Pathogenic potential of Escherichia coli clinical strains from orthopedic implant infections towards human osteoblastic cells.

abstract：:The IgG antibody responses to pneumococcal surface protein A (PspA) and capsular polysaccharides in acute and convalescent-phase sera from 10 adult patients with invasive pneumococcal disease were analysed. The relatedness between the strains were characterized by capsular serotyping (1, 4, 7F, 9V, 12F and 19F), multi...

journal_title：Pathogens and disease

authors： Kolberg J,Aase A,Naess LM,Aaberge IS,Caugant DA

更新日期：2014-02-01 00:00:00

abstract：:There is a need for more accurate Chlamydia trachomatis (CT) IgG antibody tests for tubal factor infertility (TFI) diagnostics. We evaluated the predictive value for TFI of Medac ELISA plus (MOMP) and multitarget Mikrogen ELISA (MOMP-CPAF-TARP). Based on Medac ELISA plus results, 183 subfertile women underwent either ...

journal_title：Pathogens and disease

authors： van Ess EF,Ouburg S,Spaargaren J,Land JA,Morré SA

更新日期：2017-09-29 00:00:00

abstract：:This work was aimed at studying the Mycobacterium tuberculosis H37Rv Rv3494c protein, taking into account that it belongs to the mammalian cell entry family (mce) which is thought to have important functions in the disease's pathogenesis. The protein was characterized in silico; its presence on mycobacterial surface w...

journal_title：Pathogens and disease

authors： Rodríguez DC,Ocampo M,Varela Y,Curtidor H,Patarroyo MA,Patarroyo ME

更新日期：2015-04-01 00:00:00

abstract：:Recently, it has been suggested that the oral administration of Porphyromonas gingivalis, a keystone pathogen for periodontal disease, induces dysbiosis of the mouse intestinal microbiota and affects intestinal barrier function. Since oral streptococci are the predominant oral bacterial group, we compared the effect o...

journal_title：Pathogens and disease

authors： Kobayashi R,Ogawa Y,Hashizume-Takizawa T,Kurita-Ochiai T

更新日期：2020-04-01 00:00:00

abstract：:Ticks are one of the principal arthropod vectors of human and animal infectious diseases. Whereas the prevalence of tick-borne encephalitis virus in ticks in Europe is well studied, there is less information available on the prevalence of the other tick-borne viruses (TBVs) existing worldwide. The aim of this study wa...

journal_title：Pathogens and disease

authors： Gondard M,Michelet L,Nisavanh A,Devillers E,Delannoy S,Fach P,Aspan A,Ullman K,Chirico J,Hoffmann B,van der Wal FJ,de Koeijer A,van Solt-Smits C,Jahfari S,Sprong H,Mansfield KL,Fooks AR,Klitgaard K,Bødker R,Moutaill

更新日期：2018-11-01 00:00:00

abstract：:Brachyspira hampsonii causes dysentery-like disease in infected pigs. Serial passage of a virulent swine isolate (P13) one-hundred times in laboratory culture medium was conducted to produce an attenuated strain, and to identify genomic determinants of virulence through comparison of genome sequences of the original a...

journal_title：Pathogens and disease

authors： Perez JBDS,Fernando C,Nosach RV,Huang Y,Harding JCS,Hill JE

更新日期：2018-02-01 00:00:00

abstract：:Mechanically ventilated patients often develop ventilator-associated pneumonia (VAP). Soon after intubation, a mixed biofilm harboring microbial pathogens is formed on the endotracheal tube (ET). It is believed that this biofilm contributes to the development of VAP. Unfortunately, the causative agent is often not kno...

journal_title：Pathogens and disease

authors： Vandecandelaere I,Matthijs N,Nelis HJ,Depuydt P,Coenye T

更新日期：2013-11-01 00:00:00

abstract：:Quorum sensing (QS) plays an important role during the aetiology of urinary tract infection (UTI), as several virulence factors are under the regulation of QS. Pseudomonas aeruginosa and Serratia marcescens, the primary causative agents of UTI, employ acyl homoserine lactone (AHL) as signal molecules to coordinate var...

journal_title：Pathogens and disease

authors： Rubini D,Banu SF,Subramani P,Hari BNV,Gowrishankar S,Pandian SK,Wilson A,Nithyanand P

更新日期：2019-02-01 00:00:00

abstract：:The emergence of Klebsiella pneumoniae multidrug-resistant strains paves the way to the re-introduction of colistin as a salvage therapy. However, recent planktonic studies have reported several cases of heteroresistance to this antimicrobial agent. The aim of this present work was to gain better understanding about t...

journal_title：Pathogens and disease

authors： Silva A,Sousa AM,Alves D,Lourenço A,Pereira MO

更新日期：2016-07-01 00:00:00

abstract：:Streptococcus equi ssp. zooepidemicus (S. zooepidemicus) is responsible for a wide variety of infections in many species. Fibronectin-binding protein is a bacterial cell surface protein, which specifically binds fibronectin (FN). Considering the specific role of FN-binding protein in host-pathogen interactions, we inv...

journal_title：Pathogens and disease

authors： Yi L,Wang Y,Ma Z,Zhang H,Li Y,Zheng JX,Yang YC,Lu CP,Fan HJ

更新日期：2013-04-01 00:00:00

abstract：:The adaptive immune system is expected to protect the host from infectious agents and malignancies, while avoiding robust activation against self-peptides. However, T cells are notoriously inept at protection whenever the pathogen or tumor is persistent in the body for longer periods of time. While this has been thoug...

journal_title：Pathogens and disease

authors： Singh NJ

更新日期：2016-10-01 00:00:00

abstract：:Acinetobacter baumannii is a major causative agent of healthcare-associated infection and develops multidrug resistance rapidly. However, little is known in the host defense mechanisms against this infection. In this study, we examined if mice recovered from a previous intranasal A. baumannii infection (recovered mice...

journal_title：Pathogens and disease

authors： Qiu H,Li Z,KuoLee R,Harris G,Gao X,Yan H,Xu HH,Chen W

更新日期：2016-07-01 00:00:00

abstract：:Staphylococcus epidermidis is frequently associated with the emergence of medical-device-associated bloodstream infections, due to its ability to form biofilms on the surface of vascular catheters. Although these biofilms may be in continuous contact with human blood, how S. epidermidis biofilm cells interact with blo...

journal_title：Pathogens and disease

authors： França A,Cerca N

更新日期：2016-03-01 00:00:00

abstract：:Chlamydiae are obligate intracellular bacteria that share a unique but remarkably conserved biphasic developmental cycle that relies on a eukaryotic host cell for survival. Although the phylum was originally thought to only contain one family, the Chlamydiaceae, a total of nine families are now recognized. These so-ca...

journal_title：Pathogens and disease

authors： Taylor-Brown A,Vaughan L,Greub G,Timms P,Polkinghorne A

更新日期：2015-02-01 00:00:00

abstract：:Salmonella is an enteric pathogen that causes a range of diseases in humans. Non-typhoidal Salmonella (NTS) serovars such as Salmonella enterica serovar Typhimurium generally cause a self-limiting gastroenteritis whereas typhoidal serovars cause a systemic disease, typhoid fever. However, S. Typhimurium isolates withi...

journal_title：Pathogens and disease

authors： Carden S,Okoro C,Dougan G,Monack D

更新日期：2015-06-01 00:00:00

abstract：:Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines a...

journal_title：Pathogens and disease

authors： Brummelman J,Wilk MM,Han WG,van Els CA,Mills KH

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:In order to cope with the rapid spread of the COVID-19 pandemic, we introduced on our in-house high-throughput molecular diagnostic platform (MDx Platform) a real-time reverse transcriptase PCR (RT-PCR) to detect the SARS-CoV-2 from any clinical specimens. The aim of this study was to compare the RT-PCR resu...

journal_title：Pathogens and disease

authors： Opota O,Brouillet R,Greub G,Jaton K

更新日期：2020-11-11 00:00:00

abstract：:The subspecies classification of Mycobacteroides abscessus complex into M. abscessus, M. massiliense and M. bolletii requires the amplification and sequencing of multiple genes. The objective of this study was to evaluate the possibility of subspecies classification using a single PCR target. An in silico study was pe...

journal_title：Pathogens and disease

authors： Ng HF,Ngeow YF

更新日期：2020-11-11 00:00:00

abstract：:Helicobacter pylori infection and H. pylori-related gastric inflammation can be considered as the most significant promoter of gastric cancer (GC). Recent investigations have evaluated the regulatory function of microRNAs (miRNAs) in H. pylori pathogenesis and H. pylori-related diseases, especially GC. The present stu...

journal_title：Pathogens and disease

authors： Dastmalchi N,Safaralizadeh R,Banan Khojasteh SM

更新日期：2019-06-01 00:00:00

abstract：:Gliotoxin (GT) belongs to the epipolythiodioxopiperazine class of toxins secreted from certain fungi including Aspergillus fumigatus, which is the most prolific producer of this secondary metabolite. Recently, enhanced amounts of GT were found in in vitro biofilm-grown A. fumigatus mycelium. To further correlate the A...

journal_title：Pathogens and disease

authors： Bugli F,Paroni Sterbini F,Cacaci M,Martini C,Lancellotti S,Stigliano E,Torelli R,Arena V,Caira M,Posteraro P,Sanguinetti M,Posteraro B

更新日期：2014-04-01 00:00:00

abstract：:The modulation of T cell responses by Helicobacter pylori is thought to potentiate both H. pylori persistence and development of gastric pathologies including cancer. Release of outer membrane vesicles (OMV) by H. pylori provides a potential vehicle for modulation of the immune system. Although OMV are thought to have...

journal_title：Pathogens and disease

authors： Hock BD,McKenzie JL,Keenan JI

更新日期：2017-06-01 00:00:00

abstract：:Chlamydia trachomatis, an obligate intracellular pathogen, has various effective strategies to regulate host cell death signalling pathways that ensure completion of their growth cycle. Mitochondrial autophagy (mitophagy) is responsible for elimination of dysfunctional and impaired mitochondria, and this process plays...

journal_title：Pathogens and disease

authors： Lei W,Li Q,Su S,Bu J,Huang Q,Li Z

更新日期：2017-12-29 00:00:00

abstract：:There is an urgent need to improve methods used to screen antituberculosis drugs. An in vitro assay was developed to test drug treatment strategies that specifically target drug-tolerant Mycobacterium tuberculosis. The H37Rv strain of M. tuberculosis survived antimicrobial treatment as attached microbial communities w...

journal_title：Pathogens and disease

authors： Ackart DF,Hascall-Dove L,Caceres SM,Kirk NM,Podell BK,Melander C,Orme IM,Leid JG,Nick JA,Basaraba RJ

更新日期：2014-04-01 00:00:00

abstract：:This study was intentionally focused on cyclo(l-leucyl-l-prolyl) (CLP), a cyclic dipeptide with myriad pharmaceutical significance, to explore its antivirulence efficacy against the predominant foodborne pathogen,Listeria monocytogenes(LM). Minimum inhibitory concentration (MIC) of CLP against LM ATCC 19111 was found ...

journal_title：Pathogens and disease

authors： Gowrishankar S,Sivaranjani M,Kamaladevi A,Ravi AV,Balamurugan K,Karutha Pandian S

更新日期：2016-06-01 00:00:00

abstract：:Group A Streptococcus (GAS) is a globally important human pathogen that causes a broad spectrum of disease ranging from mild superficial infections to severe invasive diseases with high morbidity and mortality. Currently, there is no vaccine available for human use. GAS produces a vast array of virulence factors inclu...

journal_title：Pathogens and disease

authors： Raynes JM,Young PG,Proft T,Williamson DA,Baker EN,Moreland NJ

更新日期：2018-03-01 00:00:00

abstract：:The impact of Pseudomonas aeruginosa biofilm infections in chronic wounds and clinical implication for healing is receiving increased attention. However, the pathophysiology of host/pathogen interplay is not fully understood. By further revealing the mechanisms, necessary new treatment strategies may be identified. Si...

journal_title：Pathogens and disease

authors： Trøstrup H,Lerche CJ,Christophersen LJ,Thomsen K,Jensen PØ,Hougen HP,Høiby N,Moser C

更新日期：2017-09-29 00:00:00

abstract：:Among HIV-1 reverse transcriptase (RT)-associated functions, DNA polymerase and Ribonuclease H (RNase H) are both essential for HIV replication and excellent targets for drug development. While all RT inhibitors approved for therapy target the DNA polymerase activity, there is the pressing need for new RT inhibitors p...

journal_title：Pathogens and disease

authors： Esposito F,Sanna C,Del Vecchio C,Cannas V,Venditti A,Corona A,Bianco A,Serrilli AM,Guarcini L,Parolin C,Ballero M,Tramontano E

更新日期：2013-08-01 00:00:00

abstract：:Epstein-Barr virus proteins were examined for amino acid sequence matching to human proteins at the decapeptide level. We report that numerous EBV peptides of different length (from 10- to 13-mer) are present in 28 human proteins. The viral vs. human peptide overlap mainly involves the glycine-rich region allocated in...

journal_title：Pathogens and disease

authors： Capone G,Calabrò M,Lucchese G,Fasano C,Girardi B,Polimeno L,Kanduc D

更新日期：2013-12-01 00:00:00

abstract：:Inhalation of the fungus Cryptococcus neoformans (C. neoformans) results in pulmonary cryptococcosis associated with IL-33-dependent type 2 immunity. Lung epithelium represents the initial contact site of infection. The role of IL-33 in type 2 immunity has been analyzed, but the source of this cytokine and its effect ...

journal_title：Pathogens and disease

authors： Heyen L,Müller U,Siegemund S,Schulze B,Protschka M,Alber G,Piehler D

更新日期：2016-10-01 00:00:00

abstract：:Chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory diseases such as asthma and atherosclerosis, and its detection in human carotid and coronary atheroma suggests some support for its involvement in atherogenesis. The main objective of our study was to evaluate the association between C...

journal_title：Pathogens and disease

authors： El Yazouli L,Criscuolo A,Hejaji H,Bouazza M,Elmdaghri N,Aroussi Alami A,Amraoui A,Dakka N,Radouani F

更新日期：2017-06-01 00:00:00