Efficacy of VBHOM to predict outcome following major lower limb amputation.

Abstract:

PURPOSE:This study tests an existing Vascular Biochemistry and Haematology Outcome Model (VBHOM) on independent data and presents further refinements to the model. METHODS:Data from 306 patients who underwent lower limb amputation over a 4-year period were collated. Urea, creatinine, sodium, potassium, hemoglobin, white cell count, albumin, age, gender, mode-of-admission, and short-term mortality events were extracted from the database. This study tests an existing model and trains a new model for predicting mortality using forward stepwise logistic regression. RESULTS:The existing model suggests a significant lack of fit (c-index = 0.665, P = .04). For the exception of gender and mode-of-admission, all predictor variables had significant univariate associations with short-term mortality (P < .05). The refined model included age, sodium, potassium, creatinine, and albumin and had good discriminatory power (c-index = 0.8, no evidence of lack of fit, P = .616). CONCLUSIONS:Our simplified model had good predictive ability and suggests redundancy in input variables used by the existing models.

journal_name

Vasc Endovascular Surg

authors

Patterson AJ,Degnan AJ,Walsh SR,Eltayeb M,Scout EF,Clarke JM,Wilson YG,Tang TY

doi

10.1177/1538574412445600

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

369-73

issue

5

eissn

1538-5744

issn

1938-9116

pii

1538574412445600

journal_volume

46

pub_type

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