FGF-2 angiogenesis in bone regeneration within critical-sized bone defects in rat calvaria.

Abstract:

OBJECTIVE:This study examined the effect of basic fibroblast growth factor (FGF)-2 with an absorbable collagen sponge on angiogenesis and bone regeneration in rat calvarial critical-sized bone defects using microcomputed tomography. METHODS:Forty 7-week-old male Fischer rats were used. The symmetrical critical-sized calvarial bone defects (5 mm diameter) were created. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each bone defect. RESULTS:Blood vessel and bone volumes were significantly higher in the 0.3% FGF-2 group compared with the control and 0.1% FGF-2 groups on day 28. Significantly more osteoblast- and osteoclast-like cells were seen in the 0.3% FGF-2 group. CONCLUSIONS:Thus, FGF-2 increased blood vessel and bone formation in rat calvarial critical-sized bone defects.

journal_name

Implant Dent

journal_title

Implant dentistry

authors

Kigami R,Sato S,Tsuchiya N,Yoshimakai T,Arai Y,Ito K

doi

10.1097/ID.0b013e31829d19f0

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

422-7

issue

4

eissn

1056-6163

issn

1538-2982

journal_volume

22

pub_type

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