Abstract:
:Population pharmacokinetic modelling is widely used within the field of clinical pharmacology as it helps to define the sources and correlates of pharmacokinetic variability in target patient populations and their impact upon drug disposition; and population pharmacokinetic modelling provides an estimation of drug pharmacokinetic parameters. This method's defined outcome aims to understand how participants in population pharmacokinetic studies are representative of the population as opposed to the healthy volunteers or highly selected patients in traditional pharmacokinetic studies. This review focuses on the fundamentals of population pharmacokinetic modelling and how the results are evaluated and validated. This review defines the common aspects of population pharmacokinetic modelling through a discussion of the literature describing the techniques and placing them in the appropriate context. The concept of validation, as applied to population pharmacokinetic models, is explored focusing on the lack of consensus regarding both terminology and the concept of validation itself. Population pharmacokinetic modelling is a powerful approach where pharmacokinetic variability can be identified in a target patient population receiving a pharmacological agent. Given the lack of consensus on the best approaches in model building and validation, sound fundamentals are required to ensure the selected methodology is suitable for the particular data type and/or patient population. There is a need to further standardize and establish the best approaches in modelling so that any model created can be systematically evaluated and the results relied upon.
journal_name
Clin Pharmacokinetjournal_title
Clinical pharmacokineticsauthors
Sherwin CM,Kiang TK,Spigarelli MG,Ensom MHdoi
10.1007/BF03261932subject
Has Abstractpub_date
2012-09-01 00:00:00pages
573-90issue
9eissn
0312-5963issn
1179-1926journal_volume
51pub_type
杂志文章,评审abstract::Cancer chemotherapy doses are empirical in that the majority are administered at a fixed dose (mg/m2 or mg/kg). One reason for this is the intrinsic sensitivity of the tumour or host cells to one particular chemotherapy agent is unknown. Therefore, the likelihood of response or toxicity is unpredictable a priori. This...
journal_title:Clinical pharmacokinetics
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doi:10.2165/00003088-199732040-00005
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abstract::Aminoglycosides are important antibacterial agents for the treatment of serious infection. Evidence suggests that high peak plasma concentrations must be achieved early in the course of treatment if these agents are to be effective, but prolonged high concentrations may cause ototoxicity and nephrotoxicity. Peak plasm...
journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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pub_type: 杂志文章,评审
doi:10.2165/00003088-199835020-00003
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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doi:10.2165/00003088-198207050-00005
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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更新日期:2007-01-01 00:00:00
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journal_title:Clinical pharmacokinetics
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更新日期:2013-08-01 00:00:00
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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更新日期:2008-01-01 00:00:00