Does vitamin B alter the efficacy of botulinum toxin?

Abstract:

:Botulinum toxin prevents acetylcholine release at motor nerve terminals. Group B vitamins (B-vit) are essential for proper nerve function. The present study addresses the question of whether B-vit accelerate recovery in rat skeletal muscle after botulinum toxin A (Btx-A) injection. Forty-four adult male Wistar albino rats were used in this experimental study. Rats were divided into three groups: group 1 rats were given Btx-A injection only, group 2 rats were given B-vit supplementation before Btx-A injection, and group 3 rats were given Btx-A and B-vit injections together. During the experiment, compound muscle action potential (CMAP) of the gastrocnemius muscle was recorded before Btx-A injection and sequentially ten times after toxin injection. The statistical significance of the CMAP amplitude change among the groups was analyzed. All groups showed similar amplitude change between consecutive measurement points. In conclusion, combining Btx-A injection with B-vit supplement does not decrease the efficacy of the toxin.

journal_name

Aesthetic Plast Surg

authors

Tatlidede S,Baslo MB,Özkaya Ö,Soydan T,Orhan EK,Yeşilada AK

doi

10.1007/s00266-012-9873-6

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

692-7

issue

3

eissn

0364-216X

issn

1432-5241

journal_volume

36

pub_type

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