Association between microRNA-196A2 and microRNA-146A polymorphisms and progression to cirrhosis and hepatocellular carcinoma in patients with viral hepatitis B.


BACKGROUND/AIM:MicroRNAs (miRNAs) are small noncoding RNAs that have been implicated in mechanisms underlying various types of cancers including hepatocellular carcinoma (HCC). Reports have indicated that single nucleotide polymorphisms in miRNA-196A2 and miRNA-146A genes may contribute to the risk of progression of hepatitis B virus (HBV) infection to cirrhosis and HCC. This study aimed to examine the effect of miRNA-196A2 and miRNA-146A polymorphisms on the progression of HBV infection to cirrhosis and/or HCC in HBV patients in the Malaysian population. PATIENTS AND METHODS:This study consists of 423 chronic HBV patients without either cirrhosis or HCC and 103 chronic HBV patients diagnosed with liver cirrhosis or with cirrhosis and HCC. The single nucleotide polymorphisms of miRNA-196A2 (rs12304647 and rs11614913) and miRNA-146A (rs2910164) were genotyped using the Sequenom MassARRAY platform. RESULTS:The genotype distribution in chronic HBV without either cirrhosis or HCC, relative to chronic HBV patients diagnosed with liver cirrhosis or with cirrhosis and HCC revealed that rs12304647 has a protective effect from the development of HCC (odds ratio=0.37, 95% confidence interval=0.15-0.89, P=0.027). However, rs11614913 and rs2910164 were not significantly associated with progression of the HBV infection. CONCLUSION:In summary, rs12304647 is associated with a reduced risk of progression to HCC in patients with chronic HBV infection.


Pharmacogenet Genomics


Riazalhosseini B,Mohamed Z,Apalasamy YD,Eng HS,Mohamed R




Has Abstract


2016-02-01 00:00:00












  • Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach.

    abstract::P-glycoprotein, the product of the ABCB1 gene, is a proposed mechanism of pharmacoresistance in epilepsy. Previous attempts to correlate the ABCB1 C3435T SNP, or a three-SNP haplotype containing C3435T with epilepsy pharmacoresistance have produced discordant findings. We analysed these single nucleotide polymorphisms...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章,meta分析


    authors: Leschziner GD,Andrew T,Leach JP,Chadwick D,Coffey AJ,Balding DJ,Bentley DR,Pirmohamed M,Johnson MR

    更新日期:2007-03-01 00:00:00

  • Effect of angiotensin-converting enzyme tag single nucleotide polymorphisms on the outcome of patients with traumatic brain injury.

    abstract:BACKGROUND:Genetic variants appear to influence, at least to some degree, the extent of brain injury and the clinical outcome of patients who have sustained a traumatic brain injury (TBI). Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that is implicated in the regulation of blood pressure and cerebral ...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Dardiotis E,Paterakis K,Siokas V,Tsivgoulis G,Dardioti M,Grigoriadis S,Simeonidou C,Komnos A,Kapsalaki E,Fountas K,Hadjigeorgiou GM

    更新日期:2015-10-01 00:00:00

  • Association of sirolimus adverse effects with m-TOR, p70S6K or Raptor polymorphisms in kidney transplant recipients.

    abstract:BACKGROUND:The mammalian target of rapamycin (m-TOR) inhibitor sirolimus is an immunosuppressive drug used in kidney transplantation. m-TOR binds with Raptor and phosphorylates p70S6 kinase, a protein involved in numerous cell signalling pathways. We examined the association of candidate polymorphisms in m-TOR, Raptor ...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Woillard JB,Kamar N,Rousseau A,Rostaing L,Marquet P,Picard N

    更新日期:2012-10-01 00:00:00

  • Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.

    abstract:OBJECTIVE:Nicotine, the main addictive ingredient in tobacco, is metabolically inactivated to cotinine primarily by the hepatic enzyme CYP2A6. Considerable genetic variation in the CYP2A6 gene results in large variation in the rates of nicotine metabolism, which in turn alters smoking behaviours (e.g. amount of cigaret...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Piliguian M,Zhu AZ,Zhou Q,Benowitz NL,Ahluwalia JS,Sanderson Cox L,Tyndale RF

    更新日期:2014-02-01 00:00:00

  • Strongly increased exposure of meloxicam in CYP2C9*3/*3 individuals.

    abstract:OBJECTIVE:The effects of CYP2C9*1/*3 and *3/*3 genotypes on the pharmacokinetics and pharmacodynamics of meloxicam were evaluated in healthy Korean subjects. METHODS:After oral administration of 15 mg meloxicam, the plasma concentrations of meloxicam were assessed in 11 CYP2C9*1/*1 individuals, eight CYP2C9*1/*3 indiv...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Lee HI,Bae JW,Choi CI,Lee YJ,Byeon JY,Jang CG,Lee SY

    更新日期:2014-02-01 00:00:00

  • The relevance of the individual screening for genetic variants in predicting ovarian response.

    abstract:OBJECTIVE:To investigate if polymorphisms of some genes involved in folliculogenesis predict ovarian response. METHODS:This prospective randomized study includes 124 egg donors genotyped for six SNPs ESR1 (rs2234693), AMHR2 (rs2002555), GDF-9 (rs10491279 and rs254286), AMH (rs10407022) and LHCBR (rs229327) genes and f...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Lledó B,Llácer J,Blanco L,Ortiz JA,Morales R,Fabregat A,Guerrero J,Bernabeu R

    更新日期:2019-11-01 00:00:00

  • Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab.

    abstract::The study aimed to investigate whether polymorphisms in genes of the EGFR signaling pathway are associated with clinical outcome in advanced colorectal cancer (CRC) patients treated with single-agent Cetuximab. Polymorphisms of interest in the EGFR pathway include: cyclin D1 (CCND1) A870G, cyclooxygenase 2 (Cox-2) G-7...

    journal_title:Pharmacogenetics and genomics

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Zhang W,Gordon M,Press OA,Rhodes K,Vallböhmer D,Yang DY,Park D,Fazzone W,Schultheis A,Sherrod AE,Iqbal S,Groshen S,Lenz HJ

    更新日期:2006-07-01 00:00:00

  • Association between caffeine intake and risk of Parkinson's disease among fast and slow metabolizers.

    abstract:INTRODUCTION:Cytochrome P450 1A2 (CYP 1A2) is responsible for more than 90% of caffeine clearance. A polymorphic variant of CYP1A2 (-163C>A) (rs762551) is associated with high CYP1A2 inducibility. Both caffeine and its main metabolite, paraxanthine, may be neuroprotective. The association between caffeine intake and ri...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Tan EK,Chua E,Fook-Chong SM,Teo YY,Yuen Y,Tan L,Zhao Y

    更新日期:2007-11-01 00:00:00

  • CYP2C9 variants as a risk modifier of NSAID-related gastrointestinal bleeding: a case-control study.

    abstract:OBJECTIVE:The aim of this study was to assess whether the CYP2C9*2 and/or *3 variants might modify the risk for NSAID-related upper gastrointestinal bleeding (UGIB) in NSAID users. PATIENTS AND METHODS:We conducted a multicenter, case-control study in which cases were patients aged more than 18 years with a diagnosis ...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Figueiras A,Estany-Gestal A,Aguirre C,Ruiz B,Vidal X,Carvajal A,Salado I,Salgado-Barreira A,Rodella L,Moretti U,Ibáñez L,EMPHOGEN group.

    更新日期:2016-02-01 00:00:00

  • Application of T cell-based transcriptomics to identify three candidate biomarkers for monitoring anti-TGFbetaR therapy.

    abstract:OBJECTIVES:The development of targeted drugs would greatly benefit from the simultaneous identification of biomarkers to determine the aspects of bioactivity, drug safety and efficacy, particularly when affecting receptor-signaling pathways. However, the establishment of appropriate systems to monitor drug-induced even...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Classen S,Muth C,Debey-Pascher S,Eggle D,Beyer M,Mallmann MR,Rudlowski C,Zander T,Pölcher M,Kuhn W,Lahn M,Schultze JL,Staratschek-Jox A

    更新日期:2010-03-01 00:00:00

  • Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity.

    abstract:OBJECTIVE:To determine whether polymorphisms in the sulfonamide detoxification genes, CYB5A (encoding cytochrome b(5)), CYB5R3 (encoding cytochrome b(5) reductase), or NAT2 (encoding N-acetyltransferase 2) were over-represented in patients with delayed sulfonamide drug hypersensitivity, compared with control patients w...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Sacco JC,Abouraya M,Motsinger-Reif A,Yale SH,McCarty CA,Trepanier LA

    更新日期:2012-10-01 00:00:00

  • Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers.

    abstract:AIM:A finite number of variants in the OPRM1, COMT, MC1R, ABCB1 and CYP2D6 genes has been identified to significantly modulate the effects of opioids in controlled homogenous settings. We analyzed the imprint of these variants in opioid therapy in a highly variable cohort of pain patients treated in outpatient units to...

    journal_title:Pharmacogenetics and genomics

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Lötsch J,von Hentig N,Freynhagen R,Griessinger N,Zimmermann M,Doehring A,Rohrbacher M,Sittl R,Geisslinger G

    更新日期:2009-06-01 00:00:00

  • Association of glucocorticoid receptor haplotypes with body composition and metabolic parameters in HIV-infected patients from the FRAM study.

    abstract:BACKGROUND:HIV infection has been associated with dyslipidemia, insulin resistance, and changes in body composition, including loss of subcutaneous fat and skeletal muscle, with relative sparing of upper trunk and visceral fat. Because of its resemblance to Cushing's syndrome, caused by glucocorticoid excess, we hypoth...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Manenschijn L,Scherzer R,Koper JW,Danoff A,van Rossum EF,Grunfeld C

    更新日期:2014-03-01 00:00:00

  • Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.

    abstract:BACKGROUND:5-Hydroxytryptamine 3 (5-HT3) receptors mediate the fast excitatory neurotransmission of serotonin. In this study, we have characterized the effects of four naturally occurring, nonsynonymous variants of the human 5-HT3B subunit on expression and signalling properties of heteromeric 5-HT3AB receptors. METHO...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Krzywkowski K,Davies PA,Irving AJ,Bräuner-Osborne H,Jensen AA

    更新日期:2008-12-01 00:00:00

  • Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice.

    abstract:BACKGROUND:For prevention of joint destruction in rheumatoid arthritis, optimal management of therapy with disease-modifying antirheumatic drugs is essential. Pharmacogenomic evidence, if reliable, may be incorporated in the treatment of rheumatoid arthritis to achieve a more efficient activity control with minimized a...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Taniguchi A,Urano W,Tanaka E,Furihata S,Kamitsuji S,Inoue E,Yamanaka M,Yamanaka H,Kamatani N

    更新日期:2007-06-01 00:00:00

  • Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study.

    abstract:OBJECTIVE:The aim of this study was to investigate whether there is a genotype-by-treatment interaction in patients experiencing stroke and treated with one of three antihypertensive drugs, that is chlorthalidone, amlodipine, or lisinopril. PARTICIPANTS AND METHODS:A population of 436 African Americans and 539 whites ...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Sørensen IF,Vazquez AI,Irvin MR,Sørensen P,Davis BR,Ford CE,Boerwinkle E,Eckfeldt JH,Arnett DK

    更新日期:2014-11-01 00:00:00

  • MicroRNA profiling in K-562 cells under imatinib treatment: influence of miR-212 and miR-328 on ABCG2 expression.

    abstract:BACKGROUND:Despite the enormous success of imatinib in chronic myeloid leukemia (CML), therapy resistance has emerged in a significant proportion of patients, partly because of the overexpression of ABC efflux transporters. METHODS:Using an array comprising 667 miRNAs, we investigated whether the expression of microRN...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Turrini E,Haenisch S,Laechelt S,Diewock T,Bruhn O,Cascorbi I

    更新日期:2012-03-01 00:00:00

  • Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol.

    abstract:OBJECTIVES:To evaluate whether ABCC2 gene polymorphisms are associated with expression and/or function of the efflux pump. METHODS:We investigated the allele frequency of ABCC2 -24C>T, -23G>A, c.1249G>A, c.1446C>G, c.1457C>T, c.2302C>T, c.2366C>T, c.3542G>T, c.3561G>A, c.3563T>A, c.3972C>T, c.4348G>A, and 4544G>A in 3...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Haenisch S,May K,Wegner D,Caliebe A,Cascorbi I,Siegmund W

    更新日期:2008-04-01 00:00:00

  • Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.

    abstract::Lipid changes with statin treatments vary greatly between individuals for reasons which are largely unknown. This study was performed to examine the genetic determinants of lipid responses to rosuvastatin in Chinese patients. A total of 125 polymorphisms in 61 candidate genes from 386 Chinese patients were analyzed fo...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Hu M,Lui SS,Mak VW,Chu TT,Lee VW,Poon EW,Tsui TK,Ko GT,Baum L,Tam LS,Li EK,Tomlinson B

    更新日期:2010-10-01 00:00:00

  • A novel ABCC6 haplotype is associated with azathioprine drug response in myasthenia gravis.

    abstract:OBJECTIVE:We investigated the association of single nucleotide polymorphisms (SNPs) in drug-metabolizing enzymes and transporters (DMETs) with the response to azathioprine (AZA) in patients affected by myasthenia gravis (MG) to determine possible genotype-phenotype correlations. PATIENTS AND METHODS:Genomic DNA from 1...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Colleoni L,Galbardi B,Barzago C,Bonanno S,Franzi S,Frangiamore R,Camera G,Foti M,Biancolini D,Canioni E,Maggi L,Antozzi C,Mantegazza R,Bernasconi P,Kapetis D

    更新日期:2017-02-01 00:00:00

  • Characterization of intron-1 haplotypes of the G protein beta 4 subunit gene--association with survival and progression in patients with urothelial bladder carcinoma.

    abstract:PURPOSE:Polymorphisms in genes encoding subunits of heterotrimeric G proteins have been repeatedly associated with various cancers. As G beta gamma signaling is presumed to be involved in proliferation and invasion processes, we analyzed genetic variations in regulatory regions of GNB4, which encodes the G beta 4 subun...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Riemann K,Struwe H,Eisenhardt A,Obermaier B,Schmid KW,Siffert W

    更新日期:2008-11-01 00:00:00

  • CYP3A5 genotype is associated with elevated blood pressure.

    abstract::The present study aimed to determine whether a polymorphism in CYP3A5, encoding the major CYP3A enzyme in the human kidney, is associated with blood pressure in Caucasians. A homogenous group of 115 young, white male students with normal or mildly elevated, but untreated blood pressure was included. Blood pressure was...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Fromm MF,Schmidt BM,Pahl A,Jacobi J,Schmieder RE

    更新日期:2005-10-01 00:00:00

  • Experimental validation of data mined single nucleotide polymorphisms from several databases and consecutive dbSNP builds.

    abstract::Rapid development in the annotation of human genetic variation has increased the numbers of single nucleotide polymorphisms (SNPs) in candidate genes by several orders of magnitude. The selection of both useful target SNPs for disease-gene association studies and SNPs associated with the treatment response is therefor...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Edvardsen H,Irene Grenaker Alnaes G,Tsalenko A,Mulcahy T,Yuryev A,Lindersson M,Lien S,Omholt S,Syvänen AC,Børresen-Dale AL,Kristensen VN

    更新日期:2006-03-01 00:00:00

  • MicroRNA targets: potential candidates for indirect regulation by drugs.

    abstract:BACKGROUND:Gene expression is regulated by trans-acting transcription factors and microRNAs (miRNAs) through interactions with their respective cis-regulatory elements. The effects that drugs induce result from complex interactions in pathways downstream from their primary targets. These interactions, from gene regulat...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Arora A

    更新日期:2015-03-01 00:00:00

  • Meta-analysis and systematic review of the effect of the donor and recipient CYP3A5 6986A>G genotype on tacrolimus dose requirements in liver transplantation.

    abstract:OBJECTIVE:A meta-analysis was carried out of published studies on the effect of the CYP3A5 6986A>G polymorphism in liver donors and transplant recipients on tacrolimus pharmacokinetics. METHODS:Cohort studies that evaluated the relationship between the CYP3A5 polymorphism in liver donors and transplant recipients and ...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章,meta分析,评审


    authors: Rojas LE,Herrero MJ,Bosó V,García-Eliz M,Poveda JL,Librero J,Aliño SF

    更新日期:2013-10-01 00:00:00

  • Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients.

    abstract:OBJECTIVE:The immunosuppressive drug tacrolimus requires strict therapeutic monitoring due to its narrow therapeutic index and great inter-individual variability. Cytochrome P450 3A4 (Cyp3A4) and Cyp3A5 are the most important contributors to tacrolimus metabolism while the P-glycoprotein pump (MDR-1) modulates its bioa...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Roy JN,Barama A,Poirier C,Vinet B,Roger M

    更新日期:2006-09-01 00:00:00

  • ADH4 intronic variations are associated with alcohol dependence: results from an Italian case-control association study.

    abstract:OBJECTIVES:This study investigated the involvement of ADH4 gene polymorphisms in the susceptibility to alcohol use disorders. METHODS:Thirty-eight single-nucleotide polymorphisms (SNPs) in and around the ADH4 gene were investigated in 136 Italian alcoholics and 276 healthy controls. A new approach based on a bioinform...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Turchi C,Piva F,Solito G,Principato G,Buscemi L,Tagliabracci A

    更新日期:2012-02-01 00:00:00

  • Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions.

    abstract:BACKGROUND:Co-trimoxazole is a sulfonamide-containing antibiotic that is effective in the treatment of several infections and for prophylaxis of Pneumocystis jiroveci pneumonia. This drug has been reported as a common culprit drug for the Stevens-Johnson syndrome (SJS) and for toxic epidermal necrolysis (TEN). Human le...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Kongpan T,Mahasirimongkol S,Konyoung P,Kanjanawart S,Chumworathayi P,Wichukchinda N,Kidkeukarun R,Preechakul S,Khunarkornsiri U,Bamrungram W,Supharatwattanakun B,Mootsikapun P,Kwangsukstid S,Denjanta S,Vannaprasaht S,Rungap

    更新日期:2015-08-01 00:00:00

  • Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population.

    abstract:BACKGROUND AND AIM:Genetic variants in the mammalian target of rapamycin (mTOR) gene have become an interesting topic for the study of genetic susceptibility to cancer, but their associations with the risk of gastric cancer have not been fully investigated. MATERIALS AND METHODS:In a hospital-based case-control study ...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Wang MY,Li QX,He J,Qiu LX,Wang YN,Li J,Sun MH,Wang XF,Yang YJ,Wang JC,Jin L,Wei QY

    更新日期:2015-11-01 00:00:00

  • ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein.

    abstract:BACKGROUND:P-glycoprotein (P-gp) is a multidrug efflux transporter that has a defined role in the absorption and disposition of drugs. Many studies have investigated the potential influence of ABCB1 polymorphisms on the disposition of its substrates. However, there remains significant controversy regarding the role of ...

    journal_title:Pharmacogenetics and genomics

    pub_type: 杂志文章


    authors: Dickens D,Owen A,Alfirevic A,Pirmohamed M

    更新日期:2013-06-01 00:00:00