Abstract：
:The role of adjuvant hormonal therapy and optimized regimens for high-risk localized prostate cancer after radical prostatectomy remains controversial. Herein, the clinical trial CU1005 prospectively evaluated two regimens of maximum androgen blockage or bicalutamide 150 mg daily as immediate adjuvant therapy for high-risk localized prostate cancer. Overall, 209 consecutive patients were recruited in this study, 107 of whom received 9 months of adjuvant maximum androgen blockage, whereas 102 received 9 months of adjuvant bicalutamide 150 mg. The median postoperative follow-up time was 27.0 months. The primary endpoint was biochemical recurrence. Of the 209 patients, 59 patients developed biochemical recurrence. There was no difference between the two groups with respect to clinical characteristics, including age, pretreatment prostate-specific antigen, Gleason score, surgical margin status, or pathological stages. The maximum androgen blockage group experienced longer biochemical recurrence-free survival (P = 0.004) compared with the bicalutamide 150 mg group. Side-effects in the two groups were similar and could be moderately tolerated in all patients. In conclusion, immediate, 9-month maximum androgen blockage should be considered as an alternative to bicalutamide 150 mg as adjuvant treatment for high-risk localized prostate cancer patients after radical prostatectomy.
journal_name
Asian J Androljournal_title
Asian journal of andrologyauthors
Chang K,Qin XJ,Zhang HL,Dai B,Zhu Y,Shi GH,Shen YJ,Zhu YY,Ye DWdoi
10.4103/1008-682X.160884subject
Has Abstractpub_date
2016-05-01 00:00:00pages
452-5issue
3eissn
1008-682Xissn
1745-7262pii
160884journal_volume
18pub_type
杂志文章,随机对照试验abstract：AIM:To test the hypothesis that season affects the semen quality of swamp buffalo (Bubalus bubalis) bulls used for artificial insemination (AI) under tropical conditions in Thailand, as it does in Bos taurus and Bos indicus. METHODS:Clinical and andrological examinations, and monitoring of semen production and quality...
journal_title：Asian journal of andrology
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journal_title：Asian journal of andrology
pub_type： 杂志文章,评审
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abstract：AIM:To evaluate the effect of a protein synthesis inhibitor cycloheximide on arresting activity in spermatogenesis and sperm count in male rats. METHODS:The study used seminiferous tubule (ST) segments from adult rats cultured in vitro with or without cycloheximide to condition culture media, which have been concentra...
journal_title：Asian journal of andrology
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journal_title：Asian journal of andrology
pub_type： 杂志文章,评审
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journal_title：Asian journal of andrology
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journal_title：Asian journal of andrology
pub_type： 杂志文章
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journal_title：Asian journal of andrology
pub_type： 杂志文章
doi：10.1038/aja.2009.63
更新日期：2010-03-01 00:00:00
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journal_title：Asian journal of andrology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Asian journal of andrology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：Asian journal of andrology
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Asian journal of andrology
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更新日期：2010-03-01 00:00:00
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journal_title：Asian journal of andrology
pub_type： 杂志文章
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journal_title：Asian journal of andrology
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pub_type： 杂志文章,多中心研究
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journal_title：Asian journal of andrology
pub_type： 杂志文章,多中心研究
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journal_title：Asian journal of andrology
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journal_title：Asian journal of andrology
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journal_title：Asian journal of andrology
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journal_title：Asian journal of andrology
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journal_title：Asian journal of andrology
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更新日期：2008-05-01 00:00:00
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journal_title：Asian journal of andrology
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
