Yield of Urinalysis Screening in Pediatric Cancer Survivors.

abstract：PURPOSE:Research using banked tissue is key to advancing risk-stratification and treatment of children with cancer. Knowledge of parental attitudes to ethical issues arising in tissue banking is very limited but essential in obtaining respectful consent. METHODS:One hundred parents of consecutively diagnosed children ...

journal_title：Pediatric blood & cancer

authors： McMurter B,Parker L,Fraser RB,Magee JF,Kozancyzn C,Fernandez CV

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:To determine prognostic factors for local control in the radiotherapeutic management of non-metastatic Ewing sarcoma. PROCEDURE:Forty patients with localized Ewing sarcoma (ES) were treated with primary site RT at one institution. Median RT dose was 55.8 Gy (range, 25.5-76 Gy). Chemotherapy was given to 34 ...

journal_title：Pediatric blood & cancer

authors： Paulino AC,Nguyen TX,Mai WY,Teh BS,Wen BC

更新日期：2007-08-01 00:00:00

abstract：:A contemporaneous presentation of a second breast cancer in a mother and an extremity rhabdomyosarcoma (RMS) in her daughter led to the diagnosis of the Li Fraumeni syndrome (LFS). Although the association between LFS and RMS in young patients is well recognised 1 there are no guidelines as to how this knowledge shoul...

journal_title：Pediatric blood & cancer

authors： Trahair T,Andrews L,Cohn RJ

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The objectives of this study were to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), pharmacokinetics, and anti-tumor effect of irinotecan in pediatric patients with recurrent or refractory malignancies. PROCEDURE:Twenty-three patients between 1 and 21 years of age, with a solid...

journal_title：Pediatric blood & cancer

authors： Bomgaars L,Kerr J,Berg S,Kuttesch J,Klenke R,Blaney SM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The combined inhibition of insulin-growth factor type 1 receptor (IGF-1R) and the mammalian target of rapamycin (mTOR) has shown activity in preclinical models of pediatric sarcoma and in adult sarcoma patients. We evaluated the activity of the anti-IGF-1R antibody cixutumumab with the mTOR inhibitor temsiro...

journal_title：Pediatric blood & cancer

authors： Wagner LM,Fouladi M,Ahmed A,Krailo MD,Weigel B,DuBois SG,Doyle LA,Chen H,Blaney SM

更新日期：2015-03-01 00:00:00

abstract：:Bridging the survival gap for children with cancer, between those (the great majority) in low and middle income countries (LMIC) and their economically advantaged counterparts, is a challenge that has been addressed by twinning institutions in high income countries with centers in LMIC. The long-established partnershi...

journal_title：Pediatric blood & cancer

authors： Barr RD,Antillón Klussmann F,Baez F,Bonilla M,Moreno B,Navarrete M,Nieves R,Peña A,Conter V,De Alarcón P,Howard SC,Ribeiro RC,Rodriguez-Galindo C,Valsecchi MG,Biondi A,Velez G,Tognoni G,Cavalli F,Masera G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PHT) may be the leading cause of death in β-thalassemia patients; however, its pathophysiologic mechanisms are still unclear. Recent studies indicate that asymmetric dimethylarginine (ADMA) plays a role in the initiation and progression of a variety of diseases, especially the cardiov...

journal_title：Pediatric blood & cancer

authors： Mohamed el-S,Ibrahim B,Amr D,Noha el-K,Mokhtar M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Children with sickle cell disease (SCD) and abnormal transcranial Doppler (TCD) ultrasonography have a high risk of stroke, but this risk is greatly reduced when chronic transfusion therapy is administered. The change in TCD velocities during chronic transfusion therapy and rate and frequency of normalizatio...

journal_title：Pediatric blood & cancer

authors： Kwiatkowski JL,Yim E,Miller S,Adams RJ,STOP 2 Study Investigators.

更新日期：2011-05-01 00:00:00

abstract：:Treatment with the nucleoside analog cytarabine has been shown to mimic changes in gene expression associated with downregulation of the EWS-FLI1 oncogene in Ewing sarcoma cell lines, selectively inhibit their growth in vitro, and cause tumor regression in athymic nude mice. For this report cytarabine was studied in v...

journal_title：Pediatric blood & cancer

authors： Houghton PJ,Morton CL,Kang M,Reynolds CP,Billups CA,Favours E,Payne-Turner D,Tucker C,Smith MA

更新日期：2010-12-01 00:00:00

abstract：:A diverse panel of pediatric cancer advocates and experts, whose collective experience spans the continuum of international academic medicine, industry, government research, and cancer advocacy, recently discussed challenges for pediatric cancer research in the context of coronavirus disease 2019 (COVID-19). Specifica...

journal_title：Pediatric blood & cancer

authors： Auletta JJ,Adamson PC,Agin JE,Kearns P,Kennedy S,Kieran MW,Ludwinski DM,Knox LJ,McKay K,Rhiner P,Thiele CJ,Cripe TP

更新日期：2020-09-01 00:00:00

abstract：:Aciclovir prophylaxis was previously given to all immunocompromised patients treated by our unit, following contact with varicella zoster. In 2003, we changed practice according to National Guidelines, giving prophylaxis only to patients without serum varicella zoster immunoglobulin G antibody (VZ IgG) at diagnosis of...

journal_title：Pediatric blood & cancer

authors： Manley S,Mallinson H,Caswell M,Keenan R,Pizer B

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:A feature often seen in adolescent patients with cancer is a lengthy symptom interval, especially in comparison with children. It has been suggested that inadequate awareness of cancer risk among adolescents may play an important role in this study. METHODS:The Società Italiana Adolescenti con Malattie Onco...

journal_title：Pediatric blood & cancer

authors： Magni C,Segrè C,Finzi C,Veneroni L,Clerici CA,Massimino M,Casanova M,Martinella V,Chiaravalli S,Ricci A,Biondi A,Ferrari A

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Childhood cancer survivors (CCS) are at risk of developing long-term morbidity, which is likely to be presented to a primary care physician (PCP). Therefore, insight into CCS's PCP-based health care use is needed. We investigated the volume and underlying health problems of PCP-based health care use and the ...

journal_title：Pediatric blood & cancer

authors： Streefkerk N,Heins MJ,Teepen JC,Feijen EAM,Bresters D,van Dulmen-den Broeder E,van der Heiden-van der Loo M,van den Heuvel-Eibrink MM,van Leeuwen FE,Loonen JJ,van der Pal HJH,Ronckers CM,Versluys AB,Tissing WJE,Korevaar JC,

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Incidence of venous thromboembolism (VTE) in children is reported to be increasing. We examined thrombophilia testing results in children with VTE that presented in inpatient and outpatient settings to explore patterns of thrombophilia testing. PROCEDURE: PATIENTS/METHODS:Children, ages 0-20 years with VTE...

journal_title：Pediatric blood & cancer

authors： Mahajerin A,Obasaju P,Eckert G,Vik TA,Mehta R,Heiny M

更新日期：2014-03-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) accounts for approximately 15% of childhood NHL. Relapsed ALCL represents a formidable challenge because outcome is poor despite the use of high-dose chemotherapy regimens. We report two patients with relapsed T-type and 0-type ALCL who achieved long-term 3rd and 4th remissions wi...

journal_title：Pediatric blood & cancer

authors： Stockklausner C,Behnisch W,Mechtersheimer G,Möller P,Kulozik AE

更新日期：2008-01-01 00:00:00

abstract：:Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disorder of cytotoxic cell function that results in abnormal proliferation of benign lymphocytes and histiocytes in response to infectious stimuli. FHLH generally occurs in very young children, and typically presents with fever, cytopenias, c...

journal_title：Pediatric blood & cancer

authors： Beaty AD,Weller C,Levy B,Vogler C,Ferguson WS,Bicknese A,Knutsen AP

更新日期：2008-05-01 00:00:00

abstract：:Clinically apparent jaundice is unusual in patients with beta-thalassemia major. Co-inheritance of Gilbert syndrome has been reported to cause hyperbilirubinemia in these subjects. Crigler-Najjar syndrome is another rare disorder of bilirubin metabolism caused by mutation in the gene coding the enzyme UGT1A1. We repor...

journal_title：Pediatric blood & cancer

authors： Aggarwal V,Seth A,Sharma S,Aneja S,Sammarco P,Fabiano C

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Currently, there is no standardized treatment for adolescents, aged 15 years or older, with mature B-cell non-Hodgkin lymphoma (B-NHL), although this age group has been reported to have a poorer prognosis than younger patients. PROCEDURE:The present study analyzed the data of 321 patients with B-NHL, enroll...

journal_title：Pediatric blood & cancer

authors： Sekimizu M,Hashimoto H,Mori T,Kobayashi R,Horibe K,Tsurusawa M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:To determine the maximum-tolerated duration and dose-limiting toxicity of a daily schedule of orally administered cyclophosphamide and topotecan in pediatric patients with recurrent or refractory malignant solid tumors. METHODS:Patients received oral cyclophosphamide (50 mg/m2/dose) in the morning followed ...

journal_title：Pediatric blood & cancer

authors： Bowers DC,Aquino VM,Leavey PJ,Bash RO,Journeycake JM,Tomlinson G,Mulne AF,Haynes HJ,Winick NJ

更新日期：2004-01-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopenia (CAMT) is characterised by neonatal thrombocytopenia, with reduced or absent bone marrow megakaryocytes, leading eventually to pancytopenia. The mean age for progression to bone marrow failure is four years, with the earliest reported being six months. We describe a CAMT pat...

journal_title：Pediatric blood & cancer

authors： Stoddart MT,Connor P,Germeshausen M,Ballmaier M,Steward CG

更新日期：2013-09-01 00:00:00

abstract：:Because of increasing survival rates in pediatric oncology, attention is focusing on cancer and its treatment-related side effects. Rehabilitation may reduce their impact. However, the literature does not provide strong evidence regarding rehabilitation pathways. Therefore, the Italian Association of Pediatric Hematol...

journal_title：Pediatric blood & cancer

authors： Rossi F,Ricci F,Botti S,Bertin D,Breggiè S,Casalaz R,Cervo M,Ciullini P,Coppo M,Cornelli A,Esposito M,Ferrarese M,Ghetti M,Longo L,Morri M,Naretto G,Orsini N,Fagioli F,AIEOP Rehabilitation Working Group Members.

更新日期：2020-12-01 00:00:00

abstract：:Infliximab-daclizumab was used to treat acute and chronic liver and gut graft-versus-host disease (GVHD) in two children after standard immunosuppressive therapy failed. Infliximab (10 mg/kg weekly, 4 doses) and daclizumab (1 mg/kg, days 1, 4, 8, 15, and 22) were given over 1 month. In case 1, grade 2 chronic GVHD of ...

journal_title：Pediatric blood & cancer

authors： Rodriguez V,Anderson PM,Trotz BA,Arndt CA,Allen JA,Khan SP

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Children less than 5 years of age with malignant central nervous system (CNS) tumors, continue to have a high rate of morbidity and mortality following administration of conventional therapy. In an attempt to avoid the neurologic sequelae associated with craniospinal radiation, strategies such as high-dose c...

journal_title：Pediatric blood & cancer

authors： Choi LM,Rood B,Kamani N,La Fond D,Packer RJ,Santi MR,Macdonald TJ

更新日期：2008-05-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a primary immunodeficiency that affects the oxidative mechanism of microbial killing of phagocytic cells. The defect is characterized by a lack or severely reduced superoxide anion (O2-) production by phagocytes. Seventy percent of CGD cases are X-linked (X-CGD) and they are caus...

journal_title：Pediatric blood & cancer

authors： Barese CN,Copelli SB,De Matteo E,Zandomeni R,Salgueiro F,Di Giovanni D,Heyworth P,Rivas EM

更新日期：2005-04-01 00:00:00

abstract：:We present three pediatric patients with BRAFV600E mutant high-grade gliomas treated by vemurafenib on a nominative authorization level at our institution. One patient with anaplastic ganglioglioma experienced confirmed partial tumor response and significant clinical improvement and she is alive 20 months after start ...

journal_title：Pediatric blood & cancer

authors： Bautista F,Paci A,Minard-Colin V,Dufour C,Grill J,Lacroix L,Varlet P,Valteau-Couanet D,Geoerger B

更新日期：2014-06-01 00:00:00

abstract：:The treatment of malignancy in cancer predisposition syndromes that also confer exquisite sensitivity to standard chemotherapy and radiation regimens remains a challenge. Bloom syndrome is one such disorder that is caused by a defect in DNA repair, predisposing to the development of early-onset age-related medical con...

journal_title：Pediatric blood & cancer

authors： Fein Levy C,Presswala LS,Slomovic A,Stiefel J,Schulman-Rosenbaum R

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Ispinesib is a highly specific inhibitor of kinesin spindle protein (KSP, HsEg5), a mitotic kinesin required for separation of the spindle poles. Here we report the activity of ispinesib against the in vitro and in vivo panels of the Pediatric Preclinical Testing Program (PPTP). PROCEDURES:Ispinesib was tes...

journal_title：Pediatric blood & cancer

authors： Carol H,Lock R,Houghton PJ,Morton CL,Kolb EA,Gorlick R,Reynolds CP,Maris JM,Keir ST,Billups CA,Smith MA

更新日期：2009-12-15 00:00:00

abstract：:While encapsulated bacterial agents, particularly Streptococcus pneumoniae, are recognized as important microbes that are associated with serious illness in hosts with sickle cell disease (SCD), multiple pathogens are implicated in infectious manifestations of SCD. Variations in clinical practice have been an obstacle...

journal_title：Pediatric blood & cancer

authors： Obaro SK,Iroh Tam PY

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The outcome for patients with Ewing sarcoma family of tumors (ESFTs) of bone with metastases at diagnosis remains poor despite new approaches to treatment. We evaluated whether a dose-intensity chemotherapy regimen improved survival for patients with ESFTs of bone with metastases at diagnosis. METHODS:We en...

journal_title：Pediatric blood & cancer

authors： Miser JS,Goldsby RE,Chen Z,Krailo MD,Tarbell NJ,Link MP,Fryer CJ,Pritchard DJ,Gebhardt MC,Dickman PS,Perlman EJ,Meyers PA,Donaldson SS,Moore SG,Rausen AR,Vietti TJ,Grier HE

更新日期：2007-12-01 00:00:00

abstract：:Bereaved families fear their child being forgotten by those who knew their loved child, including their child's oncology team. Thoughtfully timed, family-centric condolences shared by pediatric oncology team members have the potential to extend our compassion and kindness toward a family during the darkness of grief. ...

journal_title：Pediatric blood & cancer

authors： Weaver MS,Lichtenthal WG,Larson K,Wiener L

更新日期：2019-02-01 00:00:00