当前位置： SCI文献检索 > JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond.

Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond.

Abstract：

:The function of the CXCR4/CXCL12 axis accounts for many disease indications, including tissue/nerve regeneration, cancer metastasis, and inflammation. Blocking CXCR4 signaling with its antagonists may lead to moving out CXCR4+ cell types from bone marrow to peripheral circulation. We have discovered a novel series of pyrimidine-based CXCR4 antagonists, a representative (i.e., 16) of which was tolerated at a higher dose and showed better HSC-mobilizing ability at the maximal response dose relative to the approved drug 1 (AMD3100), and thus considered a potential drug candidate for PBSCT indication. Docking compound 16 into the X-ray crystal structure of CXCR4 receptor revealed that it adopted a spider-like conformation striding over both major and minor subpockets. This putative binding mode provides a new insight into CXCR4 receptor-ligand interactions for further structural modifications.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Wu CH,Song JS,Kuan HH,Wu SH,Chou MC,Jan JJ,Tsou LK,Ke YY,Chen CT,Yeh KC,Wang SY,Yeh TK,Tseng CT,Huang CL,Wu MH,Kuo PC,Lee CJ,Shia KS

doi

10.1021/acs.jmedchem.7b01322

subject

Has Abstract

pub_date

2018-02-08 00:00:00

pages

818-833

issue

3

eissn

0022-2623

issn

1520-4804

journal_volume

61

pub_type

杂志文章

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