Abstract:
:Identifying segments in the genome of different individuals that are identical-by-descent (IBD) is a fundamental element of genetics. IBD data is used for numerous applications including demographic inference, heritability estimation, and mapping disease loci. Simultaneous detection of IBD over multiple haplotypes has proven to be computationally difficult. To overcome this, many state of the art methods estimate the probability of IBD between each pair of haplotypes separately. While computationally efficient, these methods fail to leverage the clique structure of IBD resulting in less powerful IBD identification, especially for small IBD segments.
journal_name
BMC Bioinformaticsjournal_title
BMC bioinformaticsauthors
Park DS,Baran Y,Hormozdiari F,Eng C,Torgerson DG,Burchard EG,Zaitlen Ndoi
10.1186/1471-2105-16-S5-S9subject
Has Abstractpub_date
2015-01-01 00:00:00pages
S9issn
1471-2105pii
1471-2105-16-S5-S9journal_volume
16 Suppl 5pub_type
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