Abstract：
:Science has come a long way with regard to the consideration of sex differences in clinical and preclinical research, but one field remains behind the curve: human statistical genetics. The goal of this commentary is to raise awareness and discussion about how to best consider and evaluate possible sex effects in the context of large-scale human genetic studies. Over the course of this commentary, we reinforce the importance of interpreting genetic results in the context of biological sex, establish evidence that sex differences are not being considered in human statistical genetics, and discuss how best to conduct and report such analyses. Our recommendation is to run stratified analyses by sex no matter the sample size or the result and report the findings. Summary statistics from stratified analyses are helpful for meta-analyses, and patterns of sex-dependent associations may be hidden in a combined dataset. In the age of declining sequencing costs, large consortia efforts, and a number of useful control samples, it is now time for the field of human genetics to appropriately include sex in the design, analysis, and reporting of results.
journal_name
Biol Sex Differjournal_title
Biology of sex differencesauthors
Powers MS,Smith PH,McKee SA,Ehringer MAdoi
10.1186/s13293-017-0136-8subject
Has Abstractpub_date
2017-05-03 00:00:00pages
15issn
2042-6410pii
136journal_volume
8pub_type
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
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doi：10.1186/s13293-017-0131-0
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-017-0129-7
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
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更新日期：2017-08-15 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章,评审
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更新日期：2020-03-11 00:00:00
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-019-0279-x
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journal_title：Biology of sex differences
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更新日期：2012-12-23 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-019-0244-8
更新日期：2019-07-17 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章,评审
doi：10.1186/s13293-019-0223-0
更新日期：2019-02-04 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-016-0098-2
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journal_title：Biology of sex differences
pub_type： 杂志文章
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journal_title：Biology of sex differences
pub_type： 杂志文章
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journal_title：Biology of sex differences
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更新日期：2018-12-22 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章,已发布勘误
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更新日期：2019-02-19 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/2042-6410-3-6
更新日期：2012-02-20 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-015-0039-5
更新日期：2015-10-15 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-016-0110-x
更新日期：2016-11-14 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-019-0256-4
更新日期：2019-08-23 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
doi：10.1186/s13293-019-0229-7
更新日期：2019-04-03 00:00:00
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journal_title：Biology of sex differences
pub_type： 杂志文章
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