Abstract:
Purpose::To develop an experimental model of intestinal ischemia and obstruction followed by surgical resection of the damaged segment and reestablishment of intestinal transit, looking at bacterial translocation and survival. Methods::After anesthesia, Wistar rats was subject to laparotomy, intestinal ischemia and obstruction through an ileal ligature 1.5cm of ileum cecal valve; and the mesenteric vessels that irrigate upstream of the obstruction site to approximately 7 to 10 cm were ligated. Abdominal wall was closed. Three, six or twenty-four hours after, rats were subject to enterectomy followed by an end to end anastomosis. After 24h, mesenteric lymph nodes, liver, spleen and lung tissues were surgically removed. It was studied survival rate and bacterial translocation. GraphPadPrism statistical program was used. Results::Animals with intestinal ischemia and obstruction for 3 hours survived 24 hours after enterectomy; 6hx24h: survival was 70% at 24 hours; 24hx24h: survival was 70% and 40%, before and after enterectomy, respectively. Culture of tissues showed positivity on the 6hx24h and negativity on the 3hx24h. Conclusion: :The model that best approached the clinic was the one of 6x24h of ischemia and intestinal obstruction, in which it was observed bacterial translocation and low mortality rate.
journal_name
Acta Cir Brasjournal_title
Acta cirurgica brasileiraauthors
Costa RIDD,Rasslan R,Koike MK,Utiyama EM,Montero EFSdoi
10.1590/s0102-865020170080000006subject
Has Abstractpub_date
2017-08-01 00:00:00pages
641-647issue
8eissn
0102-8650issn
1678-2674pii
S0102-86502017000800641journal_volume
32pub_type
杂志文章abstract:PURPOSE:To assess comparatively the inflammatory response that follows CO(2) or Ringer's lactate joint capsular distension of horses submitted to experimental arthroscopy METHODS:Each animal was submitted to a bilateral tarsocrural arthroscopy employing gas distention in one joint and fluid distention in the contralat...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502012001200004
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:This study was carried out to assess the effects of the aqueous extract of Hyptis pectinata leaves on liver regeneration and on serum enzymes (AST, ALT and gamma-GT) after 67% partial hepatectomy in rats. METHODS:AST, ALT and gamma-GT, were determined by conventional procedures using a spectrophotometer (Model...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502006000700008
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To investigate the effect of primary tumorectomy on angiogenesis and pulmonary metastasis in osteosarcoma-bearing nude mice. METHODS:Osteosarcoma was introduced to nude mice via subcutaneous injection of MG-63 cells. One hundred and eighty osteosarcoma-bearing mice were used equally in 3 parallel experiments. ...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502013000300006
更新日期:2013-03-01 00:00:00
abstract:PURPOSES:This research desenvolved in Rio Grande do Norte Federal University, Department of Dentistry purpose evaluation "in vitro" Ca(OH) and tergentol solutions action in oral cavity that first reside in and cariogenic microorganisms for dental biofilm chemical control increasing. METHODS:"In vitro" tests with antib...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502005000700004
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency. METHODS:The study group consisted of 15 medical residents from Anesthesiology and Surgery areas, of both genders, mainly exposed to isofluran...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502014000400010
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:This study is a systematic literature review and meta-analysis concerning the use of a testosterone synthetic analog, oxandrolone, and its use in severe adult burns. METHODS:Randomized prospective clinical studies, in English, Portuguese or Spanish, were sought on the following databases: MEDLINE, COCHRANE, EM...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章,meta分析,评审
doi:10.1590/s0102-86502014001700013
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To evaluate the mitochondrial function of the remnant liver (RL) in the early phase of liver regeneration in rats after 70% partial hepatectomy (PH). METHODS:Sixty male Wistar rats (200-250g) submitted to 70% PH were divided into five groups according to the time of euthanasia and application or not of laser l...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502011000600011
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. METHODS:The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peri...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-865020180060000003
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To determine biomechanical properties of the superior labrum-biceps tendon complex submitted to continuous and sudden mechanical strain. METHODS:Eighteen shoulder specimens from 15 unclaimed corpses, ages ranging from 20 to 40 years, were submitted to continuous or sudden tensile tests using 3 different tracti...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502006000400005
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To determine the number of podocyte, slit diaphragms, slit diaphragm extensions and GBM thickness in diabetic nephropathy. METHODS:Sixty "Rattus Wistar"of both sexes weighing 200-300 g were divided in two experimental groups: normal group 10 animals, and alloxan diabetic rats--50 animals. Alloxan was administe...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502006000200006
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:To evaluate the rehabilitation of edentulous mandibles with osseous integrated implants in immediate loading, using models in reverse planning. METHODS:A prospective study was performed on 14 patients with a total of 56 implants placed. It was proposed a technique for the rehabilitation of edentulous mandible ...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502007000500011
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:T o investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury. METHODS:A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two ...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/S0102-865020160040000008
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To investigate the effect of cilostazol, in kidney and skeletal muscle of rats submitted to acute ischemia and reperfusion. METHODS:Fourty three animals were randomized and divided into two groups. Group I received a solution of cilostazol (10 mg/Kg) and group II received saline solution 0.9% (SS) by orogastri...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502012001100007
更新日期:2012-11-01 00:00:00
abstract:Purpose: :To evaluate whether undergraduate students feel motivated to develop surgical skills and know their impression about the importance of having a surgical technique discipline in the curriculum of a medical school. Methods: :A prospective study including three classes in a row, from the 8th period (n = 265) ev...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-865020170109
更新日期:2017-01-01 00:00:00
abstract:PURPOSE: :To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface. METHODS: :Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed for 30, 50, 70 and 90 day...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/S0102-865020160120000001
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To investigate the effect of zinc sulphate administered by transdermal iontophoresis (TDI) on mechanical resistance of surgical wounds performed in the skin of diabetic rats. METHODS:One hundred and sixty male Wistar rats weighing approximately 250 g were submitted to an incision surgery at the anterior region...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502013000800008
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin. METHODS:Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures . Rats were divided into four groups which received biopsies on the...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502007000400013
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To compare sciatic nerve regeneration in rats using three different techniques of repair. METHODS:Fifteen isogonics rats were divided into three groups according to the method used to repair a 5-mm long defect created in the sciatic nerve: autogenous graft (Group A), polyglycolic acid tube (PGAt) (Group B), an...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/S0102-86502015001000006
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the effects of exposure of enoxaparin and unfractionated heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of pregnant healthy Wistar rats. METHODS:Enoxaparin and UFH were administered in prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 mg/kg/day 4...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502014000700001
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl2) in rats. METHODS:Rats were pretreated with PFE and consecutively injected with CdCl2 (6.5 mg/kg) for 5 days. RESULTS:The concentration of Cd, kidney weight, malondialdehyde...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-865020190070000006
更新日期:2019-09-12 00:00:00
abstract:PURPOSE:To compare the results of equations for estimate of the indirect maximal oxygen consumption with obtained them in test ergoespirometric in young individuals. METHODS:Fifty-two individuals of the masculine sex were submitted to the test of effort with it analyzes direct of gases in treadmill for the determinati...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine. METHODS:It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats, adults females with a hyper caloric diet. We collected their bloo...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502009000600006
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:To develop a project of hyperbaric chamber that allows its safe and reliable use in veterinary and animal experimentation. METHODS:Based on the technical specifications for the construction of hyperbaric chambers for human beings, it has been developed a design of a chamber with dimensions and characteristics ...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502008000400014
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:To investigate a saddle anesthesia with different doses of chloroprocaine in perianal surgery. METHODS:Total 60 Patients aged 18-75 years (Anesthesiologists grade I or II) scheduled to receive perianal surgery. Patients using saddle anesthesia were randomized to group A, group B and group C with the same conce...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章,随机对照试验
doi:10.1590/S0102-86502014000100010
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To investigate the osteoconductive properties and biological performance of Poly L-lactic acid (PLLA) with omentum in bone defects. METHODS:PLLA nanofiber scaffolds were prepared via electrospinning technique. Forty four New Zealand white female rabbits randomly divided into three groups of 18 rabbits each. Cr...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502012001000005
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To investigate the effects of different conditions used during cardiopulmonary bypass (CPB) surgery on accompanying production of cytokine and nitric oxide (NO). METHODS:Patients undergoing CPB for the first time were prospectively enrolled and divided into two groups according to CPB parameters performed: i) ...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502007000400003
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To evaluate the effect of N-acetylcysteine, as a renoprotective agent, when administered early after anesthesia induction, against ischemia/reperfusion injury in rats anesthetized with isoflurane. METHODS:Eighteen male Wistar rats weighing > 300 g were anesthetized with isoflurane. The internal jugular vein an...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/s0102-86502012000400010
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To assess oxidative stress and the profile of fatty acids incorporated into the hepatic tissue of animals refed with high-fat (HF) diets after acute food restriction. METHODS:Fifty male Wistar rats were divided into five groups and fasting for 48 hours. One group was sacrificed without refeeding (NR), a contro...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/S0102-86502014000300006
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS:Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was recei...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章
doi:10.1590/S0102-865020160070000005
更新日期:2016-07-01 00:00:00
abstract:Purpose: :To identify the most relevant flaws in standardization in husbandry practices and lack of transparency to report them. This review proposes some measures in order to improve transparency, reproducibility and eventually external validity in experimental surgery experiments with rat model. Methods: :We perform...
journal_title:Acta cirurgica brasileira
pub_type: 杂志文章,评审
doi:10.1590/S0102-865020170030000010
更新日期:2017-03-01 00:00:00