Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants.

abstract：:Bone morphogenetic protein 2 (BMP2) is a growth factor that is involved in the development and progression of various types of cancer. However, the epigenetic regulation of the expression of BMP2 and the association between BMP2 expression and drug resistance in breast cancer remains to be elucidated. The present stud...

journal_title：Molecular medicine reports

authors： Du M,Su XM,Zhang T,Xing YJ

更新日期：2014-08-01 00:00:00

abstract：:Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragal...

journal_title：Molecular medicine reports

authors： Lee CY,Yang CY,Lin CC,Yu MC,Sheu SJ,Kuan YH

更新日期：2018-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has been ranked the second leading cause of cancer‑associated mortality in China and the third leading cause of cancer‑associated mortality worldwide. A number of previous studies investigating SLC44A5 have revealed important biological insight and disease‑specific functions. Therefore, ...

journal_title：Molecular medicine reports

authors： Peng GZ,Ye QF,Wang R,Li MX,Yang ZX

更新日期：2016-06-01 00:00:00

abstract：:Radix Dipsaci total saponins (RTS) are primary active components of Radix Dipsaci, which is administered orally for the treatment of osteoporosis according to Chinese Medicine. RTS have also been shown to reduce the risk of bone fractures in rats. However, the detailed molecular mechanisms underlying their action rema...

journal_title：Molecular medicine reports

authors： Niu YB,Kong XH,Li YH,Fan L,Pan YL,Li CR,Wu XL,Lu TL,Mei QB

更新日期：2015-06-01 00:00:00

abstract：:In the past decade, a group of cases with persisting haemocytopenia were separated from those with idiopathic cytopenia of undetermined significance due to the optimal response of these patients to immunosuppression therapy and due to the detection of autoantibodies in the bone marrow of haemopoietic cells. This condi...

journal_title：Molecular medicine reports

authors： Chen J,Liu H,Li L,Wang H,Li Y,Wang Y,Ding K,Hao S,Shao Y,Li L,Song J,Wang G,Shao Z,Fu R

更新日期：2019-11-01 00:00:00

abstract：:SC1, an immunoglobulin superfamily cell adhesion molecule, is expressed in embryonic tissues and plays an important role in development through its cell adhesive activity. SC1 is also found in a variety of tumors and its expression is associated with a poor prognosis. The expressional patterns of SC1 were examined in ...

journal_title：Molecular medicine reports

authors： Adachi K,Hagimori K,Kato H,Fukuda K,Kikuta M,Tsukamoto Y

更新日期：2008-03-01 00:00:00

abstract：:Tumor necrosis factor α-induced protein 8 (TNFAIP8) has been associated with the tumorigenicity of various types of cancer, however, the expression of TNFAIP8 and its function in gastric cancer remain to be fully elucidated. Therefore, the present study examined the expression and biological function of TNFAIP8 in gas...

journal_title：Molecular medicine reports

authors： Li Y,Jing C,Chen Y,Wang J,Zhou M,Liu X,Sun D,Mu L,Li L,Guo X

更新日期：2015-08-01 00:00:00

abstract：:The aim of the present study was to identify key genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis (JSA). The gene expression profile dataset GSE58667, including data from 15 human whole blood samples collected from 11 patients with JSA and four healthy controls, was analyzed ...

journal_title：Molecular medicine reports

authors： Wang Z,Han Y,Zhang Z,Jia C,Zhao Q,Song W,Chen T,Zhang Y,Wang X

更新日期：2018-08-01 00:00:00

abstract：:The aim of the present was to evaluate the effects of DNA methylation and histone acetylation on 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD)‑induced cleft palate in fetal mice. Pregnant mice (n=10) were randomly divided into two groups: i) TCDD group, mice were treated with 28 µg/kg TCDD on gestation day (GD) 10 by ora...

journal_title：Molecular medicine reports

authors： Yuan X,Qiu L,Pu Y,Liu C,Zhang X,Wang C,Pu W,Fu Y

更新日期：2016-08-01 00:00:00

abstract：:Following the publication of this article, the authors have realized that an error was made with the description of the first and fourth listed affiliation addresses: "North China University of Science and of Technology", should have been written as "North China University of Science and Technology". This error also a...

journal_title：Molecular medicine reports

authors： Bao Z,Hao J,Li Y,Feng F

更新日期：2020-06-01 00:00:00

abstract：:Tuberous sclerosis (TS) is caused by mutation of the tumor suppressor genes, tuberous sclerosis complex 1 (TSC1) or 2 (TSC2). The aim of the present study was to compare the frequency and types of TSC1 and TSC2 mutations in American, British, Polish and Taiwanese populations. A meta‑analysis of 380 TS patients was per...

journal_title：Molecular medicine reports

authors： Jóźwiak J,Sontowska I,Płoski R

更新日期：2013-09-01 00:00:00

abstract：:Genistein is an important chemopreventive agent against atherosclerosis and cancer. However, whether genistein is effective in the treatment of lung cancer, and its underlying mechanism, remains to be determined. The present study demonstrated that genistein treatment of A549 lung cancer cells decreased viability in a...

journal_title：Molecular medicine reports

authors： Zhang J,Su H,Li Q,Li J,Zhao Q

更新日期：2017-04-01 00:00:00

abstract：:Ginkgolide B is one of the components extracted from Folium Ginkgo. It is a natural antagonist of platelet‑activating factor receptor and has multiple pharmacological applications. In the present study, the effect of ginkgolide B on the proliferation of endothelial progenitor cells (EPCs) was examined, as well as its ...

journal_title：Molecular medicine reports

authors： Chang J,Xue X,Song C,Liu B,Gao L

更新日期：2017-10-01 00:00:00

abstract：:Obesity is marked by deposition of collagen I in adipose tissue. Toll like receptor (TLR)2 is involved in lipid metabolism, however the association between TLR2 and collagen I remains unclear. The present study was designed to investigate the effect of TLR2 knockout on collagen I in adipose tissue in obese mice. TLR2 ...

journal_title：Molecular medicine reports

authors： Song B,Zhang H,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) and ligamentum flavum hypertrophy (LFH) are major causes of degenerative spinal disorders. Comparative and proteomic analysis was used to identify differentially expressed proteins (DEPs) in IDD and LFH discs compared with normal discs. Subsequent gene ontology term enrichment an...

journal_title：Molecular medicine reports

authors： Liu C,Yang M,Liu L,Zhang Y,Zhu Q,Huang C,Wang H,Zhang Y,Li H,Li C,Huang B,Feng C,Zhou Y

更新日期：2020-01-01 00:00:00

abstract：:The present study aimed to investigate the expression of the Hedgehog (Hh) signaling pathway between microsatellite-unstable (MSI) and microsatellite-unstable (MSS) colorectal cancers (CRCs). A total of 61 samples of CRC tissue and corresponding blood samples were obtained from the surgical department of our hospital....

journal_title：Molecular medicine reports

authors： Hu X,Lai D,Chen W,Zi S,Li J,Du P,Wang Z,Huang S,Long C

更新日期：2011-09-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common types of cancer in the urinary system in men. Zeylenone (Zey), a naturally occurring cyclohexene oxide, has an anticancer effect. In the present study, the role and potential mechanism of Zey in PCa were examined. The proliferative, invasive and migratory capacities of D...

journal_title：Molecular medicine reports

authors： Zeng S,Zhu B,Zeng J,Wu W,Jiang C

更新日期：2018-12-01 00:00:00

abstract：:Gliomas are one of the most common and most aggressive types of central nervous system tumor. Angiogenesis is an important basis for the growth of solid tumors, including gliomas, which is regulated by microRNAs (miRNAs). However, the mechanism remains unclear. Recently, it was demonstrated that miR‑24 was upregulated...

journal_title：Molecular medicine reports

authors： Dai D,Huang W,Lu Q,Chen H,Liu J,Hong B

更新日期：2018-07-01 00:00:00

abstract：:One of the major reasons for failure after total joint arthroplasty is aseptic loosening of the implant. At articulating surfaces, defined as the interface between implant and surrounding bone cement, wear particles can be generated and released into the periprosthetic tissue, resulting in inflammation and osteolysis....

journal_title：Molecular medicine reports

authors： Jonitz-Heincke A,Lochner K,Schulze C,Pohle D,Pustlauk W,Hansmann D,Bader R

更新日期：2016-08-01 00:00:00

abstract：:Placental mesenchymal stem cells (PMSCs) have important biological properties and the potential for application in numerous clinical fields, including hematopoietic stem cell transplantation and myocardial repair. There are two types of MSCs in the placenta, amniotic mesenchymal stem cells (AMSCs) and chorion mesenchy...

journal_title：Molecular medicine reports

authors： Li F,Xu Y,Xu X,Xu B,Zhao J,Zhang X

更新日期：2014-07-01 00:00:00

abstract：:Systemic lupus erythematosus is a connective tissue disease characterized by autoimmune inflammation, which leads to specific and nonspecific immune disorders with the formation of various autoantibodies by activated B cells. B‑cell‑activating factor (BAFF) is secreted by macrophages and activated T cells, and is resp...

journal_title：Molecular medicine reports

authors： Ge F,Wang F,Yan X,Li Z,Wang X

更新日期：2017-11-01 00:00:00

abstract：:Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various act...

journal_title：Molecular medicine reports

authors： Zhu Y,Zhang H

更新日期：2015-05-01 00:00:00

abstract：:Cordyceps militaris (CM), an entomopathogenic fungus belonging to the class ascomycetes, possesses various pharmacological activities, including cytotoxic effects, on various types of human tumor cells. The present study investigated the anti‑hepatocellular carcinoma (HCC) and anti‑breast cancer effects of CM in in vi...

journal_title：Molecular medicine reports

authors： Song J,Wang Y,Teng M,Zhang S,Yin M,Lu J,Liu Y,Lee RJ,Wang D,Teng L

更新日期：2016-06-01 00:00:00

abstract：:The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 w...

journal_title：Molecular medicine reports

authors： Cao Z,Ye BD,Shen ZW,Cheng XF,Yang ZX,Liu YY,Wu RH,Geng K,Xiao YY

更新日期：2015-06-01 00:00:00

abstract：:microRNAs (miRNAs) have been reported to be involved in various human diseases. They may have uses in diagnosis and as therapeutic targets, thus the discovery of novel miRNAs has the potential to provide clinical tools or shed light on novel mechanisms. In the current study, miR‑107 was revealed to be downregulated in...

journal_title：Molecular medicine reports

authors： Ruan J,Liu X,Xiong X,Zhang C,Li J,Zheng H,Huang C,Shi Q,Weng Y

更新日期：2015-02-01 00:00:00

abstract：:Glioma is one of the most common malignant tumors affecting the central nervous system. We screened active drugs from 12 classes to provide experimental data for the study of human glioma. Serum-free suspension clone formation was used to induce the formation of glioma stem‑like cel...

journal_title：Molecular medicine reports

authors： Feng X,Zhou Q,Liu C,Tao ML

更新日期：2012-11-01 00:00:00

abstract：:The splicing factor is important in cancer development, modulation numerous tumor suppressors and oncogenes, and regulation of multiple signaling pathways. Splicing factor 2/alternative splicing factor (SF2/ASF) is a proto‑oncogene, which has been implicated in the development of hepatocellular carcinoma. However, the...

journal_title：Molecular medicine reports

authors： Zhao Y,Zhu T,Zhang X,Wang Q,Zhang J,Ji W,Ma Y

更新日期：2015-09-01 00:00:00

abstract：:Clara cell protein (CC16) is an anti-inflammatory protein, which is expressed in the airway epithelium. It is involved in the development of airway inflammatory diseases, including chronic obstructive pulmonary disease and asthma. However, the exact molecular mechanism underlying its anti‑inflammatory action remains t...

journal_title：Molecular medicine reports

authors： Pang M,Bai XY,Li Y,Bai JZ,Yuan LR,Ren SA,Hu XY,Zhang XR,Yu BF,Guo R,Wang HL

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to evaluate the feasibility and safety of porcine Descemet's membrane (DM) as a carrier for the generation of tissue-engineered corneal endothelium by analyzing porcine endogenous retroviruses (PERVs) and the α-gal epitope. The morphology of porcine and human DM was observed by hematoxylin an...

journal_title：Molecular medicine reports

authors： Diao YM,Hong J

更新日期：2015-08-01 00:00:00

abstract：:Single nucleotide polymorphisms associated with lipid metabolism and energy balance are implicated in the weight loss response caused by nutritional interventions. Diet‑induced weight loss is also associated with differential global DNA methylation. DNA methylation has been proposed as a predictive biomarker for weigh...

journal_title：Molecular medicine reports

authors： Pirini F,Rodriguez-Torres S,Ayandibu BG,Orera-Clemente M,Gonzalez-de la Vega A,Lawson F,Thorpe RJ Jr,Sidransky D,Guerrero-Preston R

更新日期：2018-01-01 00:00:00