Abstract:
INTRODUCTION:Post-prostatectomy radiotherapy (PPRT) with intensity-modulated radiation therapy (IMRT) has the potential to decrease toxicity by reducing dose to surrounding structures. We assessed its impact on health-related quality of life (HRQoL). METHODS:PPRT patients were enrolled in a prospective HRQoL database. To be eligible, patients were required to be treated with IMRT and have a minimum of 15-month follow up. HRQoL was assessed at baseline, 3, 9 and 15-24 months using the Expanded Prostate Cancer Index Composite questionnaire. Higher scores reflected better HRQoL. Results were analysed as both population means and as individual scores where a moderate change was 10-20 points and a substantial change was >20 points. RESULTS:There were 64 patients eligible and 83% of the cohort received salvage radiotherapy. Prescribed dose was 64 Gy in 32 fractions for adjuvant and 66 Gy in 33 fractions for salvage IMRT. Mean function scores for urinary, bowel and sexual domains were similar at baseline and 15 months (83.5, 94.2 and 16.9 vs. 82.2, 93.1 and 14.3, respectively). Mean global physical functioning (51.0 vs. 48.1) and mental functioning (51.6 vs. 54.2) showed no difference over time. Individual patient scores by 2 years showed a >20-point deterioration in urinary (12.5%), bowel (1.6%), sexual function (9.4%), physical functioning (3.1%) and mental functioning (1.6%). CONCLUSION:This report on HRQoL following post-prostatectomy IMRT demonstrates no variation in mean scores in any domain and only 1.6% of patients reporting a greater than 20-point deterioration between baseline and 15-24 months in bowel function.
journal_name
J Med Imaging Radiat Oncoljournal_title
Journal of medical imaging and radiation oncologyauthors
van Gysen KL,Kneebone AB,Guo L,Vaux KJ,Lazzaro EM,Eade TNdoi
10.1111/j.1754-9485.2012.02464.xsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
89-96issue
1eissn
1754-9477issn
1754-9485journal_volume
57pub_type
临床试验,杂志文章abstract:INTRODUCTION:This paper outlines the key results of the Faculty of Radiation Oncology 2010 workforce survey and compares these results with earlier data. METHODS:The workforce survey was conducted in mid-2010 using a custom-designed 17-question survey. The overall response rate was 76%. RESULTS:The majority of radiat...
journal_title:Journal of medical imaging and radiation oncology
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pub_type: 临床试验,杂志文章
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