Abstract:
PURPOSE OF THE REPORT:F-FDG PET/CT has been recently proposed as a noninvasive tool for the diagnosis of renal allograft acute rejection (AR) in kidney transplant recipients (KTRs). Still, the influence of kidney function on F-FDG uptake by renal grafts remains unknown. PATIENTS AND METHODS:We retrospectively identified all KTRs who underwent at least one F-FDG PET/CT. Kidney transplant recipients with documented pyelonephritis or AR were excluded. Estimated glomerular filtration rate (eGFR) was assessed using chronic kidney disease (CKD)-EPI equation. Mean standardized uptake values (SUVmean) of renal graft cortex and aorta were measured in 4 and 1 volumes of interest, respectively. Spearman rank correlation coefficient (ρ) and analysis of variance (ANOVA) were performed. RESULTS:Eighty-two KTRs underwent F-FDG PET/CT for tumor staging (n = 46), suspected infection (n = 11), or fever of unknown origin (n = 25). Mean eGFR was 50 ± 19 mL/min per 1.73 m, including CKD stage 1 (n = 3), stage 2 (n = 21), stage 3a (n = 20), stage 3b (n = 29), and stage 4 (n = 9). Mean kidney and aorta SUVmean were 1.8 ± 0.2 and 1.7 ± 0.3, respectively. No significant correlation was observed between eGFR and kidney SUVmean (ρ, 0.119; P, 0.28) or aorta SUVmean (ρ, -0.144; P, 0.20). ANOVA showed no difference of kidney (P, 0.62) and aorta (P, 0.85) SUVmean between CKD groups. Mean coefficient of variation (on the basis of kidney SUVmean of >3 consecutive F-FDG PET/CT in 15 patients with no significant change of eGFR) reached 13.1%. CONCLUSIONS:The uptake of F-FDG by renal allografts within an hour postinjection is not significantly impacted by CKD.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Jadoul A,Lovinfosse P,Weekers L,Delanaye P,Krzesinski JM,Hustinx R,Jouret Fdoi
10.1097/RLU.0000000000001298subject
Has Abstractpub_date
2016-09-01 00:00:00pages
683-7issue
9eissn
0363-9762issn
1536-0229journal_volume
41pub_type
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journal_title:Clinical nuclear medicine
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