Abstract:
AIM OF THE STUDY:The analysis of acute and late toxicity of concurrent chemoradiotherapy (CCRT) for locally advanced cervical cancer (LACC) based on review of 120 patients treated in Centre of Oncology in Krakow between 2001 and 2007. MATERIALS AND METHODS:Medium age of the patients was 52 years (43-66). Overall, 12 patients (10.0%) were in Stage IB2, 54 (45.0%) in Stage II, 43 (35.8%) in Stage III, and 11 (9.2%) in Stage IVA. Squamous cell carcinoma was present in 114 (95.0%) patients. Well-differentiated (grade 1) tumour was found in 39 (32.5%) patients, moderately differentiated (grade 2) in 41 (34.2%), and poorly differentiated (grade 3) in 40 (33.3%). Karnofsky performance status score was 70 in 72 (60.0%) patients, and 80-90 in 48 (40%). External radiation therapy was delivered with high-energy six to 15 MV photon beams using four-field brick technique. The total dose of 50 Gy was given in 25 fractions within five weeks using standard fractionation. Concurrently with external radiotherapy, six cycles of chemotherapy were administered to all the patients as an intravenous infusion of once-weekly cisplatin 40 mg/m2. On completion of external beam radiotherapy, low-dose rate brachytherapy with tandem and two colpostats was performed to deliver the dose of 40 Gy to point A in two 20 Gy insertions at weekly intervals. RESULTS:Of the 120 patients in the investigated group, 78 (65%) were disease-free for five years. Symptoms of acute treatment-related toxicity grade 3 or 4 (WHO) occurred in 21.6% of patients including leucopoenia in 7.5%. anaemia in 5.0%, nausea and vomiting in 3.3%, diarrhea in 5.0%, and urinary tract infection in 0.8%. Full planned treatment (teleradiotherapy + chemotherapy + brachytherapy) completed 78.3% of the group; full planned radiotherapy without full chemotherapy completed 20% of the patients. Late treatment complications of grade 3 or 4 were observed in two (1.6%) patients (narrowing of large intestine requiring surgery and recto-vaginal fistula). CONCLUSIONS:In patients with LACC treated with CCRT, the most frequent acute toxic effects include: haematological disorders (leucopoenia, anaemia), gastrointestinal disorders (nausea and vomiting, diarrhea), vulvo-vaginal disorders, and urinary tract infection. The most frequent late toxic effects included: rectal bleeding, bowel complications requiring surgery, stenosis or recto-vaginal fistula, and haematuria.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Jakubowicz J,Blecharz P,Skotnicki P,Reinfuss M,Walasek T,Luczynska Esubject
Has Abstractpub_date
2014-01-01 00:00:00pages
393-9issue
4eissn
0392-2936issn
2709-0086journal_volume
35pub_type
杂志文章abstract::Computerized tomography has been introduced in studies concerning neoplastic pathology of the pelvis. In this study, we have attempted to define a series of radiological signs, resulting from CT tests of pelvis or abdomen in patients with gynaecological tumors, each of which corresponds to a particular anatomopatholog...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:To determine the safety of omitting routine interval laboratory assessments, dietary restrictions, and isolation precautions between cycles of chemotherapy for gynecologic malignancies. METHODS:Data were retrospectively obtained from the records of women receiving chemotherapy for gynecologic cancer from July ...
journal_title:European journal of gynaecological oncology
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abstract::The authors report a case of cardiotoxicity secondary to 5-FU, the 67th in literature in a 46-year-old woman subjected to adjuvant therapy with a CMF protocol after surgical treatment for carcinoma of the breast, and presenting onset of clinical symptoms 16 hours after administration of the first dose. Analysis of pre...
journal_title:European journal of gynaecological oncology
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doi:
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To evaluate sensitivity and specificity of pre-operative and frozen section pathologic evaluation (FSA) in predicting high-risk (HR) histology endometrial cancer. MATERIALS AND METHODS:A retrospective analysis was performed on all patients diagnosed with endometrial cancer at a single institution. Medical reco...
journal_title:European journal of gynaecological oncology
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abstract::Ectopic breast tissue occurs when the mammary ridge fails to resolve during embryonic development. Ectopic breasts, either supernumerary or aberrant, have an incidence of 6%. Ectopic breast tissue is however hardly mentioned in the literature. Also benign and malignant alterations in these "breasts" are under-reported...
journal_title:European journal of gynaecological oncology
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更新日期:2006-01-01 00:00:00
abstract::We describe a case of right mammary homolateral recurrence with controlateral axillary invasion. The absence of occult involvement of the left breast was confirmed by MRI. A subsequent thoraco-abdomino-pelvic scan and bone scintigraphy did not reveal any metastases. Lymphoscintigraphy of the right breast, after periar...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Ovarian tumors during the first two decades of life represent the most frequent tumors of the female genital tract at this age. Clinical and therapeutical particularities differentiate them from the same tumors of older women. During the period 1993-1997, 57 ovarian tumors were diagnosed and managed in the Divisions o...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To show the importance of complete surgical pathologic staging of clinical Stage I endometrial adenocarcinoma. METHODS:A total of 106 consecutive cases of clinical Stage I endometrial adenocarcinomas in two different centers were studied. RESULTS:We found an isolated paraaortic invasion in one patient without...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,多中心研究
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更新日期:2003-01-01 00:00:00
abstract::Poland is a European country of medium female breast cancer risk but a steady, mean incidence growth of 3.5% per year makes this cancer the most frequent malignancy and a leading cause of cancer-related deaths among the women of the 1980s. Our analysis is based on data collected by the Warsaw Cancer Registry in the ye...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Uterine smooth muscle tumors are frequently classified as benign and malignant. However, an assortment of mitotic counts and nuclear atypia can be indecisive between uncertain malignant potential, and malignant uterine smooth muscle tumors. We applied three immunohistochemical parameters to distinguish between cases o...
journal_title:European journal of gynaecological oncology
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abstract::The Authors describe their experience with a combination therapy with carmustine (BCNU), cyclophosphamide (CTX) plus adriamycin (ADM) in the treatment of advanced ovarian cancer. The complete remission was obtained in 33.3% of subjects, the partial remission in 37.5%. Almost all patients suffered nausea, vomiting and ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To analyse the initial experience of pelvic exenteration for gynaecological malignancies in a tertiary referral center. MATERIALS AND METHODS:Between 2011 and 2013, 15 patients underwent a pelvic exenteration for gynaecological malignancies. RESULTS:Out of the 15 exenterations, six were total, four anterior...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Carcinosarcoma is a rare, malignant tumor of the breast, consisting of intraductal or infiltrating carcinoma contiguous or subtly merged with a highly cellular, mitotically active pleomorphic spindle cell stroma (sarcoma). It is a form of the metaplastic mammary carcinomas and it is probably derived of myoepithelial c...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Synchronous endometrioid carcinoma of the uterine corpus and ovary is an uncommon but well recognized event. Diagnosis as either a separate independent primary or as a metastatic tumor requires careful consideration of a number of gross and histological features. These features illustrate the criteria helpful in disti...
journal_title:European journal of gynaecological oncology
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doi:
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:
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doi:
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
pub_type: 临床试验,杂志文章
doi:
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journal_title:European journal of gynaecological oncology
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doi:
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:1982-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:2014-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::A case of microcarcinoma of the vulva (depth of invasion less than 5 mm) with an unexpected natural history is reported. The 338 cases, up today, reported in literature are reviewed and therapeutical protocols discussed. ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:2008-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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doi:
更新日期:1981-01-01 00:00:00
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journal_title:European journal of gynaecological oncology
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journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
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