Abstract:
:In this paper, a deterministic model characterizing the within-host infection of Hepatitis C virus (HCV) in intrahepatic and extrahepatic tissues is presented. In addition, the model also includes the effect of the cytotoxic T lymphocyte (CTL) immunity described by a linear activation rate by infected cells. Firstly, the non-negativity and boundedness of solutions of the model are established. Secondly, the basic reproduction number R 01 and immune reproduction number R 02 are calculated, respectively. Three equilibria, namely, infection-free, CTL immune response-free and infected equilibrium with CTL immune response are discussed in terms of these two thresholds. Thirdly, the stability of these three equilibria is investigated theoretically as well as numerically. The results show that when R 01 < 1 , the virus will be cleared out eventually and the CTL immune response will also disappear; when R 02 < 1 < R 01 , the virus persists within the host, but the CTL immune response disappears eventually; when R 02 > 1 , both of the virus and the CTL immune response persist within the host. Finally, a brief discussion will be given.
journal_name
J Biol Dynjournal_title
Journal of biological dynamicsauthors
Hu X,Li J,Feng Xdoi
10.1080/17513758.2020.1859632keywords:
["34C12","34D23","92D30","CTL immune response","Virus to cell infection","extrahepatic compartment","global stability","intrahepatic compartment"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
19-34issue
1eissn
1751-3758issn
1751-3766journal_volume
15pub_type
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