Abstract:
BACKGROUND:Recent studies that investigated the effect of vitamin D on skin cancer risk have exhibited inconsistent results. OBJECTIVE:The aim of the study was to evaluate vitamin D status in patients with actinic keratosis. METHODS:A cross-sectional study was conducted on 31 patients with actinic keratosis and 29 healthy controls. Serum vitamin D levels in the study group were determined by liquid chromatography/tandem mass spectrometry. RESULTS:Serum 25(OH)D levels in patients with actinic keratosis were significantly higher than those of the healthy controls (P=0.04). Prevalence of 25(OH)D deficiency was significantly higher in the healthy controls (75.9%) compared to the patients with actinic keratosis (54.8%), but the difference was not statistically significant (P= 0.09). STUDY LIMITATIONS:The cross-sectional design of the study, data on smoking based on patient self-report, and subjects' different dietary habits, which can influence 25(OH)D levels, are the study's limitations. CONCLUSION:Serum vitamin D level can be used as a marker for ultraviolet B radiation from sun exposure; therefore, it can be used in individuals at risk of actinic keratosis. Oral intake of vitamin D through diet or supplements is proposed instead of prolonged ultraviolet exposure to maintain adequate vitamin D serum levels. Further research is needed to elucidate the role of vitamin D in skin carcinogenesis.
journal_name
An Bras Dermatoljournal_title
Anais brasileiros de dermatologiaauthors
Çerman AA,Karabay EA,Altunay IK,Cesur SKdoi
10.1590/abd1806-4841.20186999subject
Has Abstractpub_date
2018-07-01 00:00:00pages
535-538issue
4eissn
0365-0596issn
1806-4841pii
S0365-05962018000400007journal_volume
93pub_type
杂志文章abstract::Herpes simplex virus type 2 (HSV-2) infections are frequent in HIV (human immunodeficiency virus) infected patients. In those cases, genital herpes may have an atypical clinical presentation. Hypertrophic and vegetating variants are unusual. The authors describe a case of hypertrophic perianal herpes in an HIV patient...
journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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journal_title:Anais brasileiros de dermatologia
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