Abstract:
BACKGROUND:The high prevalence of tobacco use in some developing nations, including Bangladesh, poses several public health challenges for these populations. Smoking behaviour is determined by genetic and environmental factors; however, the genetic determinants of smoking behaviour have not been previously examined in a Bangladeshi or South Asian population. We performed a genome-wide association study (GWAS) of tobacco smoking behaviour among a population-based sample of 5354 (2035 ever smokers and 3319 never smokers) men and women in Bangladesh. METHODS:Genome-wide association analyses were conducted for smoking initiation (ever vs never smokers), smoking quantity (cigarettes per day), age of smoking initiation, and smoking cessation (former vs current smokers). Sex-stratified associations were performed for smoking initiation. RESULTS:We observed associations for smoking initiation in the SLC39A11 region at 17q21.31 (rs2567519, p=1.33×10⁻⁷) among men and in the SLCO3A1 region at 15q26 (rs12912184, p=9.32×10⁻⁸) among women. CONCLUSIONS:These findings suggest possible underlying mechanisms related to solute carrier transporter genes, which transport neurotransmitters, nutrients, heavy metals and other substrates into cells, for smoking initiation in a South Asian population in a sex-specific pattern. Genetic markers could have potential translational implications for the prevention or treatment of tobacco use and addiction in South Asian populations and warrant further exploration.
journal_name
J Med Genetjournal_title
Journal of medical geneticsauthors
Argos M,Tong L,Pierce BL,Rakibuz-Zaman M,Ahmed A,Islam T,Rahman M,Paul-Brutus R,Rahaman R,Roy S,Jasmine F,Kibriya MG,Ahsan Hdoi
10.1136/jmedgenet-2013-102151subject
Has Abstractpub_date
2014-05-01 00:00:00pages
327-33issue
5eissn
0022-2593issn
1468-6244pii
jmedgenet-2013-102151journal_volume
51pub_type
杂志文章abstract::We describe a female infant with mental retardation and some of the phenotypic features of Williams-Beuren syndrome. Chromosome analysis showed t(X;21)(q28;q11). Diagnosis, inactivation of the X chromosome, and possible involvement of the translocation breakpoints in the pathogenesis of this syndrome are discussed. ...
journal_title:Journal of medical genetics
pub_type: 杂志文章
doi:10.1136/jmg.29.10.747
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abstract::An 18 month old girl with dysmorphic features, severe developmental delay, multiple strawberry naevi, and capillary naevi is described. No previous report of a similar association of features has been identified. ...
journal_title:Journal of medical genetics
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doi:10.1136/jmg.30.10.883
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doi:10.1136/jmedgenet-2013-101978
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doi:10.1136/jmg.35.3.238
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abstract::A child with the Tel Hashomer camptodactyly syndrome is reported. Although muscle weakness and hypoplasia are reported features of this syndrome, further investigation of muscle function has not previously been carried out. We report a raised creatine kinase and an abnormal electromyogram and muscle biopsy in this syn...
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doi:10.1136/jmg.23.3.268
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journal_title:Journal of medical genetics
pub_type: 杂志文章,评审
doi:10.1136/jmg.22.6.422
更新日期:1985-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of medical genetics
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1136/jmedgenet-2019-106344
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pub_type: 杂志文章,评审
doi:10.1136/jmedgenet-2014-102438
更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of medical genetics
pub_type: 杂志文章
doi:10.1136/jmg.12.3.289
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is an X-linked motor neuron disorder caused by an expanded CAG repeat in the gene coding for the androgen receptor (AR). The range and significance of reduced penetrance alleles in SBMA has not been fully determined to date. We prese...
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doi:10.1136/jmedgenet-2020-106963
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journal_title:Journal of medical genetics
pub_type: 杂志文章
doi:10.1136/jmg.14.4.276
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journal_title:Journal of medical genetics
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journal_title:Journal of medical genetics
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doi:10.1136/jmg.2008.062729
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journal_title:Journal of medical genetics
pub_type: 杂志文章
doi:10.1136/jmg.25.5.322
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pub_type: 杂志文章
doi:10.1136/jmg.29.2.109
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journal_title:Journal of medical genetics
pub_type: 杂志文章
doi:10.1136/jmg.2010.079343
更新日期:2010-11-01 00:00:00