Plasmid transfer in biofilms: a perspective on limitations and opportunities.


:Biofilms dominate microbial life, and their importance for human health and the environment can no longer be dismissed. Nevertheless many of the processes governing this form of microbial growth are still poorly understood. This includes the horizontal exchange of genetic information, which is a major driver in bacterial evolution and rapid adaptation, exemplified by the alarming spread of multi-drug resistance among pathogens mediated by plasmids. Biofilms are often considered hot spot for horizontal gene transfer, yet several studies have shown that plasmid transfer is limited to the outer layers. On the basis of results from decades of research we analyse this paradox and discuss the mechanisms by which biofilm growth can promote the initial transfer of some plasmids, but also limit further plasmid invasion into the population or community. If we want to adequately promote or combat horizontal gene spread in biofilms, we need to gain better insight into the physicochemical and biological mechanisms that control this process.


Stalder T,Top E




Has Abstract


2016-01-01 00:00:00






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    journal_title:NPJ biofilms and microbiomes

    pub_type: 杂志文章


    authors: Niederdorfer R,Besemer K,Battin TJ,Peter H

    更新日期:2017-09-25 00:00:00

  • Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth.

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    journal_title:NPJ biofilms and microbiomes

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    authors: Rascovan N,Huynh H,Chouin G,Adekola K,Georges-Zimmermann P,Signoli M,Desfosses Y,Aboudharam G,Drancourt M,Desnues C

    更新日期:2016-12-07 00:00:00

  • How do environment-dependent switching rates between susceptible and persister cells affect the dynamics of biofilms faced with antibiotics?

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    journal_title:NPJ biofilms and microbiomes

    pub_type: 杂志文章


    authors: Carvalho G,Balestrino D,Forestier C,Mathias JD

    更新日期:2018-03-15 00:00:00

  • Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound.

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    journal_title:NPJ biofilms and microbiomes

    pub_type: 杂志文章


    authors: Chung EMC,Dean SN,Propst CN,Bishop BM,van Hoek ML

    更新日期:2017-04-11 00:00:00

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    journal_title:NPJ biofilms and microbiomes

    pub_type: 杂志文章


    authors: Feehily C,Crosby D,Walsh CJ,Lawton EM,Higgins S,McAuliffe FM,Cotter PD

    更新日期:2020-11-12 00:00:00

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    pub_type: 杂志文章


    authors: Bao K,Bostanci N,Thurnheer T,Grossmann J,Wolski WE,Thay B,Belibasakis GN,Oscarsson J

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    pub_type: 杂志文章


    authors: Van den Abbeele P,Marzorati M,Derde M,De Weirdt R,Joan V,Possemiers S,Van de Wiele T

    更新日期:2016-07-27 00:00:00

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    pub_type: 杂志文章


    authors: Powell LC,Pritchard MF,Ferguson EL,Powell KA,Patel SU,Rye PD,Sakellakou SM,Buurma NJ,Brilliant CD,Copping JM,Menzies GE,Lewis PD,Hill KE,Thomas DW

    更新日期:2018-06-29 00:00:00

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    journal_title:NPJ biofilms and microbiomes

    pub_type: 杂志文章


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    更新日期:2018-02-19 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Tan CH,Koh KS,Xie C,Zhang J,Tan XH,Lee GP,Zhou Y,Ng WJ,Rice SA,Kjelleberg S

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    pub_type: 杂志文章


    authors: Koch C,Huber KJ,Bunk B,Overmann J,Harnisch F

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    journal_title:NPJ biofilms and microbiomes

    pub_type: 杂志文章


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    更新日期:2018-04-23 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Kumar A,Alam A,Grover S,Pandey S,Tripathi D,Kumari M,Rani M,Singh A,Akhter Y,Ehtesham NZ,Hasnain SE

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Qu Z,Zhao H,Zhang H,Wang Q,Yao Y,Cheng J,Lin Y,Xie J,Fu Y,Jiang D

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    journal_title:NPJ biofilms and microbiomes

    pub_type: 已发布勘误


    authors: Drewes JL,White JR,Dejea CM,Fathi P,Iyadorai T,Vadivelu J,Roslani AC,Wick EC,Mongodin EF,Loke MF,Thulasi K,Gan HM,Goh KL,Chong HY,Kumar S,Wanyiri JW,Sears CL

    更新日期:2019-01-09 00:00:00