Class 3 semaphorins negatively regulate dermal lymphatic network formation.

abstract：:Altered gravity load induced by spaceflight (microgravity) and centrifugation (hypergravity) is associated with changes in circadian, metabolic, and reproductive systems. Exposure to 2-g hypergravity (HG) during pregnancy and lactation decreased rate of mammary metabolic activity and increased pup mortality. We hypoth...

journal_title：Biology open

authors： Casey T,Zakrzewska EI,Maple RL,Lintault L,Wade CE,Baer LA,Ronca AE,Plaut K

更新日期：2012-06-15 00:00:00

abstract：:Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1. Here, we made a series of UBR5 HECT domain truncation variants and, through pull-down assay, showed that the N-terminal lobe of the UBR5 ...

journal_title：Biology open

authors： Shen Q,Qiu Z,Wu W,Zheng J,Jia Z

更新日期：2018-12-14 00:00:00

abstract：:Issus coleoptratus is a small plant hopper which mainly feeds on the phloem sap from ivy. Although all parts of ivy are poisonous as the plant contains saponins, especially hederasaponins, I. coleoptratus can cope with the poison. In contrast to other animals like the stick insect Carausius morosus which accumulates s...

journal_title：Biology open

authors： Himmelsbach M,Weth A,Böhme C,Schwarz M,Bräunig P,Baumgartner W

更新日期：2016-02-10 00:00:00

abstract：:Swimming at an optimal speed is critical for breath-hold divers seeking to maximize the time they can spend foraging underwater. Theoretical studies have predicted that the optimal swim speed for an animal while transiting to and from depth is independent of buoyancy, but is dependent on drag and metabolic rate. Howev...

journal_title：Biology open

authors： Suzuki I,Sato K,Fahlman A,Naito Y,Miyazaki N,Trites AW

更新日期：2014-04-25 00:00:00

abstract：:The destruction of pancreatic β cells leads to reduced insulin secretion and eventually causes diabetes. Various types of cellular stress are thought to be involved in destruction and/or malfunction of these cells. We show that endoplasmic reticulum (ER) stress accumulation in insulin-producing cells (IPCs) generated ...

journal_title：Biology open

authors： Katsube H,Hinami Y,Yamazoe T,Inoue YH

更新日期：2019-12-20 00:00:00

abstract：:Some organisms can survive extreme desiccation caused by hypertonic osmotic pressure by entering a state of suspended animation known as osmobiosis. The free-living mycophagous nematode Aphelenchoides besseyi can be induced to enter osmobiosis by soaking in osmolytes. It is assumed that sugars (in particular trehalose...

journal_title：Biology open

authors： Chen Q,Li D,Wang F,Zhang R,Ling Y

更新日期：2017-05-15 00:00:00

abstract：:The dissemination of information is a basic element of group cohesion. In honey bees (Apis mellifera Linnaeus 1758), like in other social insects, the principal method for colony-wide information exchange is communication via pheromones. This medium of communication allows multiple individuals to conduct tasks critica...

journal_title：Biology open

authors： Avalos A,Pérez E,Vallejo L,Pérez ME,Abramson CI,Giray T

更新日期：2017-01-15 00:00:00

abstract：:The success of antiretroviral therapy (ART) has improved the survival of HIV-infected patients significantly. However, significant numbers of patients on ART whose HIV disease is well controlled show peripheral sensory neuropathy (PSN), suggesting that ART may cause PSN. Although the nucleoside reverse transcriptase i...

journal_title：Biology open

authors： Bush KM,Barber KR,Martinez JA,Tang SJ,Wairkar YP

更新日期：2021-01-27 00:00:00

abstract：:Flight is a complicated task at the centimetre scale particularly due to unsteady air fluctuations which are ubiquitous in outdoor flight environments. Flying organisms deal with these difficulties using active and passive control mechanisms to steer their body motion. Body attitudes of flapping organisms are linked w...

journal_title：Biology open

authors： Jakobi T,Kolomenskiy D,Ikeda T,Watkins S,Fisher A,Liu H,Ravi S

更新日期：2018-10-08 00:00:00

abstract：:Successful predator evasion is essential to the fitness of many animals. Variation in escape behaviour may be adaptive as it reduces predictability, enhancing escape success. High escape velocities and accelerations also increase escape success, but biomechanical factors likely constrain the behavioural range over whi...

journal_title：Biology open

authors： Hitchcock AC,Chen T,Connolly E,Darakananda K,Jeong J,Quist A,Robbins A,Ellerby DJ

更新日期：2015-04-24 00:00:00

abstract：:The endosymbiosis between dinoflagellate algae of the genus Symbiodinium and stony corals provides the foundation of coral reef ecosystems. Coral bleaching, the expulsion of endosymbionts from the coral host tissue as a consequence of heat or light stress, poses a threat to reef ecosystem functioning on a global scale...

journal_title：Biology open

authors： Gegner HM,Ziegler M,Rädecker N,Buitrago-López C,Aranda M,Voolstra CR

更新日期：2017-12-15 00:00:00

abstract：:Aggression is a fundamental part of animal social behaviour. In avian species, little is known about its neural representation. In particular, neural activity following offensive aggression has not been studied in detail. Here, we investigated the patterns of brain activation using immediate-early gene (IEG) expressio...

journal_title：Biology open

authors： Voigt C,Hirschenhauser K,Leitner S

更新日期：2018-12-10 00:00:00

abstract：:Protein phosphorylation and dephosphorylation is a key mechanism for the spatial and temporal regulation of many essential developmental processes and is especially prominent during mitosis. The multi-subunit protein phosphatase 2A (PP2A) enzyme plays an important, yet poorly characterized role in dephosphorylating pr...

journal_title：Biology open

authors： Lange KI,Heinrichs J,Cheung K,Srayko M

更新日期：2013-01-15 00:00:00

abstract：:Wnt/β-catenin signaling is involved in patterning of bone primordia, but also plays an important role in the differentiation of chondrocytes and osteoblasts. During these processes the level of β-catenin must be tightly regulated. Excess β-catenin leads to conditions with increased bone mass, whereas loss of β-catenin...

journal_title：Biology open

authors： Pflug T,Huynh-Do U,Rudloff S

更新日期：2017-05-15 00:00:00

abstract：:Vertebrate muscle development occurs through sequential differentiation of cells residing in somitic mesoderm - a process that is largely governed by transcriptional regulators. Our recent spatiotemporal microarray study in zebrafish has identified functionally uncharacterized transcriptional regulators that are expre...

journal_title：Biology open

authors： Devakanmalai GS,Zumrut HE,Ozbudak EM

更新日期：2013-04-11 00:00:00

abstract：:The cullin-RING family of ubiquitin ligases regulates diverse cellular functions, such as cell cycle control, via ubiquitylation of specific substrates. CUL3 targets its substrates through BTB proteins. Here we show that depletion of CUL3 and the BTB protein KLHL18 causes a delay in mitotic entry. Centrosomal activati...

journal_title：Biology open

authors： Moghe S,Jiang F,Miura Y,Cerny RL,Tsai MY,Furukawa M

更新日期：2012-02-15 00:00:00

abstract：:Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires removal of topoisomerase II. To analyse removal of topoisomerase II f...

journal_title：Biology open

authors： Lee KC,Padget K,Curtis H,Cowell IG,Moiani D,Sondka Z,Morris NJ,Jackson GH,Cockell SJ,Tainer JA,Austin CA

更新日期：2012-09-15 00:00:00

abstract：:Hatchling sea turtles emerge from nests, crawl down the beach and enter the sea where they typically enter a stereotypical hyperactive swimming frenzy. During this swim the front flippers are moved up and down in a flapping motion and are the primary source of thrust production. I used high-speed video linked with sim...

journal_title：Biology open

authors： Booth DT

更新日期：2014-09-04 00:00:00

abstract：:Ammonia tepida is a common and abundant benthic foraminifer in intertidal mudflats. Benthic foraminifera are primary consumers and detritivores and act as key players in sediment nutrient fluxes. In this study, laboratory feeding experiments using isotope-labeled phytodetritus were carried out with A. tepida collected...

journal_title：Biology open

authors： Wukovits J,Bukenberger P,Enge AJ,Gerg M,Wanek W,Watzka M,Heinz P

更新日期：2018-04-13 00:00:00

abstract：:Immunological responses of hibernating mammals are suppressed at low body temperatures, a possible explanation for the devastating effect of the white-nose syndrome on hibernating North American bats. However, European bats seem to cope well with the fungal causative agent of the disease. To better understand the immu...

journal_title：Biology open

authors： Fritze M,Costantini D,Fickel J,Wehner D,Czirják GÁ,Voigt CC

更新日期：2019-11-01 00:00:00

abstract：:The mammalian visual range is approximately 400-700 nm, although recent evidence suggests varying ultraviolet (UV) extensions in diverse terrestrial species. UV sensitivity may have advantages in the dim, blue light shifted environment experienced by submerged marine mammals. It may also be advantageous when seals are...

journal_title：Biology open

authors： Hogg C,Neveu M,Folkow L,Stokkan KA,Hoh Kam J,Douglas RH,Jeffery G

更新日期：2015-05-11 00:00:00

abstract：:Cardiotoxicity induced by anti-cancer therapeutics is a severe, and potentially fatal, adverse reaction of the heart in response to certain drugs. Current in vitro approaches to assess cardiotoxicity have focused on analysing cardiomyocytes. More recently it has become apparent that non-cardiomyocyte cells of the hear...

journal_title：Biology open

authors： Wilkinson EL,Sidaway JE,Cross MJ

更新日期：2016-10-15 00:00:00

abstract：:For robot-assisted rehabilitation and assessment of patients with motor dysfunction, the parametric generation of their normal gait as the input for the robot is essential to match with the features of the patient to a greater extent. In addition, the gait needs to be in three-dimensional space, which meets the physio...

journal_title：Biology open

authors： Shi D,Zhang W,Ding X,Sun L

更新日期：2020-03-05 00:00:00

abstract：:Photoreceptor cells (PRCs) mature from simple epithelial cells, a process characterised by growth and compartmentalisation of the apical membrane into an inner and an outer segment. So far, a PRC subtype-specific description of morphological and cellular changes in the developing zebrafish retina is missing. Here, we ...

journal_title：Biology open

authors： Crespo C,Knust E

更新日期：2018-10-31 00:00:00

abstract：:The aim of this study was to elucidate the role of the zipper-like structure (ZLS), a podosome-related structure that transiently appears at the cell contact zone, in osteoclast fusion. Live-cell imaging of osteoclasts derived from RAW264.7 cells transfected with EGFP-actin revealed consistent symmetrical retrograde a...

journal_title：Biology open

authors： Takito J,Otsuka H,Inoue S,Kawashima T,Nakamura M

更新日期：2017-07-15 00:00:00

abstract：:The five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB-family tumor suppressor proteins and E2F-DP transcription factors to form DREAM complexes that repress genes that regulate cell cycle progression and cell fate. The MuvB core complex also interacts with Myb family...

journal_title：Biology open

authors： Vorster PJ,Goetsch P,Wijeratne TU,Guiley KZ,Andrejka L,Tripathi S,Larson BJ,Rubin SM,Strome S,Lipsick JS

更新日期：2020-05-07 00:00:00

abstract：:Caenorhabditis elegans seam cells divide in the stem-like mode throughout larval development, with the ability to both self-renew and produce daughters that differentiate. Seam cells typically divide asymmetrically, giving rise to an anterior daughter that fuses with the hypodermis and a posterior daughter that prolif...

journal_title：Biology open

authors： Hughes S,Brabin C,Appleford PJ,Woollard A

更新日期：2013-06-06 00:00:00

abstract：:The Gata4/5/6 sub-family of zinc finger transcription factors regulate many aspects of cardiogenesis. However, critical roles in extra-embryonic endoderm also challenge comprehensive analysis during early mouse cardiogenesis, while zebrafish models have previously relied on knockdown assays. We generated targeted dele...

journal_title：Biology open

authors： Sam J,Mercer EJ,Torregroza I,Banks KM,Evans T

更新日期：2020-06-24 00:00:00

abstract：:The microtubule cytoskeleton plays important roles in cell polarity, motility and division. Microtubules inherently undergo dynamic instability, stochastically switching between phases of growth and shrinkage. In cells, some microtubule-associated proteins (MAPs) and molecular motors can further modulate microtubule d...

journal_title：Biology open

authors： Carlier-Grynkorn F,Ji L,Fraisier V,Lombard B,Dingli F,Loew D,Paoletti A,Ronot X,Tran PT

更新日期：2014-06-13 00:00:00

abstract：:Mitochondrial function is tied to the nucleus, in that hundreds of proteins encoded by nuclear genes must be imported into mitochondria. While post-translational import is fairly well understood, emerging evidence supports that mitochondrial site-specific import, or co-translational import, also occurs. However, the m...

journal_title：Biology open

authors： Sen A,Cox RT

更新日期：2016-02-01 00:00:00