Abstract：
BACKGROUND:Autologous transfusion (AT) has long been considered unsafe in major oncologic operations due to a theoretic risk of spreading metastatic disease, however, few data support this assumption. STUDY DESIGN:We conducted a retrospective analysis of 147 patients who underwent partial hepatectomy for colorectal cancer metastases at a single institution. Seventy-four patients received AT only and 73 received no transfusion (NT). We compared the overall survival and recurrence-free survival of these groups using Kaplan-Meier survival curves and adjusted hazard ratios. RESULTS:Patients who received AT had greater blood loss, more extensive resections, and longer procedure times. There were no differences in age, sex, proportion colon vs rectal cancer, or Fong Clinical Risk Score. Mean follow-up was 54 months. Median overall survival in the AT group was 59 months compared with 54 months in the NT group (p = 0.69) on log-rank test. No difference in overall survival was noted after adjusting for age, sex, Fong score, type of cancer (colon vs rectal), receipt of neoadjuvant therapy, receipt of adjuvant therapy, extent of resection and blood loss (hazard ratio AT vs NT 0.58; 95% CI 0.31 to 1.11; p = 0.10). Recurrence-free survival was also similar in the AT and NT groups (27% vs 37%; p = 0.22). The adjusted hazard ratio for recurrence-free survival was 0.95 (95% CI 0.54 to 1.65; p = 0.85). CONCLUSIONS:Autologous blood transfusion is not associated with an increased recurrence risk or a higher mortality rate. Surgeons performing liver resections for patients with colorectal cancer metastases can safely transfuse filtered autologous blood.
journal_name
J Am Coll Surgjournal_title
Journal of the American College of Surgeonsauthors
Kang R,Seath BE,Huang V,Barth RJ Jrdoi
10.1016/j.jamcollsurg.2018.10.020subject
Has Abstractpub_date
2019-06-01 00:00:00pages
902-908issue
6eissn
1072-7515issn
1879-1190pii
S1072-7515(18)32157-4journal_volume
228pub_type
杂志文章abstract：BACKGROUND:Fibulin-5 is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Because fibulin-5 expression is induced dramatically in endot...
journal_title：Journal of the American College of Surgeons
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doi：
更新日期：1995-11-01 00:00:00
