当前位置： SCI文献检索 > JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease.

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease.

Abstract：

:We report herein the identification of the rhodium(III) complex [Rh(phq)2(MOPIP)]+ (1) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Zhong HJ,Wang W,Kang TS,Yan H,Yang Y,Xu L,Wang Y,Ma DL,Leung CH

doi

10.1021/acs.jmedchem.6b00250

subject

Has Abstract

pub_date

2017-01-12 00:00:00

pages

497-503

issue

1

eissn

0022-2623

issn

1520-4804

journal_volume

60

pub_type

杂志文章

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