新日期：2020-02-01 00:00:00
abstract：:Various analgesic applications can be used during extracorporeal shock wave lithotripsy (SWL) for pain relief and maximal success rate. Intracutaneous sterile water injection (ISWI) has been shown to be effective in several types of pain, but a gap exists about its use during SWL. In this paper, we aimed to evaluate t...
journal_title：Urolithiasis
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00240-019-01147-9
更新日期：2020-04-01 00:00:00
abstract：:Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This pilot study was undertaken to assess an adolescent kidney stone cohort'...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-020-01183-w
更新日期：2020-08-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. On page 84, the dose for oral potassium citrate is incorrectly written as "0.1 mg/kg/day divided BID-QID for children, 30-60 mg per day divided BID-QID for adults". ...
journal_title：Urolithiasis
pub_type： 已发布勘误
doi：10.1007/s00240-019-01166-6
更新日期：2020-02-01 00:00:00
abstract：:Kidney stone disease occurs throughout the world. Conservative treatments involving herbal preparations have been used in traditional Chinese medicine. In vitro studies have suggested that Folium pyrrosiae (FP) has therapeutic potential in this context. The present study was undertaken to investigate the effects of in...
journal_title：Urolithiasis
pub_type： 杂志文章
doi：10.1007/s00240-014-0722-8
更新日期：2015-02-01 00:00:00
